Publication
Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult
| Summary: | Abstract Introduction: Gastric cancer is the fourth most common cause of cancer death, with more than 90% of the cases being adenocarcinomas. Among the diverse subtypes, mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is one of the rarest types. Gastric cancer can manifest with significant bleeding in up to 5% of patients. Case Presentation: The authors present a case of a healthy 26-year-old male who experienced two episodes of major upper gastrointestinal bleeding that were resolved with endoscopic treatment. During the second endoscopy, a 15-mm nodular subepithelial lesion was identified at the gastroesophageal junction. Endoscopic ultrasound revealed a homogeneous and hypoechoic lesion with well-defined limits in the deep mucosa. Histological examination of the biopsies showed an adenocarcinoma. The patient later underwent a distal esophagectomy and a total gastrectomy, followed by chemotherapy. Histological examination of the surgical specimen showed a mixed adenoneuroendocrine carcinoma composed of an ade nocarcinoma with tubular/glandular pattern and signet ring cells and a large cell-type neuroendocrine carcinoma. The neoplasia had infiltrated the outer muscular layers of the stomach and had disseminated to 3 regional lymph nodes, leading to its classification as stage IIb. Two years following the treatment, there is no evidence of recurrence. All genetic tests applied were negative. Discussion: A MiNEN occurs when both neuroendocrine and non-neuroendocrine components represent at least 30% of the lesion. Due to its rarity, epidemiology and standard treatment are not well established because most data published are from case reports. In this context, we present a compelling case study, highlighting the patient’s young age, the rarity of this specific cancer, and its uncommon presentation. |
|---|---|
| Main Authors: | Carvalho,Tânia |
| Other Authors: | Coutada,Andreia; Jácome,Manuel; Fernandes,Dália |
| Subject: | Gastric cancer Mixed neuroendocrine-non-neuroendocrine neoplasm Upper gastrointestinal bleeding |
| Year: | 2024 |
| Country: | Portugal |
| Document type: | report |
| Access type: | open access |
| Associated institution: | Fundação para a Ciência e Tecnologia |
| Language: | English |
| Origin: | SciELO Portugal |
| _version_ | 1868442017099415552 |
|---|---|
| author | Carvalho,Tânia |
| author2 | Coutada,Andreia Jácome,Manuel Fernandes,Dália |
| author2_role | author author author |
| author_facet | Carvalho,Tânia Coutada,Andreia Jácome,Manuel Fernandes,Dália |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Carvalho,Tânia\"},{\"Person.name\":\"Coutada,Andreia\"},{\"Person.name\":\"Jácome,Manuel\"},{\"Person.name\":\"Fernandes,Dália\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Carvalho,Tânia Coutada,Andreia Jácome,Manuel Fernandes,Dália |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Gastric cancer Mixed neuroendocrine-non-neuroendocrine neoplasm Upper gastrointestinal bleeding |
| datacite.titles.title.fl_str_mv | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult |
| dc.creator.none.fl_str_mv | Carvalho,Tânia Coutada,Andreia Jácome,Manuel Fernandes,Dália |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000600056 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | GE-Portuguese Journal of Gastroenterology v.31 n.6 2024 |
| dc.subject.none.fl_str_mv | Gastric cancer Mixed neuroendocrine-non-neuroendocrine neoplasm Upper gastrointestinal bleeding |
| dc.title.fl_str_mv | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_93fc |
| description | Abstract Introduction: Gastric cancer is the fourth most common cause of cancer death, with more than 90% of the cases being adenocarcinomas. Among the diverse subtypes, mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is one of the rarest types. Gastric cancer can manifest with significant bleeding in up to 5% of patients. Case Presentation: The authors present a case of a healthy 26-year-old male who experienced two episodes of major upper gastrointestinal bleeding that were resolved with endoscopic treatment. During the second endoscopy, a 15-mm nodular subepithelial lesion was identified at the gastroesophageal junction. Endoscopic ultrasound revealed a homogeneous and hypoechoic lesion with well-defined limits in the deep mucosa. Histological examination of the biopsies showed an adenocarcinoma. The patient later underwent a distal esophagectomy and a total gastrectomy, followed by chemotherapy. Histological examination of the surgical specimen showed a mixed adenoneuroendocrine carcinoma composed of an ade nocarcinoma with tubular/glandular pattern and signet ring cells and a large cell-type neuroendocrine carcinoma. The neoplasia had infiltrated the outer muscular layers of the stomach and had disseminated to 3 regional lymph nodes, leading to its classification as stage IIb. Two years following the treatment, there is no evidence of recurrence. All genetic tests applied were negative. Discussion: A MiNEN occurs when both neuroendocrine and non-neuroendocrine components represent at least 30% of the lesion. Due to its rarity, epidemiology and standard treatment are not well established because most data published are from case reports. In this context, we present a compelling case study, highlighting the patient’s young age, the rarity of this specific cancer, and its uncommon presentation. |
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| person_str_mv | Carvalho,Tânia Coutada,Andreia Jácome,Manuel Fernandes,Dália |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Gastrenterologia |
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| spelling | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young AdultCarvalho,TâniaCoutada,AndreiaJácome,ManuelFernandes,DáliaGastric cancerMixed neuroendocrine-non-neuroendocrine neoplasmUpper gastrointestinal bleedingopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000600056URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000600056URLHasVersion2024-12-01Abstract Introduction: Gastric cancer is the fourth most common cause of cancer death, with more than 90% of the cases being adenocarcinomas. Among the diverse subtypes, mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is one of the rarest types. Gastric cancer can manifest with significant bleeding in up to 5% of patients. Case Presentation: The authors present a case of a healthy 26-year-old male who experienced two episodes of major upper gastrointestinal bleeding that were resolved with endoscopic treatment. During the second endoscopy, a 15-mm nodular subepithelial lesion was identified at the gastroesophageal junction. Endoscopic ultrasound revealed a homogeneous and hypoechoic lesion with well-defined limits in the deep mucosa. Histological examination of the biopsies showed an adenocarcinoma. The patient later underwent a distal esophagectomy and a total gastrectomy, followed by chemotherapy. Histological examination of the surgical specimen showed a mixed adenoneuroendocrine carcinoma composed of an ade nocarcinoma with tubular/glandular pattern and signet ring cells and a large cell-type neuroendocrine carcinoma. The neoplasia had infiltrated the outer muscular layers of the stomach and had disseminated to 3 regional lymph nodes, leading to its classification as stage IIb. Two years following the treatment, there is no evidence of recurrence. All genetic tests applied were negative. Discussion: A MiNEN occurs when both neuroendocrine and non-neuroendocrine components represent at least 30% of the lesion. Due to its rarity, epidemiology and standard treatment are not well established because most data published are from case reports. In this context, we present a compelling case study, highlighting the patient’s young age, the rarity of this specific cancer, and its uncommon presentation.Sociedade Portuguesa de GastrenterologiaGE-Portuguese Journal of Gastroenterology v.31 n.6 2024text/htmlengreporthttp://purl.org/coar/resource_type/c_93fcother research product |
| spellingShingle | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult Carvalho,Tânia Gastric cancer Mixed neuroendocrine-non-neuroendocrine neoplasm Upper gastrointestinal bleeding |
| status | SINGLETON |
| subject.fl_str_mv | Gastric cancer Mixed neuroendocrine-non-neuroendocrine neoplasm Upper gastrointestinal bleeding |
| title | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult |
| title_full | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult |
| title_fullStr | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult |
| title_full_unstemmed | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult |
| title_short | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult |
| title_sort | Gastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult |
| topic | Gastric cancer Mixed neuroendocrine-non-neuroendocrine neoplasm Upper gastrointestinal bleeding |
| topic_facet | Gastric cancer Mixed neuroendocrine-non-neuroendocrine neoplasm Upper gastrointestinal bleeding |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452024000600056 |
| visible | 1 |