Publicação
Bilateral Internuclear Ophthalmoplegia: Multiple Sclerosis rather Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)?
| Resumo: | Increasing knowledge about neuro-inflammatory conditions as lead to new challenges in establishing a diagnosis. Clinical distinctive features might help. We present a 34-year-old patient with bilateral internuclear ophthalmoplegia (bINO). Investigation was compatible with demyelinating central nervous system (CNS) disease. Low-positive IgG myelin oligodendrocyte glycoprotein (MOG) antibodies were found. Rituximab was started and the patient has remained without further clinical or magnetic resonance imaging (MRI) activity. Acknowledging that bINO is a wellknown manifestation of multiple sclerosis (MS) but rarely reported among MOGAD patients its occurrence might help distinguish MS from MOGAD in an apparent overlap setting, favoring MS. |
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| Autores principais: | Marques, Ana João |
| Outros Autores: | Matas, Andreia; Gabriel, João Paulo |
| Assunto: | Esclerose Múltipla Glicoproteína Mielina- Oligodendrócito Oftalmoplegia Multiple Sclerosis Myelin-Oligodendrocyte Glycoprotein Ophthalmoplegia |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Sociedade Portuguesa de Neurologia |
| Idioma: | inglês |
| Origem: | SINAPSE |
| Resumo: | Increasing knowledge about neuro-inflammatory conditions as lead to new challenges in establishing a diagnosis. Clinical distinctive features might help. We present a 34-year-old patient with bilateral internuclear ophthalmoplegia (bINO). Investigation was compatible with demyelinating central nervous system (CNS) disease. Low-positive IgG myelin oligodendrocyte glycoprotein (MOG) antibodies were found. Rituximab was started and the patient has remained without further clinical or magnetic resonance imaging (MRI) activity. Acknowledging that bINO is a wellknown manifestation of multiple sclerosis (MS) but rarely reported among MOGAD patients its occurrence might help distinguish MS from MOGAD in an apparent overlap setting, favoring MS. |
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