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COVID-19 Associated Longitudinal Extensive Transverse Myelitis with Cerebral Spinal Fluid SARS-CoV-2 Detection

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Resumo:There have been multiple reports of COVID-19 associated neurological symp-toms, including several cases of para-infectious myelitis.We report a case of an 84-year-old male patient presenting with acute paraparesis coinciding with active mild COVID-19 pneumonia. Spinal cord magnetic resonance imaging (MRI) showed longitudinally extensive transverse myelitis (LETM) affecting the entire cervical cord to the tenth thoracic level, and cerebral spinal fluid (CSF) was positive for SARS-CoV-2. The patient was evaluated for other causes of LETM, which were convincingly excluded. He was treated with steroid pulses and plasmapheresis, with significant imaging improvement. The patient has since made a good recovery, being now able to walk unassisted. Although several instances of COVID-19 associated myelitis have been reported, positive identification of the virus in CSF is rare. The identification of viral material may support the hypothesis of direct spinal cord infection in co-occurrence with a para-infectious inflammatory reaction.
Autores principais:Gomes, Fábio
Outros Autores:Lima, Cláudia; Valente, Cristina; Vaz, João; Correia, Lurdes; Correia, Inês
Assunto:COVID-19 Myelitis, Transverse RNA, Viral/cerebrospinal fluid SARS-CoV-2 COVID-19 SARS-CoV-2 Mielite Transversa RNA, Viral/líquido cefalorraquidiano
Ano:2024
País:Portugal
Tipo de documento:artigo
Tipo de acesso:unknown
Instituição associada:Sociedade Portuguesa de Neurologia
Idioma:inglês
Origem:SINAPSE

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