Publicação
Ticlopidine – induced hepatic toxicity – three clinical case reports
| Resumo: | Ticlopidine is widely used nowadays. It hasoccasionally been responsible for importanthepatotoxicity. We present three case reports of Ticlopidine-induced cholestatic hepatitis, recognised over the last years, at our institution. All three patients were male, with regular significant ethanolintake. They all presented with serious symptomaticcholestatic jaundice. Liver biopsy was performed inall 3 patients and was consistent with toxiccholestasis, and we emphasize the presence ofgranulomas in two of them. In two patients alkalinephosphatase, gamma-glutamyl transpeptidase andcholesterol reached exceptionally high levels.Although clinically well more than eleven monthsafter drug suspension, two patients still presentedlaboratory evidence of cholestasis. One patient hadinitially important but reversible anaemia ofunestablished aetiology. After a short generalintroduction on the subject of acute hepatic drugtoxicity we compare our cases with other ticlopidine-induced cholestatic hepatitis case reports publishedin the international literature. |
|---|---|
| Autores principais: | Guimarães, Fernando |
| Outros Autores: | Regadas, Maria João; Roquete, Pedro |
| Assunto: | Ticlopidina colestase hepatite medicamentosa Ticlopidine cholestasis drug - induced hepatitis |
| Ano: | 2001 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Instituição associada: | Sociedade Portuguesa de Medicina Interna |
| Idioma: | português |
| Origem: | Revista Portuguesa de Medicina Interna |
| _version_ | 1869318934797221888 |
|---|---|
| author | Guimarães, Fernando |
| author2 | Regadas, Maria João Roquete, Pedro |
| author2_role | author author |
| author_facet | Guimarães, Fernando Regadas, Maria João Roquete, Pedro |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Guimarães, Fernando\"},{\"Person.name\":\"Regadas, Maria João\"},{\"Person.name\":\"Roquete, Pedro\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Guimarães, Fernando Regadas, Maria João Roquete, Pedro |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Ticlopidina colestase hepatite medicamentosa Ticlopidine cholestasis drug - induced hepatitis |
| datacite.titles.title.fl_str_mv | Ticlopidine – induced hepatic toxicity – three clinical case reports Hepatotoxicidade por ticlopidina - a propósito de três casos clínicos |
| dc.creator.none.fl_str_mv | Guimarães, Fernando Regadas, Maria João Roquete, Pedro |
| dc.description.none.fl_str_mv | A ticlopidina é utilizada em larga escala naactualidade. Tem sido ocasionalmente responsabilizada por importante hepatotoxicidade. Publicamosneste artigo três casos de hepatite colestática porticlopidina observados nos últimos anos na nossainstituição. Todos os doentes eram de sexomasculino, com consumo regular significativo deetanol, e tiveram grave icterícia colestáticasintomática. Em todos foi efectuada biopsia hepática,com resultado consistente com colestase tóxica,sendo de salientar em dois a presença de granulomas. Dois dos doentes atingiram valores defosfatase alcalina e gamaglutamiltransferase e decolesterol excepcionalmente elevados. Em doisdoentes, embora clinicamente bem, mais de onzemeses após a suspensão do fármaco persistiaevidência enzimática de colestase. Um doente teveinicialmente anemia acentuada, reversível, cujaetiologia não conseguimos estabelecer. Após brevealusão genérica à problemática da toxicidademedicamentosa aguda sobre o fígado, confrontámosos nossos casos com outros casos de hepatitecolestática induzida pela ticlopidina relatados naliteratura internacional. |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://revista.spmi.pt/index.php/rpmi/article/view/1908 |
| dc.language.none.fl_str_mv | por |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Medicina Interna |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | https://creativecommons.org/licenses/by-nc/4.0 |
| dc.source.none.fl_str_mv | Internal Medicine; Vol. 8 No. 3 (2001): Julho/ Setembro; 132-137 Medicina Interna; Vol. 8 N.º 3 (2001): Julho/ Setembro; 132-137 2183-9980 0872-671X |
| dc.subject.none.fl_str_mv | Ticlopidina colestase hepatite medicamentosa Ticlopidine cholestasis drug - induced hepatitis |
| dc.title.fl_str_mv | Ticlopidine – induced hepatic toxicity – three clinical case reports Hepatotoxicidade por ticlopidina - a propósito de três casos clínicos |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Ticlopidine is widely used nowadays. It hasoccasionally been responsible for importanthepatotoxicity. We present three case reports of Ticlopidine-induced cholestatic hepatitis, recognised over the last years, at our institution. All three patients were male, with regular significant ethanolintake. They all presented with serious symptomaticcholestatic jaundice. Liver biopsy was performed inall 3 patients and was consistent with toxiccholestasis, and we emphasize the presence ofgranulomas in two of them. In two patients alkalinephosphatase, gamma-glutamyl transpeptidase andcholesterol reached exceptionally high levels.Although clinically well more than eleven monthsafter drug suspension, two patients still presentedlaboratory evidence of cholestasis. One patient hadinitially important but reversible anaemia ofunestablished aetiology. After a short generalintroduction on the subject of acute hepatic drugtoxicity we compare our cases with other ticlopidine-induced cholestatic hepatitis case reports publishedin the international literature. |
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| person_str_mv | Guimarães, Fernando Regadas, Maria João Roquete, Pedro |
| publishDate | 2001 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Medicina Interna |
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| spelling | en-USTiclopidine – induced hepatic toxicity – three clinical case reportspt-PTHepatotoxicidade por ticlopidina - a propósito de três casos clínicosGuimarães, FernandoRegadas, Maria JoãoRoquete, PedroTiclopidinacolestasehepatite medicamentosaTiclopidinecholestasisdrug - induced hepatitishttp://purl.org/coar/access_right/c_abf2https://revista.spmi.pt/index.php/rpmi/article/view/1908URLhttps://revista.spmi.pt/index.php/rpmi/article/view/1908URLHasVersionhttps://revista.spmi.pt/index.php/rpmi/article/view/1908/1338URLHasVersion2001-09-28en-USTiclopidine is widely used nowadays. It hasoccasionally been responsible for importanthepatotoxicity. We present three case reports of Ticlopidine-induced cholestatic hepatitis, recognised over the last years, at our institution. All three patients were male, with regular significant ethanolintake. They all presented with serious symptomaticcholestatic jaundice. Liver biopsy was performed inall 3 patients and was consistent with toxiccholestasis, and we emphasize the presence ofgranulomas in two of them. In two patients alkalinephosphatase, gamma-glutamyl transpeptidase andcholesterol reached exceptionally high levels.Although clinically well more than eleven monthsafter drug suspension, two patients still presentedlaboratory evidence of cholestasis. One patient hadinitially important but reversible anaemia ofunestablished aetiology. After a short generalintroduction on the subject of acute hepatic drugtoxicity we compare our cases with other ticlopidine-induced cholestatic hepatitis case reports publishedin the international literature.pt-PTA ticlopidina é utilizada em larga escala naactualidade. Tem sido ocasionalmente responsabilizada por importante hepatotoxicidade. Publicamosneste artigo três casos de hepatite colestática porticlopidina observados nos últimos anos na nossainstituição. Todos os doentes eram de sexomasculino, com consumo regular significativo deetanol, e tiveram grave icterícia colestáticasintomática. Em todos foi efectuada biopsia hepática,com resultado consistente com colestase tóxica,sendo de salientar em dois a presença de granulomas. Dois dos doentes atingiram valores defosfatase alcalina e gamaglutamiltransferase e decolesterol excepcionalmente elevados. Em doisdoentes, embora clinicamente bem, mais de onzemeses após a suspensão do fármaco persistiaevidência enzimática de colestase. Um doente teveinicialmente anemia acentuada, reversível, cujaetiologia não conseguimos estabelecer. Após brevealusão genérica à problemática da toxicidademedicamentosa aguda sobre o fígado, confrontámosos nossos casos com outros casos de hepatitecolestática induzida pela ticlopidina relatados naliteratura internacional.Sociedade Portuguesa de Medicina Internaapplication/pdfen-USInternal Medicine; Vol. 8 No. 3 (2001): Julho/ Setembro; 132-137pt-PTMedicina Interna; Vol. 8 N.º 3 (2001): Julho/ Setembro; 132-1372183-99800872-671Xporjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85https://creativecommons.org/licenses/by-nc/4.0 |
| spellingShingle | Ticlopidine – induced hepatic toxicity – three clinical case reports Guimarães, Fernando Ticlopidina colestase hepatite medicamentosa Ticlopidine cholestasis drug - induced hepatitis |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | Ticlopidina colestase hepatite medicamentosa Ticlopidine cholestasis drug - induced hepatitis |
| title | Ticlopidine – induced hepatic toxicity – three clinical case reports |
| title_full | Ticlopidine – induced hepatic toxicity – three clinical case reports |
| title_fullStr | Ticlopidine – induced hepatic toxicity – three clinical case reports |
| title_full_unstemmed | Ticlopidine – induced hepatic toxicity – three clinical case reports |
| title_short | Ticlopidine – induced hepatic toxicity – three clinical case reports |
| title_sort | Ticlopidine – induced hepatic toxicity – three clinical case reports |
| topic | Ticlopidina colestase hepatite medicamentosa Ticlopidine cholestasis drug - induced hepatitis |
| topic_facet | Ticlopidina colestase hepatite medicamentosa Ticlopidine cholestasis drug - induced hepatitis |
| url | https://revista.spmi.pt/index.php/rpmi/article/view/1908 |
| visible | 1 |