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Chronic Histiocytic Intervillositis: A Rare Cause of Placenta Mediated Obstetrical Events Associated with Isolated Alkaline Phosphatase Elevation?

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Resumo:The authors report a case of a 31-year-old woman, pregnantfor the third time, with a medical history of severe placentalmediated obstetrical complications, referred for exclusion ofa pro-thrombotic state. Thrombophilia testing was negative,however isolated alkaline phosphates elevation (10 times superiorto the upper reference limit) was detected. Alkalinephosphatase elevation that does not surpass twice the upperreference limit during the third trimester of pregnancy isconsidered normal. Elevation beyond those levels requiresdifferential diagnosis with liver, bone and renal disease.Off-label anti-thrombotic therapy was offered during the entirepregnancy, which carried on. The patient gave birth toa healthy baby. Evaluation of the placenta revealed chronichistiocytic intervillositis, a rare pathology yet to be fully understood,linked to autoimmune placental phenomena andelevated alkaline phosphatase.
Autores principais:Ferreira, Melanie
Outros Autores:Fonseca, Ana Glória; Cunha, Vitória; Almeida, Maria Manuela; Santos, Antónia; Ilgenfritz, Raquel
Assunto:Complicações na Gravidez Doenças Placentárias Fosfatase Alcalina Histiócitos Vilosidades Coriónicas Alkaline Phosphatase Chorionic Villi Histiocytes Placenta Diseases Pregnancy Complications
Ano:2017
País:Portugal
Tipo de documento:artigo
Tipo de acesso:unknown
Instituição associada:Sociedade Portuguesa de Medicina Interna
Idioma:português
Origem:Revista Portuguesa de Medicina Interna

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