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The prevalence and clinicai significance of "hepatitis" G infection in different groups
| Resumo: | Background: The role of HGV /GBV-C in liver pathology, and in association with HCV or HBV infections is not completely understood. HGV infection has not yet been studied in Portugal. Aims: Study of the prevalence and clinicai significance of HGV infection in carriers of HBV or HCV, in patients with chronic hepatitis of unknown aetiology, and in those belonging to some risk groups. Patients and methods: HGV-RNA was determined in serum of 118 patients (75 M, 43 F): 18 with chronic hepatitis C (group I); 17 alcoholics with anti-HCV (group II); 36 chronic haemodialysis patients (group III), 16 of them with chronic hepatitis C (IIIA) and 20 without anti-HCV or HBsAg (IIIB); 17 renal transplant recipients with HCV infection (group IV); 18 chronic hepatitis B patients (group V); 10 with chronic hepatitis with unknown aetiology (group VI); 2 women with autoimmune hepatitis.). Eleven patients {7 of group I and 4 of group II) were drug addicts. HGV-RNA was assessed by RT-PCR, with primers of the 5'NC and NS5a regions, labelled with digoxigenine. Liver histology was assesssed and correlated with HGV infection in 56 chronic hepatitis C patients and in those belonging to groups V, VI and VII. Results: We found HGV-RNA in 20 patients: 3/18 (16.7%); 2/17 (11.8%) of group II; 5/36 (13.9%) of group III, 2/16 (12.5%) of IIIA and 3/20 (15%) of IIIB; 6/17 (35.3%) of the group IV; 4/11 drug addicts (36.4%); none of the patients with cryptogenic or autoimmune hepatitis. Liver histopathology in 9 patients HCV + HGV infections showed minimal activity in 4 and mild in 5; no fibrosis in 3, portal in 6; in 4 HBV +HGV, mild activity and no fibrosis in 1, severe activity and bridging fibrosis in 3 (also alcoholics). The 3 haemodialysed with only HGV infection had normal ALT and GGT. Conclusions: The prevalence of HGV infection was quite similar in most of the studied groups (12.5 to 22%); the exceptions were drug addicts (36.4%), renal transplant patients (35,3%) and those with chronic non-BC hepatitis (0%). Our data suggest little or no pathogenicity of HGV. However, the severity of liver disease in alcoholics with HGV and HBV infections is a remarkable finding. Future studies on the relationship between this and other hepatitis vírus are warranted. |
|---|---|
| Autores principais: | de Carvalho, Armando |
| Outros Autores: | Martinho, António; Cipriano, Maria Augusta; Breda Coimbra, Henriqueta; Porto, Armando |
| Assunto: | vírus da hepatites virais hepatite crónica «bepatitis «hepatitis viral hepatitis chronic hepatitis |
| Ano: | 1999 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Instituição associada: | Sociedade Portuguesa de Medicina Interna |
| Idioma: | português |
| Origem: | Revista Portuguesa de Medicina Interna |
| _version_ | 1869318935069851648 |
|---|---|
| author | de Carvalho, Armando |
| author2 | Martinho, António Cipriano, Maria Augusta Breda Coimbra, Henriqueta Porto, Armando |
| author2_role | author author author author |
| author_facet | de Carvalho, Armando Martinho, António Cipriano, Maria Augusta Breda Coimbra, Henriqueta Porto, Armando |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"de Carvalho, Armando\"},{\"Person.name\":\"Martinho, António\"},{\"Person.name\":\"Cipriano, Maria Augusta\"},{\"Person.name\":\"Breda Coimbra, Henriqueta\"},{\"Person.name\":\"Porto, Armando\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | de Carvalho, Armando Martinho, António Cipriano, Maria Augusta Breda Coimbra, Henriqueta Porto, Armando |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | vírus da hepatites virais hepatite crónica «bepatitis «hepatitis viral hepatitis chronic hepatitis |
| datacite.titles.title.fl_str_mv | The prevalence and clinicai significance of "hepatitis" G infection in different groups Prevalência e significado clínico da infecção pelo vírus da "hepatite" G em diversos grupos de doentes |
| dc.creator.none.fl_str_mv | de Carvalho, Armando Martinho, António Cipriano, Maria Augusta Breda Coimbra, Henriqueta Porto, Armando |
| dc.description.none.fl_str_mv | Introdução: A descoberta de outro vírus hepatotrópico (VHG/VGB-C) trouxe alguma esperança para o esclarecimento das hepatites não A-E, que dados mais recentes têm desvanecido. Nada se sabe quanto à importância da infecção pelo VHG em Portugal. Objectivos: Estudo da prevalência e significado clínico da infecção pelo VHG em doentes portadores de outros vírus, ou hepatites e/ou pertencentes a grupos de risco para hepatites de transmissão parentérica. Doentes e métodos: Estudaram-se 118 doentes (75H, 43M), pertencentes aos seguintes grupos: 18 com hepatite crónica C (I); 17 bebedores excessivos anti-VHC positivos (II); 36 hemodialisados (III), 16 deles com hepatite crónica C (IIIA) e 20 sem anti VHC nem AgHBs (IIIB); 17 transplantados renais com infecção pelo VHC (IV); 18 com hepatite crónica B (V); 10 com hepatite crónica criptogénica (VI); duas com hepatite auto-imune (VII). Onze doentes (7 do grupo I e 4 do II) eram toxicodependentes. Pesquisou-se o ARN-VHG, no soro, por RT-PCR, empregando primers das regiões 5'NC e NS5a, marcados com digoxigenina. Em 56 doentes com hepatite C e em todos os dos grupos V, VI e VII foi feito estudo histológico, cujo resultado se correlacionou com a infecção pelo VHG. Resultados: Em 20 doentes havia ARN-VHG em circulação: 3/18 (16,7%) do grupo I; 2/17 (11,8%) do II; 5/36 (13,9%) do III, 2/16 (12,5%) do IIIA e 3/20 (15%) do IIIB; 6/17 (35,3%) do IV; 4/18 (22,2%) do V. Nenhum doente com hepatite criptogénica ou auto-imune apresentava ARN-VHG. Dos 11 toxicodependentes, 4 (36,4%) apresentavam ARN VHG no soro. Em nove doentes com hepatite C e ARN-VHG biopsados, a actividade necro inflamatória era mínima em 4 e ligeira em 5, havendo fibrose portal em 6; dos quatro com hepatite B e ARN-VHG, um tinha actividade ligeira, sem fibrose e os outros 3 (com consumo alcoólico excessivo) actividade e fibrose graves. Nos três hemodialisados sem outros marcadores de hepatite e com ARN-VHG, as ALT, AST e GGT eram persistentemente normais. Conclusões: A prevalência da infecção pelo VHG foi semelhante (12,5 a 22%) nos diferentes grupos, com excepção dos toxicodependentes (36,4%), transplantados renais (35,3%) e hepatite criptogénica (0%). Os nossos dados sugerem baixa patogenicidade e pouca relevância clínica do VHG, que não vem resolver o problema do diagnóstico etiológico das hepatites criptogénicas. A inter-relação entre o VHG e os vírus das hepatites B e C merece ser melhor estudada. |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://revista.spmi.pt/index.php/rpmi/article/view/2049 |
| dc.language.none.fl_str_mv | por |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Medicina Interna |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | https://creativecommons.org/licenses/by-nc/4.0 |
| dc.source.none.fl_str_mv | Internal Medicine; Vol. 6 No. 2 (1999): Abril/ Junho; 92-97 Medicina Interna; Vol. 6 N.º 2 (1999): Abril/ Junho; 92-97 2183-9980 0872-671X |
| dc.subject.none.fl_str_mv | vírus da hepatites virais hepatite crónica «bepatitis «hepatitis viral hepatitis chronic hepatitis |
| dc.title.fl_str_mv | The prevalence and clinicai significance of "hepatitis" G infection in different groups Prevalência e significado clínico da infecção pelo vírus da "hepatite" G em diversos grupos de doentes |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: The role of HGV /GBV-C in liver pathology, and in association with HCV or HBV infections is not completely understood. HGV infection has not yet been studied in Portugal. Aims: Study of the prevalence and clinicai significance of HGV infection in carriers of HBV or HCV, in patients with chronic hepatitis of unknown aetiology, and in those belonging to some risk groups. Patients and methods: HGV-RNA was determined in serum of 118 patients (75 M, 43 F): 18 with chronic hepatitis C (group I); 17 alcoholics with anti-HCV (group II); 36 chronic haemodialysis patients (group III), 16 of them with chronic hepatitis C (IIIA) and 20 without anti-HCV or HBsAg (IIIB); 17 renal transplant recipients with HCV infection (group IV); 18 chronic hepatitis B patients (group V); 10 with chronic hepatitis with unknown aetiology (group VI); 2 women with autoimmune hepatitis.). Eleven patients {7 of group I and 4 of group II) were drug addicts. HGV-RNA was assessed by RT-PCR, with primers of the 5'NC and NS5a regions, labelled with digoxigenine. Liver histology was assesssed and correlated with HGV infection in 56 chronic hepatitis C patients and in those belonging to groups V, VI and VII. Results: We found HGV-RNA in 20 patients: 3/18 (16.7%); 2/17 (11.8%) of group II; 5/36 (13.9%) of group III, 2/16 (12.5%) of IIIA and 3/20 (15%) of IIIB; 6/17 (35.3%) of the group IV; 4/11 drug addicts (36.4%); none of the patients with cryptogenic or autoimmune hepatitis. Liver histopathology in 9 patients HCV + HGV infections showed minimal activity in 4 and mild in 5; no fibrosis in 3, portal in 6; in 4 HBV +HGV, mild activity and no fibrosis in 1, severe activity and bridging fibrosis in 3 (also alcoholics). The 3 haemodialysed with only HGV infection had normal ALT and GGT. Conclusions: The prevalence of HGV infection was quite similar in most of the studied groups (12.5 to 22%); the exceptions were drug addicts (36.4%), renal transplant patients (35,3%) and those with chronic non-BC hepatitis (0%). Our data suggest little or no pathogenicity of HGV. However, the severity of liver disease in alcoholics with HGV and HBV infections is a remarkable finding. Future studies on the relationship between this and other hepatitis vírus are warranted. |
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| person_str_mv | de Carvalho, Armando Martinho, António Cipriano, Maria Augusta Breda Coimbra, Henriqueta Porto, Armando |
| publishDate | 1999 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Medicina Interna |
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| spelling | en-USThe prevalence and clinicai significance of "hepatitis" G infection in different groupspt-PTPrevalência e significado clínico da infecção pelo vírus da "hepatite" G em diversos grupos de doentesde Carvalho, ArmandoMartinho, AntónioCipriano, Maria AugustaBreda Coimbra, HenriquetaPorto, Armandovírus dahepatites viraishepatite crónica«bepatitis«hepatitisviral hepatitischronic hepatitishttp://purl.org/coar/access_right/c_abf2https://revista.spmi.pt/index.php/rpmi/article/view/2049URLhttps://revista.spmi.pt/index.php/rpmi/article/view/2049URLHasVersionhttps://revista.spmi.pt/index.php/rpmi/article/view/2049/1440URLHasVersion1999-06-30en-USBackground: The role of HGV /GBV-C in liver pathology, and in association with HCV or HBV infections is not completely understood. HGV infection has not yet been studied in Portugal. Aims: Study of the prevalence and clinicai significance of HGV infection in carriers of HBV or HCV, in patients with chronic hepatitis of unknown aetiology, and in those belonging to some risk groups. Patients and methods: HGV-RNA was determined in serum of 118 patients (75 M, 43 F): 18 with chronic hepatitis C (group I); 17 alcoholics with anti-HCV (group II); 36 chronic haemodialysis patients (group III), 16 of them with chronic hepatitis C (IIIA) and 20 without anti-HCV or HBsAg (IIIB); 17 renal transplant recipients with HCV infection (group IV); 18 chronic hepatitis B patients (group V); 10 with chronic hepatitis with unknown aetiology (group VI); 2 women with autoimmune hepatitis.). Eleven patients {7 of group I and 4 of group II) were drug addicts. HGV-RNA was assessed by RT-PCR, with primers of the 5'NC and NS5a regions, labelled with digoxigenine. Liver histology was assesssed and correlated with HGV infection in 56 chronic hepatitis C patients and in those belonging to groups V, VI and VII. Results: We found HGV-RNA in 20 patients: 3/18 (16.7%); 2/17 (11.8%) of group II; 5/36 (13.9%) of group III, 2/16 (12.5%) of IIIA and 3/20 (15%) of IIIB; 6/17 (35.3%) of the group IV; 4/11 drug addicts (36.4%); none of the patients with cryptogenic or autoimmune hepatitis. Liver histopathology in 9 patients HCV + HGV infections showed minimal activity in 4 and mild in 5; no fibrosis in 3, portal in 6; in 4 HBV +HGV, mild activity and no fibrosis in 1, severe activity and bridging fibrosis in 3 (also alcoholics). The 3 haemodialysed with only HGV infection had normal ALT and GGT. Conclusions: The prevalence of HGV infection was quite similar in most of the studied groups (12.5 to 22%); the exceptions were drug addicts (36.4%), renal transplant patients (35,3%) and those with chronic non-BC hepatitis (0%). Our data suggest little or no pathogenicity of HGV. However, the severity of liver disease in alcoholics with HGV and HBV infections is a remarkable finding. Future studies on the relationship between this and other hepatitis vírus are warranted.pt-PTIntrodução: A descoberta de outro vírus hepatotrópico (VHG/VGB-C) trouxe alguma esperança para o esclarecimento das hepatites não A-E, que dados mais recentes têm desvanecido. Nada se sabe quanto à importância da infecção pelo VHG em Portugal. Objectivos: Estudo da prevalência e significado clínico da infecção pelo VHG em doentes portadores de outros vírus, ou hepatites e/ou pertencentes a grupos de risco para hepatites de transmissão parentérica. Doentes e métodos: Estudaram-se 118 doentes (75H, 43M), pertencentes aos seguintes grupos: 18 com hepatite crónica C (I); 17 bebedores excessivos anti-VHC positivos (II); 36 hemodialisados (III), 16 deles com hepatite crónica C (IIIA) e 20 sem anti VHC nem AgHBs (IIIB); 17 transplantados renais com infecção pelo VHC (IV); 18 com hepatite crónica B (V); 10 com hepatite crónica criptogénica (VI); duas com hepatite auto-imune (VII). Onze doentes (7 do grupo I e 4 do II) eram toxicodependentes. Pesquisou-se o ARN-VHG, no soro, por RT-PCR, empregando primers das regiões 5'NC e NS5a, marcados com digoxigenina. Em 56 doentes com hepatite C e em todos os dos grupos V, VI e VII foi feito estudo histológico, cujo resultado se correlacionou com a infecção pelo VHG. Resultados: Em 20 doentes havia ARN-VHG em circulação: 3/18 (16,7%) do grupo I; 2/17 (11,8%) do II; 5/36 (13,9%) do III, 2/16 (12,5%) do IIIA e 3/20 (15%) do IIIB; 6/17 (35,3%) do IV; 4/18 (22,2%) do V. Nenhum doente com hepatite criptogénica ou auto-imune apresentava ARN-VHG. Dos 11 toxicodependentes, 4 (36,4%) apresentavam ARN VHG no soro. Em nove doentes com hepatite C e ARN-VHG biopsados, a actividade necro inflamatória era mínima em 4 e ligeira em 5, havendo fibrose portal em 6; dos quatro com hepatite B e ARN-VHG, um tinha actividade ligeira, sem fibrose e os outros 3 (com consumo alcoólico excessivo) actividade e fibrose graves. Nos três hemodialisados sem outros marcadores de hepatite e com ARN-VHG, as ALT, AST e GGT eram persistentemente normais. Conclusões: A prevalência da infecção pelo VHG foi semelhante (12,5 a 22%) nos diferentes grupos, com excepção dos toxicodependentes (36,4%), transplantados renais (35,3%) e hepatite criptogénica (0%). Os nossos dados sugerem baixa patogenicidade e pouca relevância clínica do VHG, que não vem resolver o problema do diagnóstico etiológico das hepatites criptogénicas. A inter-relação entre o VHG e os vírus das hepatites B e C merece ser melhor estudada.Sociedade Portuguesa de Medicina Internaapplication/pdfen-USInternal Medicine; Vol. 6 No. 2 (1999): Abril/ Junho; 92-97pt-PTMedicina Interna; Vol. 6 N.º 2 (1999): Abril/ Junho; 92-972183-99800872-671Xporjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85https://creativecommons.org/licenses/by-nc/4.0 |
| spellingShingle | The prevalence and clinicai significance of "hepatitis" G infection in different groups de Carvalho, Armando vírus da hepatites virais hepatite crónica «bepatitis «hepatitis viral hepatitis chronic hepatitis |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | vírus da hepatites virais hepatite crónica «bepatitis «hepatitis viral hepatitis chronic hepatitis |
| title | The prevalence and clinicai significance of "hepatitis" G infection in different groups |
| title_full | The prevalence and clinicai significance of "hepatitis" G infection in different groups |
| title_fullStr | The prevalence and clinicai significance of "hepatitis" G infection in different groups |
| title_full_unstemmed | The prevalence and clinicai significance of "hepatitis" G infection in different groups |
| title_short | The prevalence and clinicai significance of "hepatitis" G infection in different groups |
| title_sort | The prevalence and clinicai significance of "hepatitis" G infection in different groups |
| topic | vírus da hepatites virais hepatite crónica «bepatitis «hepatitis viral hepatitis chronic hepatitis |
| topic_facet | vírus da hepatites virais hepatite crónica «bepatitis «hepatitis viral hepatitis chronic hepatitis |
| url | https://revista.spmi.pt/index.php/rpmi/article/view/2049 |
| visible | 1 |