Publicação
Overview on gastroretentive drug delivery systems for improving drug bioavailability
| Resumo: | In recent decades, many efforts have been made in order to improve drug bioavailability after oral administration. Gastroretentive drug delivery systems are a good example; they emerged to enhance the bioavailability and effectiveness of drugs with a narrow absorption window in the upper gastrointestinal tract and/or to promote local activity in the stomach and duodenum. Several strategies are used to increase the gastric residence time, namely bioadhesive or mucoadhesive systems, expandable systems, high-density systems, floating systems, superporous hydrogels and magnetic systems. The present review highlights some of the drugs that can benefit from gastroretentive strategies, such as the factors that influence gastric retention time and the mechanism of action of gastroretentive systems, as well as their classification into single and multiple unit systems. |
|---|---|
| Autores principais: | Lopes, Carla Martins |
| Outros Autores: | Bettencourt, Catarina; Rossi, Alessandra; Buttini, Francesca; Barata, Pedro |
| Assunto: | Narrow absorption window Controlled drug release Gastroretentive system Gastric retention time Multiple unit dosage form |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade Fernando Pessoa |
| Idioma: | inglês |
| Origem: | Repositório Institucional - Universidade Fernando Pessoa |
| _version_ | 1868418674971377664 |
|---|---|
| author | Lopes, Carla Martins |
| author2 | Bettencourt, Catarina Rossi, Alessandra Buttini, Francesca Barata, Pedro |
| author2_role | author author author author |
| author_facet | Lopes, Carla Martins Bettencourt, Catarina Rossi, Alessandra Buttini, Francesca Barata, Pedro |
| author_role | author |
| contributor_name_str_mv | Repositório Institucional da Fernando Pessoa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Lopes, Carla Martins\",\"Person.identifier.orcid\":\"0000-0001-5080-032X\",\"Person.identifier.orcid\":\"0000-0001-5080-032X\"},{\"Person.name\":\"Bettencourt, Catarina\"},{\"Person.name\":\"Rossi, Alessandra\"},{\"Person.name\":\"Buttini, Francesca\"},{\"Person.name\":\"Barata, Pedro\",\"Person.identifier.orcid\":\"0000-0002-4537-5450\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Institucional da Fernando Pessoa |
| datacite.creators.creator.creatorName.fl_str_mv | Lopes, Carla Martins Bettencourt, Catarina Rossi, Alessandra Buttini, Francesca Barata, Pedro |
| datacite.date.Accepted.fl_str_mv | 2016-08-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-09-29T13:54:08Z |
| datacite.date.embargoed.fl_str_mv | 2020-09-29T13:54:08Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Narrow absorption window Controlled drug release Gastroretentive system Gastric retention time Multiple unit dosage form |
| datacite.titles.title.fl_str_mv | Overview on gastroretentive drug delivery systems for improving drug bioavailability |
| dc.contributor.none.fl_str_mv | Repositório Institucional da Fernando Pessoa |
| dc.creator.none.fl_str_mv | Lopes, Carla Martins Bettencourt, Catarina Rossi, Alessandra Buttini, Francesca Barata, Pedro |
| dc.date.Accepted.fl_str_mv | 2016-08-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-09-29T13:54:08Z |
| dc.date.embargoed.fl_str_mv | 2020-09-29T13:54:08Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10284/9010 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Narrow absorption window Controlled drug release Gastroretentive system Gastric retention time Multiple unit dosage form |
| dc.title.fl_str_mv | Overview on gastroretentive drug delivery systems for improving drug bioavailability |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | In recent decades, many efforts have been made in order to improve drug bioavailability after oral administration. Gastroretentive drug delivery systems are a good example; they emerged to enhance the bioavailability and effectiveness of drugs with a narrow absorption window in the upper gastrointestinal tract and/or to promote local activity in the stomach and duodenum. Several strategies are used to increase the gastric residence time, namely bioadhesive or mucoadhesive systems, expandable systems, high-density systems, floating systems, superporous hydrogels and magnetic systems. The present review highlights some of the drugs that can benefit from gastroretentive strategies, such as the factors that influence gastric retention time and the mechanism of action of gastroretentive systems, as well as their classification into single and multiple unit systems. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://bdigital.ufp.pt/bitstreams/07d538ff-ab8f-4644-bee6-267352c6cf38/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10284/9010 |
| instacron_str | ufp |
| institution | Universidade Fernando Pessoa |
| instname_str | Universidade Fernando Pessoa |
| language | eng |
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| network_name_str | Repositório Institucional - Universidade Fernando Pessoa |
| oai_identifier_str | oai:bdigital.ufp.pt:10284/9010 |
| organization_str_mv | urn:organizationAcronym:ufp |
| person_str_mv | Lopes, Carla Martins Lopes, Carla Martins https://www.ciencia-id.pt/901D-160C-633E 901D-160C-633E http://orcid.org/0000-0001-5080-032X 0000-0001-5080-032X http://orcid.org/0000-0001-5080-032X 0000-0001-5080-032X Bettencourt, Catarina Rossi, Alessandra Buttini, Francesca Barata, Pedro Barata, Pedro https://www.ciencia-id.pt/1A18-987D-45C3 1A18-987D-45C3 http://orcid.org/0000-0002-4537-5450 0000-0002-4537-5450 |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório Institucional - Universidade Fernando Pessoa |
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| spelling | engElsevierpt_PTIn recent decades, many efforts have been made in order to improve drug bioavailability after oral administration. Gastroretentive drug delivery systems are a good example; they emerged to enhance the bioavailability and effectiveness of drugs with a narrow absorption window in the upper gastrointestinal tract and/or to promote local activity in the stomach and duodenum. Several strategies are used to increase the gastric residence time, namely bioadhesive or mucoadhesive systems, expandable systems, high-density systems, floating systems, superporous hydrogels and magnetic systems. The present review highlights some of the drugs that can benefit from gastroretentive strategies, such as the factors that influence gastric retention time and the mechanism of action of gastroretentive systems, as well as their classification into single and multiple unit systems.application/pdfpt_PTOverview on gastroretentive drug delivery systems for improving drug bioavailabilityPersonalLopes, Carla MartinsDSpacehttp://dspace.org/items/d2a48cfe-9258-4916-99be-bbcb710f6605DSpacehttp://dspace.org/items/d2a48cfe-9258-4916-99be-bbcb710f6605LopesLopesCarlaCiência IDhttps://www.ciencia-id.pt901D-160C-633EORCIDhttp://orcid.org0000-0001-5080-032XORCIDhttp://orcid.org0000-0001-5080-032XResearcher IDhttps://www.researcherid.comM-4689-2016Researcher IDhttps://www.researcherid.comM-4689-2016Scopus Author IDhttps://www.scopus.com26649517700Scopus Author IDhttps://www.scopus.com26649517700Scopus Author IDhttps://www.scopus.com56526164500Scopus Author IDhttps://www.scopus.com56526164500Bettencourt, CatarinaRossi, AlessandraButtini, FrancescaPersonalBarata, PedroDSpacehttp://dspace.org/items/8d0c119d-146f-4548-9e03-b16d0050ef08DSpacehttp://dspace.org/items/8d0c119d-146f-4548-9e03-b16d0050ef08BarataPedroCiência IDhttps://www.ciencia-id.pt1A18-987D-45C3ORCIDhttp://orcid.org0000-0002-4537-5450Scopus Author IDhttps://www.scopus.com55043534700HostingInstitutionOrganizationalRepositório Institucional da Fernando Pessoae-mailmailto:b-digital@ufp.ptb-digital@ufp.ptISSNIsPartOf0378-5173DOIIsPartOf10.1016/j.ijpharm.2016.05.0162020-09-29T13:54:08Z2016-082020-07-24T15:21:29Z2016-08-01T00:00:00ZHandlehttp://hdl.handle.net/10284/9010http://purl.org/coar/access_right/c_16ecrestricted accessNarrow absorption windowControlled drug releaseGastroretentive systemGastric retention timeMultiple unit dosage form1053425 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://bdigital.ufp.pt/bitstreams/07d538ff-ab8f-4644-bee6-267352c6cf38/downloadInternational Journal of Pharmaceutics510144158 |
| spellingShingle | Overview on gastroretentive drug delivery systems for improving drug bioavailability Lopes, Carla Martins Narrow absorption window Controlled drug release Gastroretentive system Gastric retention time Multiple unit dosage form |
| status | SINGLETON |
| subject.fl_str_mv | Narrow absorption window Controlled drug release Gastroretentive system Gastric retention time Multiple unit dosage form |
| title | Overview on gastroretentive drug delivery systems for improving drug bioavailability |
| title_full | Overview on gastroretentive drug delivery systems for improving drug bioavailability |
| title_fullStr | Overview on gastroretentive drug delivery systems for improving drug bioavailability |
| title_full_unstemmed | Overview on gastroretentive drug delivery systems for improving drug bioavailability |
| title_short | Overview on gastroretentive drug delivery systems for improving drug bioavailability |
| title_sort | Overview on gastroretentive drug delivery systems for improving drug bioavailability |
| topic | Narrow absorption window Controlled drug release Gastroretentive system Gastric retention time Multiple unit dosage form |
| topic_facet | Narrow absorption window Controlled drug release Gastroretentive system Gastric retention time Multiple unit dosage form |
| url | http://hdl.handle.net/10284/9010 |
| visible | 1 |