Publicação
Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345
| Resumo: | The common cold is an acute, self-limiting inflammation of the mucosa of the upper airways, which may involve one or all the sinuses, nasopharynx, oropharynx and larynx. It is common to have at least one episode per year. Common cold symptoms, which may include sore throat, sneezing, nasal congestion, runny nose, headache, malaise and mild fever usually disappear within a few days without treatment. The causative agent of most colds is rhinovirus. Although not associated with mortality, common cold is associated with significant morbidity. There is no vaccine or cure for common cold and, therefore, their treatment is centered on relieving the symptoms. This Cochrane review aimed to synthesize the existing evidence about the clinical benefit of antihistamines, used as monotherapy, compared with placebo or no treatment in children and adult patients with common cold. A total of 18 randomized clinical trials with 4342 participants were included. Main results were: 1) Antihistamines have a small (days one and two) beneficial effect in the short term on the severity of overall symptoms in adult patients, although this effect is not present in the medium to long term; 2) antihistamines were not associated with a clinically significant beneficial effect on the individual symptoms (nasal congestion, rhinorrhea, and sneezing); 3) Antihistamines are not associated with an increased risk of adverse effects; 4) No conclusion can be made about the effectiveness of antihistamines in pediatric populations. Our interpretation of the results is that the available evidence is insufficient to support the prescription or buying OTC antihistamines to relieve the symptoms of common cold without allergic component. |
|---|---|
| Autores principais: | Sterrantino, Carmel |
| Outros Autores: | Duarte, Gonçalo Silva; Costa, João; Carneiro, António Vaz |
| Assunto: | Common cold/drug therapy Histamine H1 antagonists/therapeutic use Systematic review |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1865920780848594944 |
|---|---|
| author | Sterrantino, Carmel |
| author2 | Duarte, Gonçalo Silva Costa, João Carneiro, António Vaz |
| author2_role | author author author |
| author_facet | Sterrantino, Carmel Sterrantino, Carmel Duarte, Gonçalo Silva Costa, João Carneiro, António Vaz Duarte, Gonçalo Silva Costa, João Carneiro, António Vaz |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Sterrantino, Carmel\"},{\"Person.name\":\"Duarte, Gonçalo Silva\",\"Person.identifier.orcid\":\"0000-0001-7802-1897\"},{\"Person.name\":\"Costa, João\",\"Person.identifier.orcid\":\"0000-0002-5831-4921\"},{\"Person.name\":\"Carneiro, António Vaz\",\"Person.identifier.orcid\":\"0000-0002-2783-0544\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Sterrantino, Carmel Duarte, Gonçalo Silva Costa, João Carneiro, António Vaz |
| datacite.date.Accepted.fl_str_mv | 2016-03-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-03-13T15:32:18Z |
| datacite.date.embargoed.fl_str_mv | 2018-03-13T15:32:18Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Common cold/drug therapy Histamine H1 antagonists/therapeutic use Systematic review |
| datacite.titles.title.fl_str_mv | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 Análise da revisão Cochrane : antihistamínicos para a constipação : Cochrane Database Syst Rev. 2015;11:CD009345 |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Sterrantino, Carmel Duarte, Gonçalo Silva Costa, João Carneiro, António Vaz |
| dc.date.Accepted.fl_str_mv | 2016-03-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-03-13T15:32:18Z |
| dc.date.embargoed.fl_str_mv | 2018-03-13T15:32:18Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/32303 |
| dc.language.none.fl_str_mv | por |
| dc.publisher.none.fl_str_mv | Ordem dos Médicos |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Common cold/drug therapy Histamine H1 antagonists/therapeutic use Systematic review |
| dc.title.fl_str_mv | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 Análise da revisão Cochrane : antihistamínicos para a constipação : Cochrane Database Syst Rev. 2015;11:CD009345 |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The common cold is an acute, self-limiting inflammation of the mucosa of the upper airways, which may involve one or all the sinuses, nasopharynx, oropharynx and larynx. It is common to have at least one episode per year. Common cold symptoms, which may include sore throat, sneezing, nasal congestion, runny nose, headache, malaise and mild fever usually disappear within a few days without treatment. The causative agent of most colds is rhinovirus. Although not associated with mortality, common cold is associated with significant morbidity. There is no vaccine or cure for common cold and, therefore, their treatment is centered on relieving the symptoms. This Cochrane review aimed to synthesize the existing evidence about the clinical benefit of antihistamines, used as monotherapy, compared with placebo or no treatment in children and adult patients with common cold. A total of 18 randomized clinical trials with 4342 participants were included. Main results were: 1) Antihistamines have a small (days one and two) beneficial effect in the short term on the severity of overall symptoms in adult patients, although this effect is not present in the medium to long term; 2) antihistamines were not associated with a clinically significant beneficial effect on the individual symptoms (nasal congestion, rhinorrhea, and sneezing); 3) Antihistamines are not associated with an increased risk of adverse effects; 4) No conclusion can be made about the effectiveness of antihistamines in pediatric populations. Our interpretation of the results is that the available evidence is insufficient to support the prescription or buying OTC antihistamines to relieve the symptoms of common cold without allergic component. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/587347f1-6a14-4e69-85cf-f64236598cf2/download |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10451/32303 |
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| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | por |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/32303 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Sterrantino, Carmel Duarte, Gonçalo Silva Duarte, Gonçalo Silva http://orcid.org/0000-0001-7802-1897 0000-0001-7802-1897 Costa, João Costa, João http://orcid.org/0000-0002-5831-4921 0000-0002-5831-4921 Carneiro, António Vaz Carneiro, António Vaz http://orcid.org/0000-0002-2783-0544 0000-0002-2783-0544 |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Ordem dos Médicos |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | porOrdem dos Médicospt_PTThe common cold is an acute, self-limiting inflammation of the mucosa of the upper airways, which may involve one or all the sinuses, nasopharynx, oropharynx and larynx. It is common to have at least one episode per year. Common cold symptoms, which may include sore throat, sneezing, nasal congestion, runny nose, headache, malaise and mild fever usually disappear within a few days without treatment. The causative agent of most colds is rhinovirus. Although not associated with mortality, common cold is associated with significant morbidity. There is no vaccine or cure for common cold and, therefore, their treatment is centered on relieving the symptoms. This Cochrane review aimed to synthesize the existing evidence about the clinical benefit of antihistamines, used as monotherapy, compared with placebo or no treatment in children and adult patients with common cold. A total of 18 randomized clinical trials with 4342 participants were included. Main results were: 1) Antihistamines have a small (days one and two) beneficial effect in the short term on the severity of overall symptoms in adult patients, although this effect is not present in the medium to long term; 2) antihistamines were not associated with a clinically significant beneficial effect on the individual symptoms (nasal congestion, rhinorrhea, and sneezing); 3) Antihistamines are not associated with an increased risk of adverse effects; 4) No conclusion can be made about the effectiveness of antihistamines in pediatric populations. Our interpretation of the results is that the available evidence is insufficient to support the prescription or buying OTC antihistamines to relieve the symptoms of common cold without allergic component.application/pdfpt_PTAnalysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345AlternativeTitlept_PTAnálise da revisão Cochrane : antihistamínicos para a constipação : Cochrane Database Syst Rev. 2015;11:CD009345Sterrantino, CarmelPersonalDuarte, Gonçalo SilvaDSpacehttp://dspace.org/items/06baa442-3f09-4ee2-b0ee-cf3036a26afdDSpacehttp://dspace.org/items/06baa442-3f09-4ee2-b0ee-cf3036a26afdDuarteGonçaloORCIDhttp://orcid.org0000-0001-7802-1897Researcher IDhttps://www.researcherid.comL-4920-2015PersonalCosta, JoãoDSpacehttp://dspace.org/items/0924f405-2d3a-4914-9097-24aa639bd97fDSpacehttp://dspace.org/items/0924f405-2d3a-4914-9097-24aa639bd97fCostaJoãoORCIDhttp://orcid.org0000-0002-5831-4921Scopus Author IDhttps://www.scopus.com55499748300PersonalCarneiro, António VazDSpacehttp://dspace.org/items/376d157f-1127-4663-9d99-038dac28f37dDSpacehttp://dspace.org/items/376d157f-1127-4663-9d99-038dac28f37dVaz CarneiroAntónioORCIDhttp://orcid.org0000-0002-2783-0544Researcher IDhttps://www.researcherid.comL-8026-2013Scopus Author IDhttps://www.scopus.com7006837792HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf1646-0758DOIIsPartOf10.20344/amp.75262018-03-13T15:32:18Z2016-032016-03-01T00:00:00ZHandlehttp://hdl.handle.net/10451/32303http://purl.org/coar/access_right/c_abf2open accessCommon cold/drug therapyHistamine H1 antagonists/therapeutic useSystematic review362665 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/587347f1-6a14-4e69-85cf-f64236598cf2/downloadActa Médica Portuguesa293164167 |
| spellingShingle | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 Sterrantino, Carmel Common cold/drug therapy Histamine H1 antagonists/therapeutic use Systematic review Sterrantino, Carmel Common cold/drug therapy Histamine H1 antagonists/therapeutic use Systematic review |
| status | SINGLETON |
| subject.fl_str_mv | Common cold/drug therapy Histamine H1 antagonists/therapeutic use Systematic review |
| title | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 |
| title_full | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 |
| title_fullStr | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 |
| title_full_unstemmed | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 |
| title_short | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 |
| title_sort | Analysis of the Cochrane review : antihistamines for the common cold : Cochrane Database Syst Rev. 2015;11:CD009345 |
| topic | Common cold/drug therapy Histamine H1 antagonists/therapeutic use Systematic review |
| topic_facet | Common cold/drug therapy Histamine H1 antagonists/therapeutic use Systematic review |
| url | http://hdl.handle.net/10451/32303 |
| visible | 1 |