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In vivo bio-distribution and toxicity evaluation of polymeric and lipid-based nanoparticles : a potential approach for chronic diseases treatment

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Resumo:Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected.
Autores principais:Fonseca-Gomes, João
Outros Autores:Loureiro, Joana A; Tanqueiro, Sara; Mouro, Francisco; Ruivo, Pedro; Carvalho, Tânia; Sebastião, Ana M; Diógenes, Maria José; Pereira, Maria Carmo
Assunto:PLGA nanoparticles Drug delivery systems Liposomes Long-lasting treatment Nanocarriers Solid lipid nanoparticles
Ano:2020
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa

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