Publication
Hepatite A : a propósito de um caso clínico
| Summary: | The HAV is a non-enveloped virus and single-stranded RNA, having an essentially fecal-oral transmission. Over 1.5 million people are infected each year, despite the development of a safe and effective vaccine in the 90s. The disease is forgotten in the developed world but numerous outbreaks are described in Europe and USA. It has a high socioeconomic impact at great cost to public health and cause hospitalization in about 30% of symptomatic patients. The mortality rate reaches 2.1% in adults over 40 years and it can cause fulminant hepatitis in 1% of patients. Portugal is currently a country of low endemicy, with the last outbreak in 2004-2005 with 24 reported cases. The symptomatology is age-dependent. In children, it is essentially asymptomatic and more than 70% of adults present with cholestatic hepatitis and jaundice. The diagnosis is made by detection of anti-HAV IgM. We report the case of a Portuguese patient 35 years, male, residing in Angola since 2003, with severe hepatitis and jaundice, changes in liver tests and modification of the prothrombin time. |
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| Main Authors: | Martins, Soraia Lobo |
| Subject: | Hepatite A Hepatologia |
| Year: | 2014 |
| Country: | Portugal |
| Document type: | master thesis |
| Access type: | restricted access |
| Associated institution: | Universidade de Lisboa |
| Language: | Portuguese |
| Origin: | Repositório da Universidade de Lisboa |
| Summary: | The HAV is a non-enveloped virus and single-stranded RNA, having an essentially fecal-oral transmission. Over 1.5 million people are infected each year, despite the development of a safe and effective vaccine in the 90s. The disease is forgotten in the developed world but numerous outbreaks are described in Europe and USA. It has a high socioeconomic impact at great cost to public health and cause hospitalization in about 30% of symptomatic patients. The mortality rate reaches 2.1% in adults over 40 years and it can cause fulminant hepatitis in 1% of patients. Portugal is currently a country of low endemicy, with the last outbreak in 2004-2005 with 24 reported cases. The symptomatology is age-dependent. In children, it is essentially asymptomatic and more than 70% of adults present with cholestatic hepatitis and jaundice. The diagnosis is made by detection of anti-HAV IgM. We report the case of a Portuguese patient 35 years, male, residing in Angola since 2003, with severe hepatitis and jaundice, changes in liver tests and modification of the prothrombin time. |
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