Publicação

Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acids

Detalhes bibliográficos
Resumo:	Background/Aims: Unconjugated bilirubin (UCB) can be neurotoxic in jaundiced neonates and in patients with Crigler-Najjar syndrome, UCB toxicity may culminate in cell death, however, the occurrence of apoptosis has never been investigated. Ursodeoxycholic
Autores principais:	Silva, RFM
Outros Autores:	Rodrigues, CMP; Brites, D
Assunto:	Gastroenterology & Hepatology
Ano:	2001
País:	Portugal
Tipo de documento:	artigo
Tipo de acesso:	acesso restrito
Instituição associada:	Universidade de Lisboa
Idioma:	inglês
Origem:	Repositório da Universidade de Lisboa

Registos relacionados

Tauroursodeoxycholic acid prevents apoptosis induced by the neurotoxin 3-nitropropionic acid in rat neuronal cells
por: Rodrigues, CMP
Publicado em: (2000)

Steroid nuclear receptors modulate the anti-apoptotic effects of ursodeoxycholic acid in TGF-b1-induced apoptosis of primary rat hepatocytes
por: Sola, S
Publicado em: (2004)

P53 is a specific molecular target of ursodeoxycholic acid in regulating apoptosis
por: Amaral, Joana D.
Publicado em: (2007)

Nuclear steroid receptors modulate cellular trafficking of ursodeoxycholic acid in primary rat hepatocytes
por: Sola, S
Publicado em: (2005)

Ursodeoxycholic acid modulates expression of Bcl-2 family proteins through the p53/MDM-2 pathway in TGF-beta 1-induced hepatocyte apoptosis.
por: Sola, S
Publicado em: (2002)

Differential regulation of cyclin D1 and apoptosis by bile acids in primary rat hepatocytes
por: Castro, R. E.
Publicado em: (2007)

Bile acids differentally regulate cell cycle and apoptosis-related proteins in primary rat hepatocytes
por: Castro, R. E.
Publicado em: (2006)

Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-beta 1-induced apoptosis in rat hepatocytes
por: Sola, S
Publicado em: (2005)

Nuclear translocation of UDCA via the glucocorticoid receptor is essential for inhibiting TGF-FO1-induced apoptosis of rat hepatocytes
por: Sola, S
Publicado em: (2005)

Ability of glycoursodeoxycholate to prevent astrocyte injury by bilirubin may be restricted to the membrane pathway-dependent cytotoxicity
por: Fernandes, A
Publicado em: (2003)

Differential expression of Bcl-2 gene family induced by transforming growth factor beta1 (TGF-beta1) is regulated by ursodeoxycholate (UDC)
por: Sola, S
Publicado em: (2002)

Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes
por: Castro, Rui E.
Publicado em: (2007)

Tauroursodeoxycholate prevents mitochondrial membrane perturbation induced by recombinant Bax protein.
por: Rodrigues, CM
Publicado em: (2000)

Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding
por: Kren, BT
Publicado em: (2001)

Bile acid levels are increased in the liver of patients with steatohepatitis
por: Aranha, Marcia M.
Publicado em: (2008)

Apoptosis is a prominent feature of human alcoholic and non-alcoholic steatohepatitis.
por: Rodrigues, CM
Publicado em: (2001)

Enhanced apoptosis and Bcl-2 protein production in the liver of patients with steatohepatitis
por: Ramalho, RM
Publicado em: (2004)

Liver free fatty acids in human nonalcoholic steatohepatitis (NASH)
por: de Almeida, IT
Publicado em: (2002)

H-pylori Induces Genomic DNA Methylation in Human Gastric Cell Lines
por: Jacinto, O.
Publicado em: (2009)

Gilbert's syndrome in Portuguese population
por: Nunes, AI
Publicado em: (2003)

Genomic methylation and geographic distribution of Helicobacter pylori
por: Vale, F.
Publicado em: (2007)

The Enhancement of Gastric Cell Lines Transfection by Nanoparticles for Oral Vaccine Strategies
por: Goncalves, L. M. D.
Publicado em: (2009)

Search for H-pylori Bacteriophages
por: Vale, F. F.
Publicado em: (2009)

Importance of VacA as an Extra Target on the Design of a Multigenic DNA Vaccine Against H-pylori
por: Carvalho, T.
Publicado em: (2009)

PREVENTIVE EFFECTS OF BILE ACIDS ON BILIRUBIN-INDUCED APOPTOSIS OF HUMAN BRAIN MICROVASCULAR ENDOTHELIAL CELLS
por: Correia, M.
Publicado em: (2009)

Modulation of cell cycle proteins with a role on apoptosis of primary rat hepatocytes by ursodeoxycholic acid
por: Castro, REM
Publicado em: (2005)

p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis
por: Amaral, Joana D.
Publicado em: (2007)

Endocytosis in rat cultured astrocytes is inhibited by unconjugated bilirubin
por: Silva, RFM
Publicado em: (2001)

Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta 1-induced apoptosis of rat hepatocytes
por: Sola, S
Publicado em: (2003)

Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta
por: Serrano, Maria A.
Publicado em: (1998)

Glycoursodeoxycholic acid and interleukin-10 modulate the reactivity of rat cortical astrocytes to unconjugated bilirubin
por: Fernandes, Adelaide
Publicado em: (2007)

Outcomes of endoscopic management of primary and refractory postcholecystectomy biliary leaks in a multicentre review of 178 patients
por: Canena, Jorge
Publicado em: (2015)

Bile Acids and Hepatocyte Apoptosis
por: Rodrigues, Cecília MP
Publicado em: (2003)

Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis
por: Rodrigues, CMP
Publicado em: (2002)

Bilirubin injury to neurons: contribution of oxidative stress and rescue by glycoursodeoxycholic acid
por: Brito, Maria A.
Publicado em: (2008)

p53, a novel molecular target of ursodeoxycholic acid in modulating hepatocyte apoptosis=p53, um novo alvo molecular do ácido ursodesoxicólico na modulação da apoptose em hepátócitos
por: Amaral, JD
Publicado em: (2008)

Bilirubin-induced inflammatory response, glutamate release, and cell death in rat cortical astrocytes are enhanced in younger cells
por: Falcao, AS
Publicado em: (2005)

Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome c release in isolated mitochondria
por: Rodrigues, CMP
Publicado em: (2003)

Predictors for incomplete response to ursodeoxycholic acid in primary biliary cholangitis. Data from a national registry of liver disease
por: Cortez-Pinto, Helena
Publicado em: (2021)

Cytokine production, glutamate release and cell death in rat cultured astrocytes treated with unconjugated bilirubin and LPS
por: Fernandes, A
Publicado em: (2004)