Publicação
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
| Resumo: | Therapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations. |
|---|---|
| Autores principais: | Santos, Filipa |
| Outros Autores: | Pires, David; Anes, Elsa; Duarte, Ana Rita C. |
| Assunto: | Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866811095463755776 |
|---|---|
| author | Santos, Filipa |
| author2 | Pires, David Anes, Elsa Duarte, Ana Rita C. |
| author2_role | author author author |
| author_facet | Santos, Filipa Pires, David Anes, Elsa Duarte, Ana Rita C. |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Santos, Filipa\"},{\"Person.name\":\"Pires, David\",\"Person.identifier.orcid\":\"0000-0001-9602-1516\"},{\"Person.name\":\"Anes, Elsa\",\"Person.identifier.orcid\":\"0000-0001-5934-0198\"},{\"Person.name\":\"Duarte, Ana Rita C.\",\"Person.identifier.orcid\":\"0000-0003-0800-0112\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Santos, Filipa Pires, David Anes, Elsa Duarte, Ana Rita C. |
| datacite.date.Accepted.fl_str_mv | 2023-03-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-08-24T16:23:04Z |
| datacite.date.embargoed.fl_str_mv | 2023-08-24T16:23:04Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
| datacite.titles.title.fl_str_mv | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Santos, Filipa Pires, David Anes, Elsa Duarte, Ana Rita C. |
| dc.date.Accepted.fl_str_mv | 2023-03-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-08-24T16:23:04Z |
| dc.date.embargoed.fl_str_mv | 2023-08-24T16:23:04Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/59009 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
| dc.title.fl_str_mv | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Therapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/e65e7a3d-0d62-4515-8036-20622bf10ef4/download |
| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID 6817 - DCRRNI ID |
| id | ul_47f09f074e2ebc0300d111b9fceb897a |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/59009 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/59009 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Santos, Filipa Pires, David Pires, David https://www.ciencia-id.pt/5816-D53E-F354 5816-D53E-F354 http://orcid.org/0000-0001-9602-1516 0000-0001-9602-1516 Anes, Elsa Anes, Elsa https://www.ciencia-id.pt/1A10-7DAD-D860 1A10-7DAD-D860 http://orcid.org/0000-0001-5934-0198 0000-0001-5934-0198 Duarte, Ana Rita C. Duarte, Ana Rita C. https://www.ciencia-id.pt/EC16-491B-8A13 EC16-491B-8A13 http://orcid.org/0000-0003-0800-0112 0000-0003-0800-0112 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engElsevierpt_PTTherapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to treatment and the development of drug resistance. During this study, it was possible to assess the physicochemical stability of the formulations for 6 months, by polarized optical microscopy, 1H NMR and FTIR-ATR. Furthermore, the mixtures present an antibacterial effect against a drug-susceptible Mycobacterium tuberculosis strain (H37Rv). This was particularly evident for the mixtures with ethambutol incorporated, making them interesting to pursue with further studies and evaluation of clinical applicability. Upon infection, it was also observed that a single and higher dose appears to be more effective than lower separate doses, which could allow the production of patient-friendly formulations.application/pdfpt_PTInsights into therapeutic liquid mixtures and formulations towards tuberculosis therapySantos, FilipaPersonalPires, DavidDSpacehttp://dspace.org/items/33f8bd0a-4d69-4202-a087-a8de16eb2168DSpacehttp://dspace.org/items/33f8bd0a-4d69-4202-a087-a8de16eb2168RODRIGUES PIRESDAVID ALEXANDRECiência IDhttps://www.ciencia-id.pt5816-D53E-F354ORCIDhttp://orcid.org0000-0001-9602-1516Scopus Author IDhttps://www.scopus.com50162243000PersonalAnes, ElsaDSpacehttp://dspace.org/items/8a820e65-a46a-4617-99a6-c2f0a88e1103DSpacehttp://dspace.org/items/8a820e65-a46a-4617-99a6-c2f0a88e1103RIBEIRO DOS SANTOS ANESELSA MARIACiência IDhttps://www.ciencia-id.pt1A10-7DAD-D860ORCIDhttp://orcid.org0000-0001-5934-0198Scopus Author IDhttps://www.scopus.com6507064447PersonalDuarte, Ana Rita C.DSpacehttp://dspace.org/items/1284713d-8806-4798-9837-714d3d853685DSpacehttp://dspace.org/items/1284713d-8806-4798-9837-714d3d853685DuarteAnaCiência IDhttps://www.ciencia-id.ptEC16-491B-8A13ORCIDhttp://orcid.org0000-0003-0800-0112Scopus Author IDhttps://www.scopus.com7102601957Scopus Author IDhttps://www.scopus.com7102601957HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0378-5173DOIIsPartOf10.1016/j.ijpharm.2023.1228622023-08-24T16:23:04Z2023-032023-06-02T16:31:52Z2023-03-01T00:00:00ZHandlehttp://hdl.handle.net/10451/59009http://purl.org/coar/access_right/c_abf2open accessAnti-tuberculosis drugsEutectic mixturesTherapeutic liquid mixturesTuberculosis2126029 bytesFundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processes6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaResearch Institute for Medicines6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2023-03http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/e65e7a3d-0d62-4515-8036-20622bf10ef4/downloadInternational Journal of Pharmaceutics637122862 |
| spellingShingle | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy Santos, Filipa Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
| status | SINGLETON |
| subject.fl_str_mv | Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
| title | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
| title_full | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
| title_fullStr | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
| title_full_unstemmed | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
| title_short | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
| title_sort | Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy |
| topic | Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
| topic_facet | Anti-tuberculosis drugs Eutectic mixtures Therapeutic liquid mixtures Tuberculosis |
| url | http://hdl.handle.net/10451/59009 |
| visible | 1 |