Publicação
ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study
| Resumo: | Chronic hepatitis C (CHC) progression is highly variable and can be influenced by lipid metabolism. The ATP-binding cassette transporter A1 (ABCA1) is involved in lipid metabolism and mediates cholesterol efflux from liver cells. ABCA1 gene polymorphism rs2230808 (R1587K) modulates lipid levels as it is located in an ABCA1 protein domain, which is essential for cholesterol efflux. We aimed to analyze the role of ABCA1 polymorphism R1587K (rs2230808) in modulating the biochemical parameters of lipid metabolism and liver function and its association with liver disease severity, according to gender. A total of 161 CHC patients were clinically, histologically, and biochemically evaluated. Genotyping was performed by melting-curve analysis and statistical analysis by SPSS 24.0. There were significant differences between ABCA1_rs2230808 genotypes and total cholesterol, γGT (γ-glutamyl-transpeptidase), and HCV-RNA. Gender differences: in females, ABCA1_rs2230808 (GG or GA) was associated with higher HCV-RNA serum levels; in males, ABCA1_rs2230808 (GG or GA) was associated with higher γGT, lower total cholesterol, increased risk for γGT ≥ 38 UI/L, and total cholesterol < 4.92 mmol/L. Only in the case of males were higher γGT and lower total cholesterol associated with severe fibrosis and steatosis. Total cholesterol < 4.92 mmol/L also associates with severe necroinflammation. We conclude that ABCA1_rs2230808 is gender-specific. ABCA1_rs2230808 Allele G was associated with different clinical and biochemical parameters, which are related to more severe liver disease. |
|---|---|
| Autores principais: | Ferreira, Joana |
| Outros Autores: | Bicho, Manuel; Serejo, Fátima |
| Assunto: | ATP binding cassette transporter A1 Chronic hepatitis C Fibrosis Genetic polymorphism |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866809994728439808 |
|---|---|
| author | Ferreira, Joana |
| author2 | Bicho, Manuel Serejo, Fátima |
| author2_role | author author |
| author_facet | Ferreira, Joana Bicho, Manuel Serejo, Fátima |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ferreira, Joana\",\"Person.identifier.orcid\":\"0000-0002-3527-3274\"},{\"Person.name\":\"Bicho, Manuel\",\"Person.identifier.orcid\":\"0000-0002-5773-5687\"},{\"Person.name\":\"Serejo, Fátima\",\"Person.identifier.orcid\":\"0000-0002-1541-843X\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Ferreira, Joana Bicho, Manuel Serejo, Fátima |
| datacite.date.Accepted.fl_str_mv | 2022-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-11-14T16:23:46Z |
| datacite.date.embargoed.fl_str_mv | 2023-11-14T16:23:46Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | ATP binding cassette transporter A1 Chronic hepatitis C Fibrosis Genetic polymorphism |
| datacite.titles.title.fl_str_mv | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Ferreira, Joana Bicho, Manuel Serejo, Fátima |
| dc.date.Accepted.fl_str_mv | 2022-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-11-14T16:23:46Z |
| dc.date.embargoed.fl_str_mv | 2023-11-14T16:23:46Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/60546 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | ATP binding cassette transporter A1 Chronic hepatitis C Fibrosis Genetic polymorphism |
| dc.title.fl_str_mv | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Chronic hepatitis C (CHC) progression is highly variable and can be influenced by lipid metabolism. The ATP-binding cassette transporter A1 (ABCA1) is involved in lipid metabolism and mediates cholesterol efflux from liver cells. ABCA1 gene polymorphism rs2230808 (R1587K) modulates lipid levels as it is located in an ABCA1 protein domain, which is essential for cholesterol efflux. We aimed to analyze the role of ABCA1 polymorphism R1587K (rs2230808) in modulating the biochemical parameters of lipid metabolism and liver function and its association with liver disease severity, according to gender. A total of 161 CHC patients were clinically, histologically, and biochemically evaluated. Genotyping was performed by melting-curve analysis and statistical analysis by SPSS 24.0. There were significant differences between ABCA1_rs2230808 genotypes and total cholesterol, γGT (γ-glutamyl-transpeptidase), and HCV-RNA. Gender differences: in females, ABCA1_rs2230808 (GG or GA) was associated with higher HCV-RNA serum levels; in males, ABCA1_rs2230808 (GG or GA) was associated with higher γGT, lower total cholesterol, increased risk for γGT ≥ 38 UI/L, and total cholesterol < 4.92 mmol/L. Only in the case of males were higher γGT and lower total cholesterol associated with severe fibrosis and steatosis. Total cholesterol < 4.92 mmol/L also associates with severe necroinflammation. We conclude that ABCA1_rs2230808 is gender-specific. ABCA1_rs2230808 Allele G was associated with different clinical and biochemical parameters, which are related to more severe liver disease. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/5c5566ea-aa5f-4ce1-9964-94a9a1a501a1/download |
| funding.funder.alternateName_str_mv | FCT FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID 6817 - DCRRNI ID |
| id | ul_480d287635861806da1dc5e2fbb2d581 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/60546 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/60546 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Ferreira, Joana Ferreira, Joana http://orcid.org/0000-0002-3527-3274 0000-0002-3527-3274 Bicho, Manuel Bicho, Manuel https://www.ciencia-id.pt/9512-8D22-1B28 9512-8D22-1B28 http://orcid.org/0000-0002-5773-5687 0000-0002-5773-5687 Serejo, Fátima Serejo, Fátima http://orcid.org/0000-0002-1541-843X 0000-0002-1541-843X |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engMDPIpt_PTChronic hepatitis C (CHC) progression is highly variable and can be influenced by lipid metabolism. The ATP-binding cassette transporter A1 (ABCA1) is involved in lipid metabolism and mediates cholesterol efflux from liver cells. ABCA1 gene polymorphism rs2230808 (R1587K) modulates lipid levels as it is located in an ABCA1 protein domain, which is essential for cholesterol efflux. We aimed to analyze the role of ABCA1 polymorphism R1587K (rs2230808) in modulating the biochemical parameters of lipid metabolism and liver function and its association with liver disease severity, according to gender. A total of 161 CHC patients were clinically, histologically, and biochemically evaluated. Genotyping was performed by melting-curve analysis and statistical analysis by SPSS 24.0. There were significant differences between ABCA1_rs2230808 genotypes and total cholesterol, γGT (γ-glutamyl-transpeptidase), and HCV-RNA. Gender differences: in females, ABCA1_rs2230808 (GG or GA) was associated with higher HCV-RNA serum levels; in males, ABCA1_rs2230808 (GG or GA) was associated with higher γGT, lower total cholesterol, increased risk for γGT ≥ 38 UI/L, and total cholesterol < 4.92 mmol/L. Only in the case of males were higher γGT and lower total cholesterol associated with severe fibrosis and steatosis. Total cholesterol < 4.92 mmol/L also associates with severe necroinflammation. We conclude that ABCA1_rs2230808 is gender-specific. ABCA1_rs2230808 Allele G was associated with different clinical and biochemical parameters, which are related to more severe liver disease.application/pdfpt_PTABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary studyPersonalFerreira, JoanaDSpacehttp://dspace.org/items/ebc5ecec-0ac3-41e7-9789-e1a0ed2ac731DSpacehttp://dspace.org/items/ebc5ecec-0ac3-41e7-9789-e1a0ed2ac731FerreiraJoanaORCIDhttp://orcid.org0000-0002-3527-3274PersonalBicho, ManuelDSpacehttp://dspace.org/items/c61e4f7e-28b3-47b4-bc5d-677b73fc3aecDSpacehttp://dspace.org/items/c61e4f7e-28b3-47b4-bc5d-677b73fc3aecBichoManuelCiência IDhttps://www.ciencia-id.pt9512-8D22-1B28ORCIDhttp://orcid.org0000-0002-5773-5687Scopus Author IDhttps://www.scopus.com7004153755PersonalSerejo, FátimaDSpacehttp://dspace.org/items/afdaf48a-b6c1-4a19-93aa-2eecdd557621DSpacehttp://dspace.org/items/afdaf48a-b6c1-4a19-93aa-2eecdd557621SerejoMaria de FátimaORCIDhttp://orcid.org0000-0002-1541-843XScopus Author IDhttps://www.scopus.com6603429434HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptDOIIsPartOf10.3390/genes131120952023-11-14T16:23:46Z20222022-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/60546http://purl.org/coar/access_right/c_abf2open accessATP binding cassette transporter A1Chronic hepatitis CFibrosisGenetic polymorphism284421 bytesFundação para a Ciência e a TecnologiaImplications of long term VHC elimination in cardiometabolic profile and hepatic disease of chroni hepatitis C patientsCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaEnvironmental Health Institute6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaEnvironmental Health Institute6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2022http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/5c5566ea-aa5f-4ce1-9964-94a9a1a501a1/downloadGenes1311 |
| spellingShingle | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study Ferreira, Joana ATP binding cassette transporter A1 Chronic hepatitis C Fibrosis Genetic polymorphism |
| status | SINGLETON |
| subject.fl_str_mv | ATP binding cassette transporter A1 Chronic hepatitis C Fibrosis Genetic polymorphism |
| title | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study |
| title_full | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study |
| title_fullStr | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study |
| title_full_unstemmed | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study |
| title_short | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study |
| title_sort | ABCA1 polymorphism R1587K in chronic hepatitis C Is gender-specific and modulates liver disease severity through its influence on cholesterol metabolism and liver function: a preliminary study |
| topic | ATP binding cassette transporter A1 Chronic hepatitis C Fibrosis Genetic polymorphism |
| topic_facet | ATP binding cassette transporter A1 Chronic hepatitis C Fibrosis Genetic polymorphism |
| url | http://hdl.handle.net/10451/60546 |
| visible | 1 |