Publicação
Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era
| Resumo: | Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease that ultimately leads to joint destruction and functional disability. Although the exact etiology of RA is not fully understood, it is well established that gut microbiota (GM) plays a vital role in the pathogenesis of RA, with accumulating evidence suggesting that gut dysbiosis induces a chronic inflammatory response that may be linked to disease development. Of interest, patients with RA have significant changes in the intestinal microbiota compared to healthy controls, and several studies have suggested the use of probiotics as a possible adjuvant therapy for RA. Benefits of probiotic supplementation were reported in animal models of arthritis and human studies, but the current evidence regarding the effect of probiotic supplementation in the management of RA remains insufficient to make definite recommendations. Several different strains of Lactobacillus and Bifidobacteria, as single species or in mixed culture, have been investigated, and some have demonstrated beneficial effects on disease activity in RA human subjects. As of now, L.casei probiotic bacteria seems to be the strongest candidate for application as adjuvant therapy for RA patients. In this review, we highlight the role of GM in the development and progression of RA and summarize the current knowledge on the use of probiotics as a potential adjuvant therapy for RA. We also review the proposed mechanisms whereby probiotics regulate inflammation. Finally, the role of fermented foods is discussed as a possible alternative to probiotic supplements since they have also been reported to have health benefits. |
|---|---|
| Autores principais: | Ferro, Margarida |
| Outros Autores: | Charneca, Sofia; Dourado, Eduardo; Guerreiro, Catarina Sousa; Fonseca, João Eurico |
| Assunto: | Autoimmunity Dysbiosis Fermented foods Inflammation Rheumatology |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866810983910998016 |
|---|---|
| author | Ferro, Margarida |
| author2 | Charneca, Sofia Dourado, Eduardo Guerreiro, Catarina Sousa Fonseca, João Eurico |
| author2_role | author author author author |
| author_facet | Ferro, Margarida Charneca, Sofia Dourado, Eduardo Guerreiro, Catarina Sousa Fonseca, João Eurico |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ferro, Margarida\",\"Person.identifier.orcid\":\"0000-0002-7549-2391\"},{\"Person.name\":\"Charneca, Sofia\"},{\"Person.name\":\"Dourado, Eduardo\",\"Person.identifier.orcid\":\"0000-0003-2186-2833\"},{\"Person.name\":\"Guerreiro, Catarina Sousa\",\"Person.identifier.orcid\":\"0000-0002-8730-6517\"},{\"Person.name\":\"Fonseca, João Eurico\",\"Person.identifier.orcid\":\"0000-0003-1432-3671\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Ferro, Margarida Charneca, Sofia Dourado, Eduardo Guerreiro, Catarina Sousa Fonseca, João Eurico |
| datacite.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-10-28T14:32:59Z |
| datacite.date.embargoed.fl_str_mv | 2021-10-28T14:32:59Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Autoimmunity Dysbiosis Fermented foods Inflammation Rheumatology |
| datacite.titles.title.fl_str_mv | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Ferro, Margarida Charneca, Sofia Dourado, Eduardo Guerreiro, Catarina Sousa Fonseca, João Eurico |
| dc.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-10-28T14:32:59Z |
| dc.date.embargoed.fl_str_mv | 2021-10-28T14:32:59Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/50049 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Frontiers |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Autoimmunity Dysbiosis Fermented foods Inflammation Rheumatology |
| dc.title.fl_str_mv | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease that ultimately leads to joint destruction and functional disability. Although the exact etiology of RA is not fully understood, it is well established that gut microbiota (GM) plays a vital role in the pathogenesis of RA, with accumulating evidence suggesting that gut dysbiosis induces a chronic inflammatory response that may be linked to disease development. Of interest, patients with RA have significant changes in the intestinal microbiota compared to healthy controls, and several studies have suggested the use of probiotics as a possible adjuvant therapy for RA. Benefits of probiotic supplementation were reported in animal models of arthritis and human studies, but the current evidence regarding the effect of probiotic supplementation in the management of RA remains insufficient to make definite recommendations. Several different strains of Lactobacillus and Bifidobacteria, as single species or in mixed culture, have been investigated, and some have demonstrated beneficial effects on disease activity in RA human subjects. As of now, L.casei probiotic bacteria seems to be the strongest candidate for application as adjuvant therapy for RA patients. In this review, we highlight the role of GM in the development and progression of RA and summarize the current knowledge on the use of probiotics as a potential adjuvant therapy for RA. We also review the proposed mechanisms whereby probiotics regulate inflammation. Finally, the role of fermented foods is discussed as a possible alternative to probiotic supplements since they have also been reported to have health benefits. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/1efa827c-c88a-46ad-936c-a781242fefc8/download |
| id | ul_4b287c235f0fe3bc751cfc7c56596cba |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/50049 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/50049 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Ferro, Margarida Ferro, Margarida https://www.ciencia-id.pt/B111-4ED5-F8E6 B111-4ED5-F8E6 http://orcid.org/0000-0002-7549-2391 0000-0002-7549-2391 Charneca, Sofia Dourado, Eduardo Dourado, Eduardo https://www.ciencia-id.pt/531B-BA03-FCA0 531B-BA03-FCA0 http://orcid.org/0000-0003-2186-2833 0000-0003-2186-2833 Guerreiro, Catarina Sousa Guerreiro, Catarina Sousa https://www.ciencia-id.pt/311F-89E5-532C 311F-89E5-532C http://orcid.org/0000-0002-8730-6517 0000-0002-8730-6517 Fonseca, João Eurico Fonseca, João Eurico https://www.ciencia-id.pt/F310-B85D-57C7 F310-B85D-57C7 http://orcid.org/0000-0003-1432-3671 0000-0003-1432-3671 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Frontiers |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engFrontierspt_PTRheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease that ultimately leads to joint destruction and functional disability. Although the exact etiology of RA is not fully understood, it is well established that gut microbiota (GM) plays a vital role in the pathogenesis of RA, with accumulating evidence suggesting that gut dysbiosis induces a chronic inflammatory response that may be linked to disease development. Of interest, patients with RA have significant changes in the intestinal microbiota compared to healthy controls, and several studies have suggested the use of probiotics as a possible adjuvant therapy for RA. Benefits of probiotic supplementation were reported in animal models of arthritis and human studies, but the current evidence regarding the effect of probiotic supplementation in the management of RA remains insufficient to make definite recommendations. Several different strains of Lactobacillus and Bifidobacteria, as single species or in mixed culture, have been investigated, and some have demonstrated beneficial effects on disease activity in RA human subjects. As of now, L.casei probiotic bacteria seems to be the strongest candidate for application as adjuvant therapy for RA patients. In this review, we highlight the role of GM in the development and progression of RA and summarize the current knowledge on the use of probiotics as a potential adjuvant therapy for RA. We also review the proposed mechanisms whereby probiotics regulate inflammation. Finally, the role of fermented foods is discussed as a possible alternative to probiotic supplements since they have also been reported to have health benefits.application/pdfpt_PTProbiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome eraPersonalFerro, MargaridaDSpacehttp://dspace.org/items/08686949-1e8c-482a-8078-ce208285cb1aDSpacehttp://dspace.org/items/08686949-1e8c-482a-8078-ce208285cb1aFerroMargaridaCiência IDhttps://www.ciencia-id.ptB111-4ED5-F8E6ORCIDhttp://orcid.org0000-0002-7549-2391Charneca, SofiaPersonalDourado, EduardoDSpacehttp://dspace.org/items/6ea62930-47c0-4ac2-a51c-7122f1f570a5DSpacehttp://dspace.org/items/6ea62930-47c0-4ac2-a51c-7122f1f570a5DOURADO DOMINGUESEDUARDO JORGECiência IDhttps://www.ciencia-id.pt531B-BA03-FCA0ORCIDhttp://orcid.org0000-0003-2186-2833PersonalGuerreiro, Catarina SousaDSpacehttp://dspace.org/items/cd573b0e-731c-474b-b158-6d9cf011289bDSpacehttp://dspace.org/items/cd573b0e-731c-474b-b158-6d9cf011289bsousa guerreirocatarinaCiência IDhttps://www.ciencia-id.pt311F-89E5-532CORCIDhttp://orcid.org0000-0002-8730-6517PersonalFonseca, João EuricoDSpacehttp://dspace.org/items/1772dc12-7c55-4c76-ae2d-c23270172480DSpacehttp://dspace.org/items/1772dc12-7c55-4c76-ae2d-c23270172480FonsecaJoãoCiência IDhttps://www.ciencia-id.ptF310-B85D-57C7ORCIDhttp://orcid.org0000-0003-1432-3671Scopus Author IDhttps://www.scopus.com7101983519Scopus Author IDhttps://www.scopus.com55881559500HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptDOIIsPartOf10.3389/fphar.2021.7117882021-10-28T14:32:59Z20212021-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/50049http://purl.org/coar/access_right/c_abf2open accessAutoimmunityDysbiosisFermented foodsInflammationRheumatology1491559 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2021http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/1efa827c-c88a-46ad-936c-a781242fefc8/downloadFrontiers in Pharmacology12 |
| spellingShingle | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era Ferro, Margarida Autoimmunity Dysbiosis Fermented foods Inflammation Rheumatology |
| status | SINGLETON |
| subject.fl_str_mv | Autoimmunity Dysbiosis Fermented foods Inflammation Rheumatology |
| title | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era |
| title_full | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era |
| title_fullStr | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era |
| title_full_unstemmed | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era |
| title_short | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era |
| title_sort | Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era |
| topic | Autoimmunity Dysbiosis Fermented foods Inflammation Rheumatology |
| topic_facet | Autoimmunity Dysbiosis Fermented foods Inflammation Rheumatology |
| url | http://hdl.handle.net/10451/50049 |
| visible | 1 |