Publicação
Advances in understanding molecular regulation of innate immune memory
| Resumo: | The epigenetic and functional reprogramming of immune genes during induction of trained immunity is accompanied by the metabolic rewiring of cellular state. This memory is induced in the hematopoietic niche and propagated to daughter cells, generating epigenetically and metabolically reprogrammed innate immune cells that are greatly enhanced in their capacity to resolve inflammation. In particular, these cells show accumulation of H3K4me3 and H3K27Ac epigenetic marks on multiple immune gene promoters and associated enhancers. However, the mechanism governing how these epigenetic marks accumulate at discrete immune gene loci has been poorly understood, until now. Here, we discuss some recent advances in the regulation of trained immunity, with a particular focus on the mechanistic role of a novel class of long non-coding RNAs in the establishment of epigenetic marks on trained immune gene promoters. |
|---|---|
| Autores principais: | Domínguez-Andrés, Jorge |
| Outros Autores: | Fanucchi, Stephanie; Joosten, Leo A.B.; Mhlanga, Musa; Netea, Mihai G. |
| Assunto: | Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866810300768976896 |
|---|---|
| author | Domínguez-Andrés, Jorge |
| author2 | Fanucchi, Stephanie Joosten, Leo A.B. Mhlanga, Musa Netea, Mihai G. |
| author2_role | author author author author |
| author_facet | Domínguez-Andrés, Jorge Fanucchi, Stephanie Joosten, Leo A.B. Mhlanga, Musa Netea, Mihai G. |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Domínguez-Andrés, Jorge\"},{\"Person.name\":\"Fanucchi, Stephanie\"},{\"Person.name\":\"Joosten, Leo A.B.\"},{\"Person.name\":\"Mhlanga, Musa\",\"Person.identifier.orcid\":\"0000-0003-1381-3409\"},{\"Person.name\":\"Netea, Mihai G.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Domínguez-Andrés, Jorge Fanucchi, Stephanie Joosten, Leo A.B. Mhlanga, Musa Netea, Mihai G. |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-10-15T13:40:18Z |
| datacite.date.embargoed.fl_str_mv | 2021-10-15T13:40:18Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
| datacite.titles.title.fl_str_mv | Advances in understanding molecular regulation of innate immune memory |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Domínguez-Andrés, Jorge Fanucchi, Stephanie Joosten, Leo A.B. Mhlanga, Musa Netea, Mihai G. |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-10-15T13:40:18Z |
| dc.date.embargoed.fl_str_mv | 2021-10-15T13:40:18Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/49906 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
| dc.title.fl_str_mv | Advances in understanding molecular regulation of innate immune memory |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The epigenetic and functional reprogramming of immune genes during induction of trained immunity is accompanied by the metabolic rewiring of cellular state. This memory is induced in the hematopoietic niche and propagated to daughter cells, generating epigenetically and metabolically reprogrammed innate immune cells that are greatly enhanced in their capacity to resolve inflammation. In particular, these cells show accumulation of H3K4me3 and H3K27Ac epigenetic marks on multiple immune gene promoters and associated enhancers. However, the mechanism governing how these epigenetic marks accumulate at discrete immune gene loci has been poorly understood, until now. Here, we discuss some recent advances in the regulation of trained immunity, with a particular focus on the mechanistic role of a novel class of long non-coding RNAs in the establishment of epigenetic marks on trained immune gene promoters. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/ba547c84-360c-42ce-98ca-faa2a146659d/download |
| id | ul_4e99a3ec8a151d3b39501f9cc10d0fa7 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/49906 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/49906 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Domínguez-Andrés, Jorge Fanucchi, Stephanie Joosten, Leo A.B. Mhlanga, Musa Mhlanga, Musa http://orcid.org/0000-0003-1381-3409 0000-0003-1381-3409 Netea, Mihai G. |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engElsevierpt_PTThe epigenetic and functional reprogramming of immune genes during induction of trained immunity is accompanied by the metabolic rewiring of cellular state. This memory is induced in the hematopoietic niche and propagated to daughter cells, generating epigenetically and metabolically reprogrammed innate immune cells that are greatly enhanced in their capacity to resolve inflammation. In particular, these cells show accumulation of H3K4me3 and H3K27Ac epigenetic marks on multiple immune gene promoters and associated enhancers. However, the mechanism governing how these epigenetic marks accumulate at discrete immune gene loci has been poorly understood, until now. Here, we discuss some recent advances in the regulation of trained immunity, with a particular focus on the mechanistic role of a novel class of long non-coding RNAs in the establishment of epigenetic marks on trained immune gene promoters.application/pdfpt_PTAdvances in understanding molecular regulation of innate immune memoryDomínguez-Andrés, JorgeFanucchi, StephanieJoosten, Leo A.B.PersonalMhlanga, MusaDSpacehttp://dspace.org/items/8aa5f7f2-ad5d-4274-b6f0-a9e3684795c3DSpacehttp://dspace.org/items/8aa5f7f2-ad5d-4274-b6f0-a9e3684795c3MhlangaMusaORCIDhttp://orcid.org0000-0003-1381-3409Researcher IDhttps://www.researcherid.comD-1283-2011Netea, Mihai G.HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0955-0674DOIIsPartOf10.1016/j.ceb.2019.12.0062021-10-15T13:40:18Z20202020-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/49906http://purl.org/coar/access_right/c_abf2open accessEpigeneticsInnate memoryMacrophagesMetabolismMonocytesStem cellsTADsTrained immunitylncRNA2128894 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/ba547c84-360c-42ce-98ca-faa2a146659d/downloadCurrent Opinion in Cell Biology636875 |
| spellingShingle | Advances in understanding molecular regulation of innate immune memory Domínguez-Andrés, Jorge Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
| status | SINGLETON |
| subject.fl_str_mv | Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
| title | Advances in understanding molecular regulation of innate immune memory |
| title_full | Advances in understanding molecular regulation of innate immune memory |
| title_fullStr | Advances in understanding molecular regulation of innate immune memory |
| title_full_unstemmed | Advances in understanding molecular regulation of innate immune memory |
| title_short | Advances in understanding molecular regulation of innate immune memory |
| title_sort | Advances in understanding molecular regulation of innate immune memory |
| topic | Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
| topic_facet | Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
| url | http://hdl.handle.net/10451/49906 |
| visible | 1 |