Publicação
Mitoses in cutaneous malignant melanomas : relevance in the prognosis
| Resumo: | Malignant Melanoma is considered the most dangerous skin neoplasia for its potential to invade distant tissues and its associated mortality. Its incidence is considered epidemic. Mitotic rate was recently introduced in the AJCC guidelines as the 2nd most important prognostic factor for thin stage I melanomas, after tumoral thickness, as it strongly correlates with a lower survival rate. Together with ulceration, this variable changes the classification of thin tumors (≤1mm) from T1a to T1b, if at least one mitosis/ mm2 is present. This implies an alteration in patients’ management and treatment. It has been a target of discussion for its accuracy among clinicians and interobserver disparities. The cutoff of one mitosis as also been targeted, since mitotic figures can be found in benign lesions, particularly when immunohistochemistry is used. Mitotic rate has been used to refer patients to sentinel lymph node biopsy, which has also been a disagreement point. Immunohistochemistry in mitoses detection is still under investigation but it is proved to facilitate the observation, although having some objections. Standardization is essential to a more reliable method and adequate patient’s maneuver. |
|---|---|
| Autores principais: | Marques, Sara Completo, 1992- |
| Assunto: | Melanócito Melanoma Mitose Índice mitótico Biópsia de gânglio sentinela Imuno-histoquímica |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1865920801888272384 |
|---|---|
| author | Marques, Sara Completo, 1992- |
| author_facet | Marques, Sara Completo, 1992- Marques, Sara Completo, 1992- |
| author_role | author |
| contributor_name_str_mv | Almeida, Luís Soares de Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Marques, Sara Completo, 1992-\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Almeida, Luís Soares de Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Marques, Sara Completo, 1992- |
| datacite.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2017-10-30T15:28:06Z |
| datacite.date.embargoed.fl_str_mv | 2017-10-30T15:28:06Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Melanócito Melanoma Mitose Índice mitótico Biópsia de gânglio sentinela Imuno-histoquímica |
| datacite.titles.title.fl_str_mv | Mitoses in cutaneous malignant melanomas : relevance in the prognosis |
| dc.contributor.none.fl_str_mv | Almeida, Luís Soares de Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Marques, Sara Completo, 1992- |
| dc.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2017-10-30T15:28:06Z |
| dc.date.embargoed.fl_str_mv | 2017-10-30T15:28:06Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/29481 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Melanócito Melanoma Mitose Índice mitótico Biópsia de gânglio sentinela Imuno-histoquímica |
| dc.title.fl_str_mv | Mitoses in cutaneous malignant melanomas : relevance in the prognosis |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_bdcc |
| description | Malignant Melanoma is considered the most dangerous skin neoplasia for its potential to invade distant tissues and its associated mortality. Its incidence is considered epidemic. Mitotic rate was recently introduced in the AJCC guidelines as the 2nd most important prognostic factor for thin stage I melanomas, after tumoral thickness, as it strongly correlates with a lower survival rate. Together with ulceration, this variable changes the classification of thin tumors (≤1mm) from T1a to T1b, if at least one mitosis/ mm2 is present. This implies an alteration in patients’ management and treatment. It has been a target of discussion for its accuracy among clinicians and interobserver disparities. The cutoff of one mitosis as also been targeted, since mitotic figures can be found in benign lesions, particularly when immunohistochemistry is used. Mitotic rate has been used to refer patients to sentinel lymph node biopsy, which has also been a disagreement point. Immunohistochemistry in mitoses detection is still under investigation but it is proved to facilitate the observation, although having some objections. Standardization is essential to a more reliable method and adequate patient’s maneuver. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | masterThesis |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/48c52ffc-b8a3-4d86-9d6a-be54dd56ba10/download |
| id | ul_65debc90cd5cac2a6d7ea3f9d44fef67 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/29481 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/29481 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Marques, Sara Completo, 1992- |
| publishDate | 2016 |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engpt_PTMalignant Melanoma is considered the most dangerous skin neoplasia for its potential to invade distant tissues and its associated mortality. Its incidence is considered epidemic. Mitotic rate was recently introduced in the AJCC guidelines as the 2nd most important prognostic factor for thin stage I melanomas, after tumoral thickness, as it strongly correlates with a lower survival rate. Together with ulceration, this variable changes the classification of thin tumors (≤1mm) from T1a to T1b, if at least one mitosis/ mm2 is present. This implies an alteration in patients’ management and treatment. It has been a target of discussion for its accuracy among clinicians and interobserver disparities. The cutoff of one mitosis as also been targeted, since mitotic figures can be found in benign lesions, particularly when immunohistochemistry is used. Mitotic rate has been used to refer patients to sentinel lymph node biopsy, which has also been a disagreement point. Immunohistochemistry in mitoses detection is still under investigation but it is proved to facilitate the observation, although having some objections. Standardization is essential to a more reliable method and adequate patient’s maneuver.application/pdfpt_PTMitoses in cutaneous malignant melanomas : relevance in the prognosisMarques, Sara Completo, 1992-Almeida, Luís Soares deHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptURNurn:tid:2012885322017-10-30T15:28:06Z20162016-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/29481http://purl.org/coar/access_right/c_abf2open accessMelanócitoMelanomaMitoseÍndice mitóticoBiópsia de gânglio sentinelaImuno-histoquímica629607 bytesliteraturehttp://purl.org/coar/resource_type/c_bdccmaster thesishttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/48c52ffc-b8a3-4d86-9d6a-be54dd56ba10/download |
| spellingShingle | Mitoses in cutaneous malignant melanomas : relevance in the prognosis Mitoses in cutaneous malignant melanomas : relevance in the prognosis Marques, Sara Completo, 1992- Melanócito Melanoma Mitose Índice mitótico Biópsia de gânglio sentinela Imuno-histoquímica Marques, Sara Completo, 1992- Melanócito Melanoma Mitose Índice mitótico Biópsia de gânglio sentinela Imuno-histoquímica |
| status | SINGLETON |
| subject.fl_str_mv | Melanócito Melanoma Mitose Índice mitótico Biópsia de gânglio sentinela Imuno-histoquímica |
| title | Mitoses in cutaneous malignant melanomas : relevance in the prognosis |
| title_full | Mitoses in cutaneous malignant melanomas : relevance in the prognosis |
| title_fullStr | Mitoses in cutaneous malignant melanomas : relevance in the prognosis Mitoses in cutaneous malignant melanomas : relevance in the prognosis |
| title_full_unstemmed | Mitoses in cutaneous malignant melanomas : relevance in the prognosis Mitoses in cutaneous malignant melanomas : relevance in the prognosis |
| title_short | Mitoses in cutaneous malignant melanomas : relevance in the prognosis |
| title_sort | Mitoses in cutaneous malignant melanomas : relevance in the prognosis |
| topic | Melanócito Melanoma Mitose Índice mitótico Biópsia de gânglio sentinela Imuno-histoquímica |
| topic_facet | Melanócito Melanoma Mitose Índice mitótico Biópsia de gânglio sentinela Imuno-histoquímica |
| url | http://hdl.handle.net/10451/29481 |
| visible | 1 |