Publication
Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease
| Summary: | Inflammatory bowel diseases (IBD) are characterized by a chronic inflammatory process that affects the intestinal barrier structure. Recent evidence suggests that some food components can influence the integrity of the intestinal barrier and thus its permeability. We aimed at assessing the effect of food components on the intestinal permeability (IP) and on inflammatory markers in individuals with IBD by a single-blind randomized clinical study. Of the 53 individuals included, 47% (n = 25) had been diagnosed with IBD. The participants were divided into 4 groups. IBD patients were allocated to intervention group (n = 14) vs. no intervention group (n = 11), and the same happened with 28 control participants without disease (n = 14 in intervention group vs. n = 14 without intervention). Symptomatology, nutritional status, biochemical parameters (specifically serum zonulin (ZO) to measure IP) were evaluated on all individuals on an eight week period following a diet plan with/without potentially beneficial foods for the IP. At the beginning of the study, there were no significant differences in ZO values between individuals with and without IBD (p > 0.05). The effect of specific food components was inconclusive; however, a trend in the reduction of inflammatory parameters and on the prevalence of gastrointestinal symptomatology was observed. More controlled intervention studies with diet plans, including food components potentially beneficial for the integrity of the intestinal barrier, are of the utmost importance. |
|---|---|
| Main Authors: | Lacerda, Joana Franco |
| Other Authors: | Lagos, Ana Catarina; Carolino, Elisabete; Silva-Herdade, Ana S.; Silva, Manuel; Guerreiro, Catarina Sousa |
| Subject: | Inflammatory bowel disease Intestinal permeability Serum zonulin Inflammation Functional foods |
| Year: | 2021 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Universidade de Lisboa |
| Language: | English |
| Origin: | Repositório da Universidade de Lisboa |
| _version_ | 1866810386125160448 |
|---|---|
| author | Lacerda, Joana Franco |
| author2 | Lagos, Ana Catarina Carolino, Elisabete Silva-Herdade, Ana S. Silva, Manuel Guerreiro, Catarina Sousa |
| author2_role | author author author author author |
| author_facet | Lacerda, Joana Franco Lagos, Ana Catarina Carolino, Elisabete Silva-Herdade, Ana S. Silva, Manuel Guerreiro, Catarina Sousa |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Lacerda, Joana Franco\"},{\"Person.name\":\"Lagos, Ana Catarina\"},{\"Person.name\":\"Carolino, Elisabete\",\"Person.identifier.orcid\":\"0000-0003-4165-7052\"},{\"Person.name\":\"Silva-Herdade, Ana S.\",\"Person.identifier.orcid\":\"0000-0002-3023-1315\"},{\"Person.name\":\"Silva, Manuel\"},{\"Person.name\":\"Guerreiro, Catarina Sousa\",\"Person.identifier.orcid\":\"0000-0002-8730-6517\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Lacerda, Joana Franco Lagos, Ana Catarina Carolino, Elisabete Silva-Herdade, Ana S. Silva, Manuel Guerreiro, Catarina Sousa |
| datacite.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-03-23T16:18:48Z |
| datacite.date.embargoed.fl_str_mv | 2021-03-23T16:18:48Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Inflammatory bowel disease Intestinal permeability Serum zonulin Inflammation Functional foods |
| datacite.titles.title.fl_str_mv | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Lacerda, Joana Franco Lagos, Ana Catarina Carolino, Elisabete Silva-Herdade, Ana S. Silva, Manuel Guerreiro, Catarina Sousa |
| dc.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-03-23T16:18:48Z |
| dc.date.embargoed.fl_str_mv | 2021-03-23T16:18:48Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/46999 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Inflammatory bowel disease Intestinal permeability Serum zonulin Inflammation Functional foods |
| dc.title.fl_str_mv | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Inflammatory bowel diseases (IBD) are characterized by a chronic inflammatory process that affects the intestinal barrier structure. Recent evidence suggests that some food components can influence the integrity of the intestinal barrier and thus its permeability. We aimed at assessing the effect of food components on the intestinal permeability (IP) and on inflammatory markers in individuals with IBD by a single-blind randomized clinical study. Of the 53 individuals included, 47% (n = 25) had been diagnosed with IBD. The participants were divided into 4 groups. IBD patients were allocated to intervention group (n = 14) vs. no intervention group (n = 11), and the same happened with 28 control participants without disease (n = 14 in intervention group vs. n = 14 without intervention). Symptomatology, nutritional status, biochemical parameters (specifically serum zonulin (ZO) to measure IP) were evaluated on all individuals on an eight week period following a diet plan with/without potentially beneficial foods for the IP. At the beginning of the study, there were no significant differences in ZO values between individuals with and without IBD (p > 0.05). The effect of specific food components was inconclusive; however, a trend in the reduction of inflammatory parameters and on the prevalence of gastrointestinal symptomatology was observed. More controlled intervention studies with diet plans, including food components potentially beneficial for the integrity of the intestinal barrier, are of the utmost importance. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/f7e1e7db-6315-4f4a-bd18-b6c20ccc8074/download |
| id | ul_6c331ec973f81b1649946d55a5dfdfd2 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/46999 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/46999 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Lacerda, Joana Franco Lagos, Ana Catarina Carolino, Elisabete Carolino, Elisabete https://www.ciencia-id.pt/1216-EFA3-1E0F 1216-EFA3-1E0F http://orcid.org/0000-0003-4165-7052 0000-0003-4165-7052 Silva-Herdade, Ana S. Silva-Herdade, Ana S. https://www.ciencia-id.pt/6517-B340-F362 6517-B340-F362 http://orcid.org/0000-0002-3023-1315 0000-0002-3023-1315 Silva, Manuel Guerreiro, Catarina Sousa Guerreiro, Catarina Sousa https://www.ciencia-id.pt/311F-89E5-532C 311F-89E5-532C http://orcid.org/0000-0002-8730-6517 0000-0002-8730-6517 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engMDPIpt_PTInflammatory bowel diseases (IBD) are characterized by a chronic inflammatory process that affects the intestinal barrier structure. Recent evidence suggests that some food components can influence the integrity of the intestinal barrier and thus its permeability. We aimed at assessing the effect of food components on the intestinal permeability (IP) and on inflammatory markers in individuals with IBD by a single-blind randomized clinical study. Of the 53 individuals included, 47% (n = 25) had been diagnosed with IBD. The participants were divided into 4 groups. IBD patients were allocated to intervention group (n = 14) vs. no intervention group (n = 11), and the same happened with 28 control participants without disease (n = 14 in intervention group vs. n = 14 without intervention). Symptomatology, nutritional status, biochemical parameters (specifically serum zonulin (ZO) to measure IP) were evaluated on all individuals on an eight week period following a diet plan with/without potentially beneficial foods for the IP. At the beginning of the study, there were no significant differences in ZO values between individuals with and without IBD (p > 0.05). The effect of specific food components was inconclusive; however, a trend in the reduction of inflammatory parameters and on the prevalence of gastrointestinal symptomatology was observed. More controlled intervention studies with diet plans, including food components potentially beneficial for the integrity of the intestinal barrier, are of the utmost importance.application/pdfpt_PTFunctional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel diseaseLacerda, Joana FrancoLagos, Ana CatarinaPersonalCarolino, ElisabeteDSpacehttp://dspace.org/items/5580111f-6dde-4f18-98ca-514e225c9626DSpacehttp://dspace.org/items/5580111f-6dde-4f18-98ca-514e225c9626CarolinoElisabeteCiência IDhttps://www.ciencia-id.pt1216-EFA3-1E0FORCIDhttp://orcid.org0000-0003-4165-7052Researcher IDhttps://www.researcherid.comF-1012-2015Scopus Author IDhttps://www.scopus.com25821697000PersonalSilva-Herdade, Ana S.DSpacehttp://dspace.org/items/ad32fa9b-85eb-4679-a4c9-9f6109423b88DSpacehttp://dspace.org/items/ad32fa9b-85eb-4679-a4c9-9f6109423b88Silva-HerdadeAna S.Ciência IDhttps://www.ciencia-id.pt6517-B340-F362ORCIDhttp://orcid.org0000-0002-3023-1315Researcher IDhttps://www.researcherid.comB-2735-2019Silva, ManuelPersonalGuerreiro, Catarina SousaDSpacehttp://dspace.org/items/cd573b0e-731c-474b-b158-6d9cf011289bDSpacehttp://dspace.org/items/cd573b0e-731c-474b-b158-6d9cf011289bsousa guerreirocatarinaCiência IDhttps://www.ciencia-id.pt311F-89E5-532CORCIDhttp://orcid.org0000-0002-8730-6517HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptDOIIsPartOf10.3390/nu130206422021-03-23T16:18:48Z20212021-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/46999http://purl.org/coar/access_right/c_abf2open accessInflammatory bowel diseaseIntestinal permeabilitySerum zonulinInflammationFunctional foods777523 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2021http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/f7e1e7db-6315-4f4a-bd18-b6c20ccc8074/downloadNutrients132 |
| spellingShingle | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease Lacerda, Joana Franco Inflammatory bowel disease Intestinal permeability Serum zonulin Inflammation Functional foods |
| status | SINGLETON |
| subject.fl_str_mv | Inflammatory bowel disease Intestinal permeability Serum zonulin Inflammation Functional foods |
| title | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease |
| title_full | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease |
| title_fullStr | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease |
| title_full_unstemmed | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease |
| title_short | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease |
| title_sort | Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease |
| topic | Inflammatory bowel disease Intestinal permeability Serum zonulin Inflammation Functional foods |
| topic_facet | Inflammatory bowel disease Intestinal permeability Serum zonulin Inflammation Functional foods |
| url | http://hdl.handle.net/10451/46999 |
| visible | 1 |