Publicação
Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates
| Resumo: | Sex chromosomes are typically comprised of a non-recombining region and a recombining pseudoautosomal region. Accurately quantifying the relative size of these regions is critical for sex-chromosome biology both from a functional and evolutionary perspective. The evolution of the pseudoautosomal boundary (PAB) is well documented in haplorrhines (apes and monkeys) but not in strepsirrhines (lemurs and lorises). Here, we studied the PAB of seven species representing the main strepsirrhine lineages by sequencing a male and a female genome in each species and using sex differences in coverage to identify the PAB. We found that during primate evolution, the PAB has remained unchanged in strepsirrhines whereas several recombination suppression events moved the PAB and shortened the pseudoautosomal region in haplorrhines. Strepsirrhines are well known to have much lower sexual dimorphism than haplorrhines. We suggest that mutations with antagonistic effects between males and females have driven recombination suppression and PAB evolution in haplorrhines |
|---|---|
| Autores principais: | Shearn, Rylan |
| Outros Autores: | Wright, Alison; Mousset, Sylvain; Régis, Corinne; Penel, Simon; Lemaitre, Jean-François; Douay, Guillaume; Crouau-Roy, Brigitte; Lecompte, Emilie; Marais, Gabriel A.B. |
| Assunto: | primates |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866809900447825920 |
|---|---|
| author | Shearn, Rylan |
| author2 | Wright, Alison Mousset, Sylvain Régis, Corinne Penel, Simon Lemaitre, Jean-François Douay, Guillaume Crouau-Roy, Brigitte Lecompte, Emilie Marais, Gabriel A.B. |
| author2_role | author author author author author author author author author |
| author_facet | Shearn, Rylan Wright, Alison Mousset, Sylvain Régis, Corinne Penel, Simon Lemaitre, Jean-François Douay, Guillaume Crouau-Roy, Brigitte Lecompte, Emilie Marais, Gabriel A.B. |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Shearn, Rylan\"},{\"Person.name\":\"Wright, Alison\"},{\"Person.name\":\"Mousset, Sylvain\"},{\"Person.name\":\"Régis, Corinne\"},{\"Person.name\":\"Penel, Simon\"},{\"Person.name\":\"Lemaitre, Jean-François\"},{\"Person.name\":\"Douay, Guillaume\"},{\"Person.name\":\"Crouau-Roy, Brigitte\"},{\"Person.name\":\"Lecompte, Emilie\"},{\"Person.name\":\"Marais, Gabriel A.B.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Shearn, Rylan Wright, Alison Mousset, Sylvain Régis, Corinne Penel, Simon Lemaitre, Jean-François Douay, Guillaume Crouau-Roy, Brigitte Lecompte, Emilie Marais, Gabriel A.B. |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-09-21T15:26:35Z |
| datacite.date.embargoed.fl_str_mv | 2021-09-21T15:26:35Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | primates |
| datacite.titles.title.fl_str_mv | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Shearn, Rylan Wright, Alison Mousset, Sylvain Régis, Corinne Penel, Simon Lemaitre, Jean-François Douay, Guillaume Crouau-Roy, Brigitte Lecompte, Emilie Marais, Gabriel A.B. |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-09-21T15:26:35Z |
| dc.date.embargoed.fl_str_mv | 2021-09-21T15:26:35Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.5/21894 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | primates |
| dc.title.fl_str_mv | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Sex chromosomes are typically comprised of a non-recombining region and a recombining pseudoautosomal region. Accurately quantifying the relative size of these regions is critical for sex-chromosome biology both from a functional and evolutionary perspective. The evolution of the pseudoautosomal boundary (PAB) is well documented in haplorrhines (apes and monkeys) but not in strepsirrhines (lemurs and lorises). Here, we studied the PAB of seven species representing the main strepsirrhine lineages by sequencing a male and a female genome in each species and using sex differences in coverage to identify the PAB. We found that during primate evolution, the PAB has remained unchanged in strepsirrhines whereas several recombination suppression events moved the PAB and shortened the pseudoautosomal region in haplorrhines. Strepsirrhines are well known to have much lower sexual dimorphism than haplorrhines. We suggest that mutations with antagonistic effects between males and females have driven recombination suppression and PAB evolution in haplorrhines |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/dd9ceeb1-2ac3-4698-b0fb-fd283a4a8f46/download |
| id | ul_75fbcf3f59ac26caf67b00a64b9011fb |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.5/21894 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10400.5/21894 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Shearn, Rylan Wright, Alison Mousset, Sylvain Régis, Corinne Penel, Simon Lemaitre, Jean-François Douay, Guillaume Crouau-Roy, Brigitte Lecompte, Emilie Marais, Gabriel A.B. |
| publishDate | 2020 |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engpt_PTSex chromosomes are typically comprised of a non-recombining region and a recombining pseudoautosomal region. Accurately quantifying the relative size of these regions is critical for sex-chromosome biology both from a functional and evolutionary perspective. The evolution of the pseudoautosomal boundary (PAB) is well documented in haplorrhines (apes and monkeys) but not in strepsirrhines (lemurs and lorises). Here, we studied the PAB of seven species representing the main strepsirrhine lineages by sequencing a male and a female genome in each species and using sex differences in coverage to identify the PAB. We found that during primate evolution, the PAB has remained unchanged in strepsirrhines whereas several recombination suppression events moved the PAB and shortened the pseudoautosomal region in haplorrhines. Strepsirrhines are well known to have much lower sexual dimorphism than haplorrhines. We suggest that mutations with antagonistic effects between males and females have driven recombination suppression and PAB evolution in haplorrhinesapplication/pdfpt_PTEvolutionary stasis of the pseudoautosomal boundary in strepsirrhine primatesShearn, RylanWright, AlisonMousset, SylvainRégis, CorinnePenel, SimonLemaitre, Jean-FrançoisDouay, GuillaumeCrouau-Roy, BrigitteLecompte, EmilieMarais, Gabriel A.B.HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptDOIIsPartOfhttps://doi.org/10.7554/eLife.636502021-09-21T15:26:35Z20202020-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.5/21894http://purl.org/coar/access_right/c_abf2open accessprimates1926174 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/dd9ceeb1-2ac3-4698-b0fb-fd283a4a8f46/downloadeLife |
| spellingShingle | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates Shearn, Rylan primates |
| status | SINGLETON |
| subject.fl_str_mv | primates |
| title | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates |
| title_full | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates |
| title_fullStr | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates |
| title_full_unstemmed | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates |
| title_short | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates |
| title_sort | Evolutionary stasis of the pseudoautosomal boundary in strepsirrhine primates |
| topic | primates |
| topic_facet | primates |
| url | http://hdl.handle.net/10400.5/21894 |
| visible | 1 |