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International external validation of risk prediction model of 90-day mortality after gastrectomy for cancer using machine learning

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Resumo:Background: Radical gastrectomy remains the main treatment for gastric cancer, despite its high mortality. A clinical predictive model of 90-day mortality (90DM) risk after gastric cancer surgery based on the Spanish EURECCA registry database was developed using a matching learning algorithm. We performed an external validation of this model based on data from an international multicenter cohort of patients. Methods: A cohort of patients from the European GASTRODATA database was selected. Demographic, clinical, and treatment variables in the original and validation cohorts were compared. The performance of the model was evaluated using the area under the curve (AUC) for a random forest model. Results: The validation cohort included 2546 patients from 24 European hospitals. The advanced clinical T- and N-category, neoadjuvant therapy, open procedures, total gastrectomy rates, and mean volume of the centers were significantly higher in the validation cohort. The 90DM rate was also higher in the validation cohort (5.6%) vs. the original cohort (3.7%). The AUC in the validation model was 0.716. Conclusion: The externally validated model for predicting the 90DM risk in gastric cancer patients undergoing gastrectomy with curative intent continues to be as useful as the original model in clinical practice.
Autores principais:Dal Cero, Mariagiulia
Outros Autores:Gibert, Joan; Grande, Luis; Gimeno, Marta; Osorio, Javier; Bencivenga, Maria; Fumagalli Romario, Uberto; Rosati, Riccardo; Morgagni, Paolo; Gisbertz, Suzanne; Polkowski, Wojciech P.; Lara Santos, Lucio; Kołodziejczyk, Piotr; Kielan, Wojciech; Reddavid, Rossella; van Sandick, Johanna W.; Baiocchi, Gian Luca; Gockel, Ines; Davies, Andrew; Wijnhoven, Bas P. L.; Reim, Daniel; Costa, Paulo M.; Allum, William H.; Piessen, Guillaume; Reynolds, John V.; Mönig, Stefan P.; Schneider, Paul M.; Garsot, Elisenda; Eizaguirre, Emma; Miró, Mònica; Castro, Sandra; Miranda, Coro; Monzonis-Hernández, Xavier; Pera, Manuel
Assunto:Gastrectomy Gastric cancer Machine learning Mortality Prediction Validation
Ano:2024
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa

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