Publicação
Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects
| Resumo: | Background: The hepatitis C virus (HCV) is known to infect the brain, however, the findings based on associated neuropsychiatric syndrome are controversial and the association itself remains unclear. Gender research in HCV infection is limited, failing to integrate the role of gender differences in neurocognitive syndrome. The aim of this study was to characterize psychological and neurocognitive profiles in HCV-infected patients before treatment and to explore gender differences in those profiles, as well as the impact of disease severity. Methods: A total of 86 patients diagnosed with chronic hepatitis C were included. Depression and anxiety were assessed using Hamilton anxiety scale (HAM-A), Hamilton depression scale (HAM-D), Beck Depression Inventory (BDI). For cognition, a neuropsychological battery to measure attention, concentration and memory was used, and executive function components validated for the Portuguese population was also used before starting treatment. To identify the disease severity, platelet ratio index, and FibroScan® were used. Results: A statistically significant gender effect was found on HAM-A (B = 0.64, CI: 0.17–1.11) and HAM-D (B = 0.62, CI: 0.14–1.09), with women scoring higher compared to men. Regarding neuropsychological scores, significant differences between gender were identified in executive functions measured by Trail Making Test (TMT B) (B = 0.48, CI: 0.02–0.97), TMT B-A (B = 0.26, CI: −39.2 to −3.7) and in digit span total (B = −0.52, CI: −1.0 to −0.04), with women performing worse than men. Controlling for years of substance dependence, TMT-B and TMT B-A showed significant gender differences. Regarding the presence or absence of substance dependence, only HAM-A and HAM-D remained significant. For categorical variables, Digit Span Total was also influenced by gender, with women being more likely to be impaired: odds ratio (OR) = 7.07, CI: 2.04–24.45), and a trend was observed for Digit Span Backward (OR = 3.57, CI: 1.31–9.75). No significant differences were found between disease severity and neurocognitive performance. Conclusion: Data suggest that gender has an influence on depression, anxiety and cognitive functions with women showing greater impairment compared with men. This effect seems to be influenced by substance dependence. |
|---|---|
| Autores principais: | Pires Barreira, David |
| Outros Autores: | Marinho, Rui; Bicho, Manuel; Flores, Isabel; Fialho, Renata; Ouakinin, Sílvia |
| Assunto: | Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866810140941877248 |
|---|---|
| author | Pires Barreira, David |
| author2 | Marinho, Rui Bicho, Manuel Flores, Isabel Fialho, Renata Ouakinin, Sílvia |
| author2_role | author author author author author |
| author_facet | Pires Barreira, David Marinho, Rui Bicho, Manuel Flores, Isabel Fialho, Renata Ouakinin, Sílvia |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pires Barreira, David\",\"Person.identifier.orcid\":\"0000-0001-7273-8547\"},{\"Person.name\":\"Marinho, Rui\",\"Person.identifier.orcid\":\"0000-0003-1327-3537\"},{\"Person.name\":\"Bicho, Manuel\",\"Person.identifier.orcid\":\"0000-0002-5773-5687\"},{\"Person.name\":\"Flores, Isabel\"},{\"Person.name\":\"Fialho, Renata\"},{\"Person.name\":\"Ouakinin, Sílvia\",\"Person.identifier.orcid\":\"0000-0002-2123-9104\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Pires Barreira, David Marinho, Rui Bicho, Manuel Flores, Isabel Fialho, Renata Ouakinin, Sílvia |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2019-11-05T16:05:53Z |
| datacite.date.embargoed.fl_str_mv | 2019-11-05T16:05:53Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
| datacite.titles.title.fl_str_mv | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Pires Barreira, David Marinho, Rui Bicho, Manuel Flores, Isabel Fialho, Renata Ouakinin, Sílvia |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2019-11-05T16:05:53Z |
| dc.date.embargoed.fl_str_mv | 2019-11-05T16:05:53Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/40079 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Frontiers Media |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
| dc.title.fl_str_mv | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: The hepatitis C virus (HCV) is known to infect the brain, however, the findings based on associated neuropsychiatric syndrome are controversial and the association itself remains unclear. Gender research in HCV infection is limited, failing to integrate the role of gender differences in neurocognitive syndrome. The aim of this study was to characterize psychological and neurocognitive profiles in HCV-infected patients before treatment and to explore gender differences in those profiles, as well as the impact of disease severity. Methods: A total of 86 patients diagnosed with chronic hepatitis C were included. Depression and anxiety were assessed using Hamilton anxiety scale (HAM-A), Hamilton depression scale (HAM-D), Beck Depression Inventory (BDI). For cognition, a neuropsychological battery to measure attention, concentration and memory was used, and executive function components validated for the Portuguese population was also used before starting treatment. To identify the disease severity, platelet ratio index, and FibroScan® were used. Results: A statistically significant gender effect was found on HAM-A (B = 0.64, CI: 0.17–1.11) and HAM-D (B = 0.62, CI: 0.14–1.09), with women scoring higher compared to men. Regarding neuropsychological scores, significant differences between gender were identified in executive functions measured by Trail Making Test (TMT B) (B = 0.48, CI: 0.02–0.97), TMT B-A (B = 0.26, CI: −39.2 to −3.7) and in digit span total (B = −0.52, CI: −1.0 to −0.04), with women performing worse than men. Controlling for years of substance dependence, TMT-B and TMT B-A showed significant gender differences. Regarding the presence or absence of substance dependence, only HAM-A and HAM-D remained significant. For categorical variables, Digit Span Total was also influenced by gender, with women being more likely to be impaired: odds ratio (OR) = 7.07, CI: 2.04–24.45), and a trend was observed for Digit Span Backward (OR = 3.57, CI: 1.31–9.75). No significant differences were found between disease severity and neurocognitive performance. Conclusion: Data suggest that gender has an influence on depression, anxiety and cognitive functions with women showing greater impairment compared with men. This effect seems to be influenced by substance dependence. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/1aacfddb-4902-4b2e-8a04-b3a9b02daf2a/download |
| id | ul_7c41e7f94bf2d1d23b3e37580f85e4e6 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/40079 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/40079 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Pires Barreira, David Pires Barreira, David https://www.ciencia-id.pt/931F-B799-E0F2 931F-B799-E0F2 http://orcid.org/0000-0001-7273-8547 0000-0001-7273-8547 Marinho, Rui Marinho, Rui https://www.ciencia-id.pt/531A-BB6A-AA45 531A-BB6A-AA45 http://orcid.org/0000-0003-1327-3537 0000-0003-1327-3537 Bicho, Manuel Bicho, Manuel https://www.ciencia-id.pt/9512-8D22-1B28 9512-8D22-1B28 http://orcid.org/0000-0002-5773-5687 0000-0002-5773-5687 Flores, Isabel Fialho, Renata Ouakinin, Sílvia Ouakinin, Sílvia http://orcid.org/0000-0002-2123-9104 0000-0002-2123-9104 |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Frontiers Media |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engFrontiers Mediapt_PTBackground: The hepatitis C virus (HCV) is known to infect the brain, however, the findings based on associated neuropsychiatric syndrome are controversial and the association itself remains unclear. Gender research in HCV infection is limited, failing to integrate the role of gender differences in neurocognitive syndrome. The aim of this study was to characterize psychological and neurocognitive profiles in HCV-infected patients before treatment and to explore gender differences in those profiles, as well as the impact of disease severity. Methods: A total of 86 patients diagnosed with chronic hepatitis C were included. Depression and anxiety were assessed using Hamilton anxiety scale (HAM-A), Hamilton depression scale (HAM-D), Beck Depression Inventory (BDI). For cognition, a neuropsychological battery to measure attention, concentration and memory was used, and executive function components validated for the Portuguese population was also used before starting treatment. To identify the disease severity, platelet ratio index, and FibroScan® were used. Results: A statistically significant gender effect was found on HAM-A (B = 0.64, CI: 0.17–1.11) and HAM-D (B = 0.62, CI: 0.14–1.09), with women scoring higher compared to men. Regarding neuropsychological scores, significant differences between gender were identified in executive functions measured by Trail Making Test (TMT B) (B = 0.48, CI: 0.02–0.97), TMT B-A (B = 0.26, CI: −39.2 to −3.7) and in digit span total (B = −0.52, CI: −1.0 to −0.04), with women performing worse than men. Controlling for years of substance dependence, TMT-B and TMT B-A showed significant gender differences. Regarding the presence or absence of substance dependence, only HAM-A and HAM-D remained significant. For categorical variables, Digit Span Total was also influenced by gender, with women being more likely to be impaired: odds ratio (OR) = 7.07, CI: 2.04–24.45), and a trend was observed for Digit Span Backward (OR = 3.57, CI: 1.31–9.75). No significant differences were found between disease severity and neurocognitive performance. Conclusion: Data suggest that gender has an influence on depression, anxiety and cognitive functions with women showing greater impairment compared with men. This effect seems to be influenced by substance dependence.application/pdfpt_PTHepatitis C pretreatment profile and gender differences : cognition and disease severity effectsPersonalPires Barreira, DavidDSpacehttp://dspace.org/items/6b576d91-1f3b-4e5f-a8a9-235556906cb6DSpacehttp://dspace.org/items/6b576d91-1f3b-4e5f-a8a9-235556906cb6Pires BarreiraDavidCiência IDhttps://www.ciencia-id.pt931F-B799-E0F2ORCIDhttp://orcid.org0000-0001-7273-8547Scopus Author IDhttps://www.scopus.com55915259900Scopus Author IDhttps://www.scopus.com0000-0001-7273-8547Scopus Author IDhttps://www.scopus.com55915259900PersonalMarinho, RuiDSpacehttp://dspace.org/items/b842b032-ae00-453c-b774-b84ec4a09199DSpacehttp://dspace.org/items/b842b032-ae00-453c-b774-b84ec4a09199MarinhoRuiCiência IDhttps://www.ciencia-id.pt531A-BB6A-AA45ORCIDhttp://orcid.org0000-0003-1327-3537Scopus Author IDhttps://www.scopus.com7005027284PersonalBicho, ManuelDSpacehttp://dspace.org/items/c61e4f7e-28b3-47b4-bc5d-677b73fc3aecDSpacehttp://dspace.org/items/c61e4f7e-28b3-47b4-bc5d-677b73fc3aecBichoManuelCiência IDhttps://www.ciencia-id.pt9512-8D22-1B28ORCIDhttp://orcid.org0000-0002-5773-5687Scopus Author IDhttps://www.scopus.com7004153755Flores, IsabelFialho, RenataPersonalOuakinin, SílviaDSpacehttp://dspace.org/items/c98fc35c-587b-4d47-a4af-180c3dfed235DSpacehttp://dspace.org/items/c98fc35c-587b-4d47-a4af-180c3dfed235OuakininSílviaORCIDhttp://orcid.org0000-0002-2123-9104Scopus Author IDhttps://www.scopus.com24339026700HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf1664-1078DOIIsPartOf10.3389/fpsyg.2019.023172019-11-05T16:05:53Z20192019-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/40079http://purl.org/coar/access_right/c_abf2open accessHepatitis CNeurocognitionAnxietyDepressionGenderDisease severity275076 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2019http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/1aacfddb-4902-4b2e-8a04-b3a9b02daf2a/downloadFrontiers in Psychology102317 |
| spellingShingle | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects Pires Barreira, David Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
| status | SINGLETON |
| subject.fl_str_mv | Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
| title | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
| title_full | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
| title_fullStr | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
| title_full_unstemmed | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
| title_short | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
| title_sort | Hepatitis C pretreatment profile and gender differences : cognition and disease severity effects |
| topic | Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
| topic_facet | Hepatitis C Neurocognition Anxiety Depression Gender Disease severity |
| url | http://hdl.handle.net/10451/40079 |
| visible | 1 |