Publicação
Manganese transport into the brain
| Resumo: | An important process in the toxicologic outcome of exposure to metals is their transport from plasma into the brain across the capillary endothelial cells that comprise the blood-brain barrier (BBB). The review, briefly delineates the known transport mechanisms of manganese (Mn) across the BBB, a crucial step in Mn accumulation in the brain. Herein, we discuss the distribution of Mn in the central nervous system (CNS) and identify putative transport mechanism for Mn, emphasize the close chemical interaction between Mn and iron (Fe) and the role of transferrin (Tf) and divalent metal transport1 (DMT1) in this process. |
|---|---|
| Autores principais: | Aschner, Michael |
| Outros Autores: | dos Santos, Ana Paula Marreilha; Erikson, Keith M.; Zheng, Wei |
| Assunto: | Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear |
| Ano: | 2008 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso a metadados |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866811556837195776 |
|---|---|
| author | Aschner, Michael |
| author2 | dos Santos, Ana Paula Marreilha Erikson, Keith M. Zheng, Wei |
| author2_role | author author author |
| author_facet | Aschner, Michael dos Santos, Ana Paula Marreilha Erikson, Keith M. Zheng, Wei |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Aschner, Michael\"},{\"Person.name\":\"dos Santos, Ana Paula Marreilha\"},{\"Person.name\":\"Erikson, Keith M.\"},{\"Person.name\":\"Zheng, Wei\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Aschner, Michael dos Santos, Ana Paula Marreilha Erikson, Keith M. Zheng, Wei |
| datacite.date.Accepted.fl_str_mv | 2008-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-12-30T10:17:11Z |
| datacite.date.embargoed.fl_str_mv | 2015-12-30T10:17:11Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_14cb |
| datacite.subjects.subject.fl_str_mv | Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear |
| datacite.titles.title.fl_str_mv | Manganese transport into the brain putative mechanisms |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Aschner, Michael dos Santos, Ana Paula Marreilha Erikson, Keith M. Zheng, Wei |
| dc.date.Accepted.fl_str_mv | 2008-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-12-30T10:17:11Z |
| dc.date.embargoed.fl_str_mv | 2015-12-30T10:17:11Z |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/20954 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MONTROUGE |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_14cb |
| dc.subject.none.fl_str_mv | Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear |
| dc.title.fl_str_mv | Manganese transport into the brain putative mechanisms |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | An important process in the toxicologic outcome of exposure to metals is their transport from plasma into the brain across the capillary endothelial cells that comprise the blood-brain barrier (BBB). The review, briefly delineates the known transport mechanisms of manganese (Mn) across the BBB, a crucial step in Mn accumulation in the brain. Herein, we discuss the distribution of Mn in the central nervous system (CNS) and identify putative transport mechanism for Mn, emphasize the close chemical interaction between Mn and iron (Fe) and the role of transferrin (Tf) and divalent metal transport1 (DMT1) in this process. |
| dirty | 0 |
| eu_rights_str_mv | metadataOnlyAccess |
| format | article |
| id | ul_7ca69522c0200bbcc677ea5802b07d8a |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/20954 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/20954 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Aschner, Michael dos Santos, Ana Paula Marreilha Erikson, Keith M. Zheng, Wei |
| publishDate | 2008 |
| publisher.none.fl_str_mv | MONTROUGE |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engMONTROUGEAn important process in the toxicologic outcome of exposure to metals is their transport from plasma into the brain across the capillary endothelial cells that comprise the blood-brain barrier (BBB). The review, briefly delineates the known transport mechanisms of manganese (Mn) across the BBB, a crucial step in Mn accumulation in the brain. Herein, we discuss the distribution of Mn in the central nervous system (CNS) and identify putative transport mechanism for Mn, emphasize the close chemical interaction between Mn and iron (Fe) and the role of transferrin (Tf) and divalent metal transport1 (DMT1) in this process.Manganese transport into the brainputative mechanismsAschner, Michaeldos Santos, Ana Paula MarreilhaErikson, Keith M.Zheng, WeiHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISBNIsPartOf978-2-7420-0714-12015-12-30T10:17:11Z20082008-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/20954http://purl.org/coar/access_right/c_14cbmetadata only accessBiochemistry & Molecular BiologyChemistry, Inorganic & Nuclearliteraturehttp://purl.org/coar/resource_type/c_6501journal article695700 |
| spellingShingle | Manganese transport into the brain Aschner, Michael Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear |
| status | SINGLETON |
| subject.fl_str_mv | Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear |
| title | Manganese transport into the brain |
| title_full | Manganese transport into the brain |
| title_fullStr | Manganese transport into the brain |
| title_full_unstemmed | Manganese transport into the brain |
| title_short | Manganese transport into the brain |
| title_sort | Manganese transport into the brain |
| topic | Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear |
| topic_facet | Biochemistry & Molecular Biology Chemistry, Inorganic & Nuclear |
| url | http://hdl.handle.net/10451/20954 |
| visible | 1 |