Publicação
The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment
| Resumo: | Breast cancer is a high-burden malignancy for society, whose impact boosts a continuous search for novel diagnostic and therapeutic tools. Among the recent therapeutic approaches, photothermal therapy (PTT), which causes tumor cell death by hyperthermia after being irradiated with a light source, represents a high-potential strategy. Furthermore, the effectiveness of PTT can be improved by combining near infrared (NIR) irradiation with gold nanoparticles (AuNPs) as photothermal enhancers. Herein, an alternative synthetic method using rosmarinic acid (RA) for synthesizing AuNPs is reported. The RA concentration was varied and its impact on the AuNPs physicochemical and optical features was assessed. Results showed that RA concentration plays an active role on AuNPs features, allowing the optimization of mean size and maximum absorbance peak. Moreover, the synthetic method explored here allowed us to obtain negatively charged AuNPs with sizes favoring the local particle accumulation at tumor site and maximum absorbance peaks within the NIR region. In addition, AuNPs were safe both in vitro and in vivo. In conclusion, the synthesized AuNPs present favorable properties to be applied as part of a PTT system combining AuNPs with a NIR laser for the treatment of breast cancer. |
|---|---|
| Autores principais: | Ferreira-Gonçalves, Tânia |
| Outros Autores: | Gaspar, Maria Manuela; Coelho, João M. P.; Marques, Vanda; Viana, Ana S.; Ascensão, Lia; Carvalho, Lina; Rodrigues, Cecília M. P.; Ferreira, Hugo Alexandre; Alves Ferreira, David; Reis, Catarina Pinto |
| Assunto: | Rosmarinic acid Gold nanoparticles Photothermal therapy Breast cancer treatment |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866811259826995200 |
|---|---|
| author | Ferreira-Gonçalves, Tânia |
| author2 | Gaspar, Maria Manuela Coelho, João M. P. Marques, Vanda Viana, Ana S. Ascensão, Lia Carvalho, Lina Rodrigues, Cecília M. P. Ferreira, Hugo Alexandre Alves Ferreira, David Reis, Catarina Pinto |
| author2_role | author author author author author author author author author author |
| author_facet | Ferreira-Gonçalves, Tânia Gaspar, Maria Manuela Coelho, João M. P. Marques, Vanda Viana, Ana S. Ascensão, Lia Carvalho, Lina Rodrigues, Cecília M. P. Ferreira, Hugo Alexandre Alves Ferreira, David Reis, Catarina Pinto |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
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| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Ferreira-Gonçalves, Tânia Gaspar, Maria Manuela Coelho, João M. P. Marques, Vanda Viana, Ana S. Ascensão, Lia Carvalho, Lina Rodrigues, Cecília M. P. Ferreira, Hugo Alexandre Alves Ferreira, David Reis, Catarina Pinto |
| datacite.date.Accepted.fl_str_mv | 2022-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-02-22T13:11:26Z |
| datacite.date.embargoed.fl_str_mv | 2022-02-22T13:11:26Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Rosmarinic acid Gold nanoparticles Photothermal therapy Breast cancer treatment |
| datacite.titles.title.fl_str_mv | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Ferreira-Gonçalves, Tânia Gaspar, Maria Manuela Coelho, João M. P. Marques, Vanda Viana, Ana S. Ascensão, Lia Carvalho, Lina Rodrigues, Cecília M. P. Ferreira, Hugo Alexandre Alves Ferreira, David Reis, Catarina Pinto |
| dc.date.Accepted.fl_str_mv | 2022-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-02-22T13:11:26Z |
| dc.date.embargoed.fl_str_mv | 2022-02-22T13:11:26Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/51446 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI [Commercial Publisher] |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Rosmarinic acid Gold nanoparticles Photothermal therapy Breast cancer treatment |
| dc.title.fl_str_mv | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Breast cancer is a high-burden malignancy for society, whose impact boosts a continuous search for novel diagnostic and therapeutic tools. Among the recent therapeutic approaches, photothermal therapy (PTT), which causes tumor cell death by hyperthermia after being irradiated with a light source, represents a high-potential strategy. Furthermore, the effectiveness of PTT can be improved by combining near infrared (NIR) irradiation with gold nanoparticles (AuNPs) as photothermal enhancers. Herein, an alternative synthetic method using rosmarinic acid (RA) for synthesizing AuNPs is reported. The RA concentration was varied and its impact on the AuNPs physicochemical and optical features was assessed. Results showed that RA concentration plays an active role on AuNPs features, allowing the optimization of mean size and maximum absorbance peak. Moreover, the synthetic method explored here allowed us to obtain negatively charged AuNPs with sizes favoring the local particle accumulation at tumor site and maximum absorbance peaks within the NIR region. In addition, AuNPs were safe both in vitro and in vivo. In conclusion, the synthesized AuNPs present favorable properties to be applied as part of a PTT system combining AuNPs with a NIR laser for the treatment of breast cancer. |
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| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/e2767560-96ff-4eab-bc6f-805d5fdc10b9/download |
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| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID 6817 - DCRRNI ID OE |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10451/51446 |
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| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
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| person_str_mv | Ferreira-Gonçalves, Tânia Ferreira-Gonçalves, Tânia https://www.ciencia-id.pt/2914-A05C-F762 2914-A05C-F762 http://orcid.org/0000-0001-9916-3907 0000-0001-9916-3907 Gaspar, Maria Manuela Gaspar, Maria Manuela https://www.ciencia-id.pt/3A10-0732-13F5 3A10-0732-13F5 http://orcid.org/0000-0001-6814-7226 0000-0001-6814-7226 Coelho, João M. P. Coelho, João M. P. https://www.ciencia-id.pt/401F-637C-DD7A 401F-637C-DD7A http://orcid.org/0000-0002-4339-0550 0000-0002-4339-0550 Marques, Vanda Marques, Vanda https://www.ciencia-id.pt/4716-E0F9-1EC7 4716-E0F9-1EC7 http://orcid.org/0000-0003-3515-0781 0000-0003-3515-0781 Viana, Ana S. Viana, Ana S. http://orcid.org/0000-0001-8405-9672 0000-0001-8405-9672 Ascensão, Lia Ascensão, Lia https://www.ciencia-id.pt/3714-4001-DCD6 3714-4001-DCD6 http://orcid.org/0000-0001-7439-5912 0000-0001-7439-5912 Carvalho, Lina Carvalho, Lina http://orcid.org/0000-0003-0569-0269 0000-0003-0569-0269 Rodrigues, Cecília M. P. Rodrigues, Cecília M. P. https://www.ciencia-id.pt/DC18-39A7-F287 DC18-39A7-F287 http://orcid.org/0000-0002-4829-754X 0000-0002-4829-754X Ferreira, Hugo Alexandre Alves Ferreira, David Alves Ferreira, David https://www.ciencia-id.pt/1818-3F02-AD77 1818-3F02-AD77 http://orcid.org/0000-0002-9720-3140 0000-0002-9720-3140 Reis, Catarina Pinto Reis, Catarina Pinto https://www.ciencia-id.pt/1317-A7D6-3B1C 1317-A7D6-3B1C http://orcid.org/0000-0002-1046-4031 0000-0002-1046-4031 |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI [Commercial Publisher] |
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| spelling | engMDPI [Commercial Publisher]pt_PTBreast cancer is a high-burden malignancy for society, whose impact boosts a continuous search for novel diagnostic and therapeutic tools. Among the recent therapeutic approaches, photothermal therapy (PTT), which causes tumor cell death by hyperthermia after being irradiated with a light source, represents a high-potential strategy. Furthermore, the effectiveness of PTT can be improved by combining near infrared (NIR) irradiation with gold nanoparticles (AuNPs) as photothermal enhancers. Herein, an alternative synthetic method using rosmarinic acid (RA) for synthesizing AuNPs is reported. The RA concentration was varied and its impact on the AuNPs physicochemical and optical features was assessed. Results showed that RA concentration plays an active role on AuNPs features, allowing the optimization of mean size and maximum absorbance peak. Moreover, the synthetic method explored here allowed us to obtain negatively charged AuNPs with sizes favoring the local particle accumulation at tumor site and maximum absorbance peaks within the NIR region. In addition, AuNPs were safe both in vitro and in vivo. In conclusion, the synthesized AuNPs present favorable properties to be applied as part of a PTT system combining AuNPs with a NIR laser for the treatment of breast cancer.application/pdfpt_PTThe Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer TreatmentPersonalFerreira-Gonçalves, TâniaDSpacehttp://dspace.org/items/f65c6fd6-44d0-44ed-9161-371024a59271DSpacehttp://dspace.org/items/f65c6fd6-44d0-44ed-9161-371024a59271GonçalvesTâniaCiência IDhttps://www.ciencia-id.pt2914-A05C-F762ORCIDhttp://orcid.org0000-0001-9916-3907Scopus Author IDhttps://www.scopus.com57218871355PersonalGaspar, Maria ManuelaDSpacehttp://dspace.org/items/9e3a2d04-322f-4f0f-877c-45481624aa05DSpacehttp://dspace.org/items/9e3a2d04-322f-4f0f-877c-45481624aa05de Jesus Guilherme GasparMaria ManuelaCiência IDhttps://www.ciencia-id.pt3A10-0732-13F5ORCIDhttp://orcid.org0000-0001-6814-7226Scopus Author IDhttps://www.scopus.com15834627800PersonalCoelho, João M. 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| spellingShingle | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment Ferreira-Gonçalves, Tânia Rosmarinic acid Gold nanoparticles Photothermal therapy Breast cancer treatment |
| status | SINGLETON |
| subject.fl_str_mv | Rosmarinic acid Gold nanoparticles Photothermal therapy Breast cancer treatment |
| title | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment |
| title_full | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment |
| title_fullStr | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment |
| title_full_unstemmed | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment |
| title_short | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment |
| title_sort | The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment |
| topic | Rosmarinic acid Gold nanoparticles Photothermal therapy Breast cancer treatment |
| topic_facet | Rosmarinic acid Gold nanoparticles Photothermal therapy Breast cancer treatment |
| url | http://hdl.handle.net/10451/51446 |
| visible | 1 |