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Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling

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Resumo:Resting state (RS) brain activity is inherently non-stationary. Hidden Semi-Markov Models (HsMM) can characterize the continuous RS data as a sequence of recurring and distinct brain states along with their spatio-temporal dynamics. Recent explorations suggest that EEG brain state dynamics in the alpha frequency link to auditory hallucination proneness (HP) in nonclinical individuals. The present study aims to replicate these findings to elucidate robust neural correlates of hallucinatory vulnerability. Specifically, we aimed to investigate the reproducibility of HsMM states across different data sets and within-data set variants as well as the replicability of the association between alpha brain state dynamics and HP. We found that most brain states are reproducible in different data sets, confirming that the HsMM characterized robust and generalizable EEG RS dynamics. Brain state topographies and temporal dynamics of different within-data set variants showed substantial similarities and were robust against reduced data length and number of electrodes. However, the association with HP was not directly reproducible across data sets. These results indicate that the sensitivity of brain state dynamics to capture individual variability in HP may depend on the data recording characteristics and individual variability in RS cognition, such as mind wandering. We suggest that the order in which eyes-open and eyes-closed RS data are acquired directly influences an individual’s attentional state and generation of spontaneous thoughts, and thereby might mediate the link to hallucinatory vulnerability.
Autores principais:Honcamp, Hanna
Outros Autores:Schwartze, Michael; Amorim, Maria; Linden, David; Pinheiro, Ana P.; Kotz, Sonja
Assunto:Hidden Semi-Markov Model Resting state Alpha dynamics Reproducibility Hallucination proneness Spontaneous thoughts
Ano:2023
País:Portugal
Tipo de documento:preprint
Tipo de acesso:acesso aberto
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa
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author Honcamp, Hanna
author2 Schwartze, Michael
Amorim, Maria
Linden, David
Pinheiro, Ana P.
Kotz, Sonja
author2_role author
author
author
author
author
author_facet Honcamp, Hanna
Schwartze, Michael
Amorim, Maria
Linden, David
Pinheiro, Ana P.
Kotz, Sonja
author_role author
contributor_name_str_mv Repositório Científico de Acesso Aberto da ULisboa
country_str PT
creators_json_txt [{\"Person.name\":\"Honcamp, Hanna\",\"Person.identifier.orcid\":\"0009-0001-3373-9368\"},{\"Person.name\":\"Schwartze, Michael\",\"Person.identifier.orcid\":\"0000-0003-3366-4893\"},{\"Person.name\":\"Amorim, Maria\",\"Person.identifier.orcid\":\"0000-0002-9279-0921\"},{\"Person.name\":\"Linden, David\",\"Person.identifier.orcid\":\"0000-0002-5638-9292\"},{\"Person.name\":\"Pinheiro, Ana P.\",\"Person.identifier.orcid\":\"0000-0002-7981-3682\"},{\"Person.name\":\"Kotz, Sonja\",\"Person.identifier.orcid\":\"0000-0002-5894-4624\"}]
datacite.contributors.contributor.contributorName.fl_str_mv Repositório Científico de Acesso Aberto da ULisboa
datacite.creators.creator.creatorName.fl_str_mv Honcamp, Hanna
Schwartze, Michael
Amorim, Maria
Linden, David
Pinheiro, Ana P.
Kotz, Sonja
datacite.date.Accepted.fl_str_mv 2023-12-12T00:00:00Z
datacite.date.available.fl_str_mv 2024-02-22T16:54:59Z
datacite.date.embargoed.fl_str_mv 2024-02-22T16:54:59Z
datacite.rights.fl_str_mv http://purl.org/coar/access_right/c_abf2
datacite.subjects.subject.fl_str_mv Hidden Semi-Markov Model
Resting state
Alpha dynamics
Reproducibility
Hallucination proneness
Spontaneous thoughts
datacite.titles.title.fl_str_mv Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
dc.contributor.none.fl_str_mv Repositório Científico de Acesso Aberto da ULisboa
dc.creator.none.fl_str_mv Honcamp, Hanna
Schwartze, Michael
Amorim, Maria
Linden, David
Pinheiro, Ana P.
Kotz, Sonja
dc.date.Accepted.fl_str_mv 2023-12-12T00:00:00Z
dc.date.available.fl_str_mv 2024-02-22T16:54:59Z
dc.date.embargoed.fl_str_mv 2024-02-22T16:54:59Z
dc.format.none.fl_str_mv application/pdf
dc.identifier.none.fl_str_mv http://hdl.handle.net/10451/62851
dc.language.none.fl_str_mv eng
dc.rights.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.subject.none.fl_str_mv Hidden Semi-Markov Model
Resting state
Alpha dynamics
Reproducibility
Hallucination proneness
Spontaneous thoughts
dc.title.fl_str_mv Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
dc.type.none.fl_str_mv http://purl.org/coar/resource_type/c_816b
description Resting state (RS) brain activity is inherently non-stationary. Hidden Semi-Markov Models (HsMM) can characterize the continuous RS data as a sequence of recurring and distinct brain states along with their spatio-temporal dynamics. Recent explorations suggest that EEG brain state dynamics in the alpha frequency link to auditory hallucination proneness (HP) in nonclinical individuals. The present study aims to replicate these findings to elucidate robust neural correlates of hallucinatory vulnerability. Specifically, we aimed to investigate the reproducibility of HsMM states across different data sets and within-data set variants as well as the replicability of the association between alpha brain state dynamics and HP. We found that most brain states are reproducible in different data sets, confirming that the HsMM characterized robust and generalizable EEG RS dynamics. Brain state topographies and temporal dynamics of different within-data set variants showed substantial similarities and were robust against reduced data length and number of electrodes. However, the association with HP was not directly reproducible across data sets. These results indicate that the sensitivity of brain state dynamics to capture individual variability in HP may depend on the data recording characteristics and individual variability in RS cognition, such as mind wandering. We suggest that the order in which eyes-open and eyes-closed RS data are acquired directly influences an individual’s attentional state and generation of spontaneous thoughts, and thereby might mediate the link to hallucinatory vulnerability.
dirty 0
eu_rights_str_mv openAccess
format preprint
fulltext.url.fl_str_mv https://repositorio.ulisboa.pt/bitstreams/ce5899f4-eb90-4b3b-bee6-4912a6bff02a/download
id ul_8d2d131c4fb24ccf76bd1e034d3be56e
identifier.url.fl_str_mv http://hdl.handle.net/10451/62851
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institution Universidade de Lisboa
instname_str Universidade de Lisboa
language eng
network_acronym_str ul
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oai_identifier_str oai:repositorio.ulisboa.pt:10451/62851
organization_str_mv urn:organizationAcronym:ul
person_str_mv Honcamp, Hanna
Honcamp, Hanna
http://orcid.org/0009-0001-3373-9368
0009-0001-3373-9368
Schwartze, Michael
Schwartze, Michael
https://www.ciencia-id.pt/1515-F9DE-0BA3
1515-F9DE-0BA3
http://orcid.org/0000-0003-3366-4893
0000-0003-3366-4893
Amorim, Maria
Amorim, Maria
https://www.ciencia-id.pt/CA1D-286D-A373
CA1D-286D-A373
http://orcid.org/0000-0002-9279-0921
0000-0002-9279-0921
Linden, David
Linden, David
http://orcid.org/0000-0002-5638-9292
0000-0002-5638-9292
Pinheiro, Ana P.
Pinheiro, Ana P.
https://www.ciencia-id.pt/6E1C-0855-073D
6E1C-0855-073D
http://orcid.org/0000-0002-7981-3682
0000-0002-7981-3682
Kotz, Sonja
Kotz, Sonja
http://orcid.org/0000-0002-5894-4624
0000-0002-5894-4624
publishDate 2023
reponame_str Repositório da Universidade de Lisboa
repository_id_str urn:repositoryAcronym:ul
service_str_mv urn:repositoryAcronym:ul
spelling engpt_PTResting state (RS) brain activity is inherently non-stationary. Hidden Semi-Markov Models (HsMM) can characterize the continuous RS data as a sequence of recurring and distinct brain states along with their spatio-temporal dynamics. Recent explorations suggest that EEG brain state dynamics in the alpha frequency link to auditory hallucination proneness (HP) in nonclinical individuals. The present study aims to replicate these findings to elucidate robust neural correlates of hallucinatory vulnerability. Specifically, we aimed to investigate the reproducibility of HsMM states across different data sets and within-data set variants as well as the replicability of the association between alpha brain state dynamics and HP. We found that most brain states are reproducible in different data sets, confirming that the HsMM characterized robust and generalizable EEG RS dynamics. Brain state topographies and temporal dynamics of different within-data set variants showed substantial similarities and were robust against reduced data length and number of electrodes. However, the association with HP was not directly reproducible across data sets. These results indicate that the sensitivity of brain state dynamics to capture individual variability in HP may depend on the data recording characteristics and individual variability in RS cognition, such as mind wandering. We suggest that the order in which eyes-open and eyes-closed RS data are acquired directly influences an individual’s attentional state and generation of spontaneous thoughts, and thereby might mediate the link to hallucinatory vulnerability.application/pdfpt_PTRevisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov ModelingPersonalHoncamp, HannaDSpacehttp://dspace.org/items/c42320df-7d8a-4c6c-a1bb-127f347d19adDSpacehttp://dspace.org/items/c42320df-7d8a-4c6c-a1bb-127f347d19adHoncampHannaORCIDhttp://orcid.org0009-0001-3373-9368PersonalSchwartze, MichaelDSpacehttp://dspace.org/items/1d97094b-0bd4-4147-b6a8-fe901dfcef47DSpacehttp://dspace.org/items/1d97094b-0bd4-4147-b6a8-fe901dfcef47SchwartzeMichaelCiência IDhttps://www.ciencia-id.pt1515-F9DE-0BA3ORCIDhttp://orcid.org0000-0003-3366-4893Scopus Author IDhttps://www.scopus.com35076531500PersonalAmorim, MariaDSpacehttp://dspace.org/items/7583a57c-6d7c-40c5-87d2-a077a7a390a9DSpacehttp://dspace.org/items/7583a57c-6d7c-40c5-87d2-a077a7a390a9AmorimMariaCiência IDhttps://www.ciencia-id.ptCA1D-286D-A373ORCIDhttp://orcid.org0000-0002-9279-0921PersonalLinden, DavidDSpacehttp://dspace.org/items/095051f3-4844-47c9-a3f1-5bc03836c9ceDSpacehttp://dspace.org/items/095051f3-4844-47c9-a3f1-5bc03836c9ceLindenDavidORCIDhttp://orcid.org0000-0002-5638-9292Researcher IDhttps://www.researcherid.comC-7355-2013PersonalPinheiro, Ana P.DSpacehttp://dspace.org/items/37dfa7cf-5d10-426c-b96f-34ba55489662DSpacehttp://dspace.org/items/37dfa7cf-5d10-426c-b96f-34ba55489662PinheiroAnaCiência IDhttps://www.ciencia-id.pt6E1C-0855-073DORCIDhttp://orcid.org0000-0002-7981-3682Scopus Author IDhttps://www.scopus.com36172795600PersonalKotz, SonjaDSpacehttp://dspace.org/items/57ed99c9-876a-4452-8c86-d9a48d550cacDSpacehttp://dspace.org/items/57ed99c9-876a-4452-8c86-d9a48d550cacKotzSonjaORCIDhttp://orcid.org0000-0002-5894-4624HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptDOIIsPartOf10.1101/2023.12.11.5710702024-02-22T16:54:59Z2023-12-122024-01-25T23:14:04Z2023-12-12T00:00:00ZHandlehttp://hdl.handle.net/10451/62851http://purl.org/coar/access_right/c_abf2open accessHidden Semi-Markov ModelResting stateAlpha dynamicsReproducibilityHallucination pronenessSpontaneous thoughts820189 bytesother research producthttp://purl.org/coar/resource_type/c_816bpreprinthttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/ce5899f4-eb90-4b3b-bee6-4912a6bff02a/download
spellingShingle Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
Honcamp, Hanna
Hidden Semi-Markov Model
Resting state
Alpha dynamics
Reproducibility
Hallucination proneness
Spontaneous thoughts
status SINGLETON
subject.fl_str_mv Hidden Semi-Markov Model
Resting state
Alpha dynamics
Reproducibility
Hallucination proneness
Spontaneous thoughts
title Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
title_full Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
title_fullStr Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
title_full_unstemmed Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
title_short Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
title_sort Revisiting Alpha Resting State Dynamics Underlying Hallucinatory Vulnerability: Insights from Hidden Semi-Markov Modeling
topic Hidden Semi-Markov Model
Resting state
Alpha dynamics
Reproducibility
Hallucination proneness
Spontaneous thoughts
topic_facet Hidden Semi-Markov Model
Resting state
Alpha dynamics
Reproducibility
Hallucination proneness
Spontaneous thoughts
url http://hdl.handle.net/10451/62851
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