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Origin of fasciculations in root lesions

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Resumo:Objective: Fasciculations are occasionally observed in root lesions, but their site of origin is uncertain. Methods: We studied the origin of fasciculations (FPs) in consecutive patients with mild chronic L5 root lesions, excluding peripheral nerve lesion. We used a novel technique of double-EMG needle recording, in which each needle was placed in the territory of separate motor units. With this technique the observation of synchronous FPs implies an origin proximal to distal axonal branching. Results: FPs were found in 13% of 84 consecutive patients with mild chronic L5 root lesions. In 25% they were synchronous in different motor units. Conclusions: We suggest that in mild L5 root lesions most FPs have an origin at distal branches but some FPs originate proximally (25%), possibly at the site of nerve compression. Significance: The proximal site of compression and more distal sites may both initiate fasciculation potentials in proximal root lesions.
Autores principais:Carvalho, Mamede
Outros Autores:Swash, Michael
Assunto:Fasciculation potentials Origin Reinnervation Root lesion
Ano:2016
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa
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author Carvalho, Mamede
author2 Swash, Michael
author2_role author
author_facet Carvalho, Mamede
Carvalho, Mamede
Swash, Michael
Swash, Michael
author_role author
contributor_name_str_mv Repositório Científico de Acesso Aberto da ULisboa
country_str PT
creators_json_str [{\"Person.name\":\"Carvalho, Mamede\",\"Person.identifier.orcid\":\"0000-0001-7556-0158\"},{\"Person.name\":\"Swash, Michael\",\"Person.identifier.orcid\":\"0000-0002-8717-8914\"}]
datacite.contributors.contributor.contributorName.fl_str_mv Repositório Científico de Acesso Aberto da ULisboa
datacite.creators.creator.creatorName.fl_str_mv Carvalho, Mamede
Swash, Michael
datacite.date.Accepted.fl_str_mv 2016-01-01T00:00:00Z
datacite.date.available.fl_str_mv 2022-06-21T14:51:11Z
datacite.date.embargoed.fl_str_mv 2022-06-21T14:51:11Z
datacite.rights.fl_str_mv http://purl.org/coar/access_right/c_16ec
datacite.subjects.subject.fl_str_mv Fasciculation potentials
Origin
Reinnervation
Root lesion
datacite.titles.title.fl_str_mv Origin of fasciculations in root lesions
dc.contributor.none.fl_str_mv Repositório Científico de Acesso Aberto da ULisboa
dc.creator.none.fl_str_mv Carvalho, Mamede
Swash, Michael
dc.date.Accepted.fl_str_mv 2016-01-01T00:00:00Z
dc.date.available.fl_str_mv 2022-06-21T14:51:11Z
dc.date.embargoed.fl_str_mv 2022-06-21T14:51:11Z
dc.format.none.fl_str_mv application/pdf
dc.identifier.none.fl_str_mv http://hdl.handle.net/10451/53423
dc.language.none.fl_str_mv eng
dc.publisher.none.fl_str_mv Elsevier
dc.rights.none.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.subject.none.fl_str_mv Fasciculation potentials
Origin
Reinnervation
Root lesion
dc.title.fl_str_mv Origin of fasciculations in root lesions
dc.type.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
description Objective: Fasciculations are occasionally observed in root lesions, but their site of origin is uncertain. Methods: We studied the origin of fasciculations (FPs) in consecutive patients with mild chronic L5 root lesions, excluding peripheral nerve lesion. We used a novel technique of double-EMG needle recording, in which each needle was placed in the territory of separate motor units. With this technique the observation of synchronous FPs implies an origin proximal to distal axonal branching. Results: FPs were found in 13% of 84 consecutive patients with mild chronic L5 root lesions. In 25% they were synchronous in different motor units. Conclusions: We suggest that in mild L5 root lesions most FPs have an origin at distal branches but some FPs originate proximally (25%), possibly at the site of nerve compression. Significance: The proximal site of compression and more distal sites may both initiate fasciculation potentials in proximal root lesions.
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eu_rights_str_mv restrictedAccess
format article
fulltext.url.fl_str_mv https://repositorio.ulisboa.pt/bitstreams/827f4f5f-c05e-4e42-87d4-066e25a85cb8/download
id ul_8e03e2e2e157f35dfde2bdd4e78dd5f9
identifier.url.fl_str_mv http://hdl.handle.net/10451/53423
instacron_str ul
institution Universidade de Lisboa
instname_str Universidade de Lisboa
language eng
network_acronym_str ul
network_name_str Repositório da Universidade de Lisboa
oai_identifier_str oai:repositorio.ulisboa.pt:10451/53423
organization_str_mv urn:organizationAcronym:ul
person_str_mv Carvalho, Mamede
Carvalho, Mamede
http://orcid.org/0000-0001-7556-0158
0000-0001-7556-0158
Swash, Michael
Swash, Michael
http://orcid.org/0000-0002-8717-8914
0000-0002-8717-8914
publishDate 2016
publisher.none.fl_str_mv Elsevier
reponame_str Repositório da Universidade de Lisboa
repository_id_str urn:repositoryAcronym:ul
service_str_mv urn:repositoryAcronym:ul
spelling engElsevierpt_PTObjective: Fasciculations are occasionally observed in root lesions, but their site of origin is uncertain. Methods: We studied the origin of fasciculations (FPs) in consecutive patients with mild chronic L5 root lesions, excluding peripheral nerve lesion. We used a novel technique of double-EMG needle recording, in which each needle was placed in the territory of separate motor units. With this technique the observation of synchronous FPs implies an origin proximal to distal axonal branching. Results: FPs were found in 13% of 84 consecutive patients with mild chronic L5 root lesions. In 25% they were synchronous in different motor units. Conclusions: We suggest that in mild L5 root lesions most FPs have an origin at distal branches but some FPs originate proximally (25%), possibly at the site of nerve compression. Significance: The proximal site of compression and more distal sites may both initiate fasciculation potentials in proximal root lesions.application/pdfpt_PTOrigin of fasciculations in root lesionsPersonalCarvalho, MamedeDSpacehttp://dspace.org/items/dd7f55d4-c2b5-4fd2-9bd1-a9542a62f58fDSpacehttp://dspace.org/items/dd7f55d4-c2b5-4fd2-9bd1-a9542a62f58fde CarvalhoMamedeORCIDhttp://orcid.org0000-0001-7556-0158Scopus Author IDhttps://www.scopus.com7101893769PersonalSwash, MichaelDSpacehttp://dspace.org/items/c6014014-de11-4f31-ac1a-096c54052517DSpacehttp://dspace.org/items/c6014014-de11-4f31-ac1a-096c54052517SwashMichaelORCIDhttp://orcid.org0000-0002-8717-8914Scopus Author IDhttps://www.scopus.com7101990692HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf1388-2457DOIIsPartOf10.1016/j.clinph.2015.02.0042022-06-21T14:51:11Z20162016-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/53423http://purl.org/coar/access_right/c_16ecrestricted accessFasciculation potentialsOriginReinnervationRoot lesion431620 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/827f4f5f-c05e-4e42-87d4-066e25a85cb8/downloadClinical Neurophysiology1271870873
spellingShingle Origin of fasciculations in root lesions
Origin of fasciculations in root lesions
Carvalho, Mamede
Fasciculation potentials
Origin
Reinnervation
Root lesion
Carvalho, Mamede
Fasciculation potentials
Origin
Reinnervation
Root lesion
status SINGLETON
subject.fl_str_mv Fasciculation potentials
Origin
Reinnervation
Root lesion
title Origin of fasciculations in root lesions
title_full Origin of fasciculations in root lesions
title_fullStr Origin of fasciculations in root lesions
Origin of fasciculations in root lesions
title_full_unstemmed Origin of fasciculations in root lesions
Origin of fasciculations in root lesions
title_short Origin of fasciculations in root lesions
title_sort Origin of fasciculations in root lesions
topic Fasciculation potentials
Origin
Reinnervation
Root lesion
topic_facet Fasciculation potentials
Origin
Reinnervation
Root lesion
url http://hdl.handle.net/10451/53423
visible 1