Publicação
Predictors of functional capacity in patients with pulmonary hypertension
| Resumo: | Introduction: The 6-minute walk test (6 MWT) distance is frequently used in the prediction of pulmonary hypertension (PH) prognosis. However, potential surrogates of this measure have not been established. We aim to describe the clinical, echocardiographic, and laboratorial criteria determining the 6 MWT distance in patients with PH. Methods: In 22 consecutive PH patients, functional capacity was evaluated by the 6 MWT distance and compared with levels of neurohormonal activation biomarkers and echocardiographic parameters for right ventricular (RV) function. Results: A correlation between the 6 MWT distance and several clinical parameters was found: Borg’s pre-test classification (R=-0.46; p=0.038); WHO functional class (p=0.029). Patients with higher levels of aldosterone (R=-0.46; p=0.030), renin (R=-0.43; p=0.046) and mid-regional pro-adrenomedullin (MR-proADM, R=-0.53; p=0.009) had worse 6 MWT performance. The opposite was true for natremia levels (R=0.55; p=0.006). There was a positive correlation between the 6 MWT distance and RV global longitudinal peak systolic strain rate and early diastolic strain rate (R=0.49; p=0.038 and R=-0.55; p=0.018, respectively). On multivariate analysis, only natremia and early diastolic strain rate were predictors of the 6 MWT distance. Conclusion: The 6 MWT distance correlated with renin-angiotensin-aldosterone system activation and parameters for RV myocardial deformation. The new biomarker MR-proADM proved to be useful in the prediction of the functional capacity. |
|---|---|
| Autores principais: | Plácido, Rui |
| Outros Autores: | Martins, Susana; Marques, João Silva; Kovell, Lara; Gonçalves, Susana; Almeida, Ana G.; Diogo, António Nunes; Pinto, Fausto J. |
| Assunto: | Pulmonary hypertension 6-Minute walk test Biomarkers Echocardiography Prognosis |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866811420841082880 |
|---|---|
| author | Plácido, Rui |
| author2 | Martins, Susana Marques, João Silva Kovell, Lara Gonçalves, Susana Almeida, Ana G. Diogo, António Nunes Pinto, Fausto J. |
| author2_role | author author author author author author author |
| author_facet | Plácido, Rui Martins, Susana Marques, João Silva Kovell, Lara Gonçalves, Susana Almeida, Ana G. Diogo, António Nunes Pinto, Fausto J. |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Plácido, Rui\"},{\"Person.name\":\"Martins, Susana\"},{\"Person.name\":\"Marques, João Silva\"},{\"Person.name\":\"Kovell, Lara\"},{\"Person.name\":\"Gonçalves, Susana\"},{\"Person.name\":\"Almeida, Ana G.\",\"Person.identifier.orcid\":\"0000-0003-0360-4363\"},{\"Person.name\":\"Diogo, António Nunes\"},{\"Person.name\":\"Pinto, Fausto J.\",\"Person.identifier.orcid\":\"0000-0002-8034-4529\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Plácido, Rui Martins, Susana Marques, João Silva Kovell, Lara Gonçalves, Susana Almeida, Ana G. Diogo, António Nunes Pinto, Fausto J. |
| datacite.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-07-18T14:53:50Z |
| datacite.date.embargoed.fl_str_mv | 2018-07-18T14:53:50Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Pulmonary hypertension 6-Minute walk test Biomarkers Echocardiography Prognosis |
| datacite.titles.title.fl_str_mv | Predictors of functional capacity in patients with pulmonary hypertension |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Plácido, Rui Martins, Susana Marques, João Silva Kovell, Lara Gonçalves, Susana Almeida, Ana G. Diogo, António Nunes Pinto, Fausto J. |
| dc.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-07-18T14:53:50Z |
| dc.date.embargoed.fl_str_mv | 2018-07-18T14:53:50Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/34242 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | OMICS International |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Pulmonary hypertension 6-Minute walk test Biomarkers Echocardiography Prognosis |
| dc.title.fl_str_mv | Predictors of functional capacity in patients with pulmonary hypertension |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: The 6-minute walk test (6 MWT) distance is frequently used in the prediction of pulmonary hypertension (PH) prognosis. However, potential surrogates of this measure have not been established. We aim to describe the clinical, echocardiographic, and laboratorial criteria determining the 6 MWT distance in patients with PH. Methods: In 22 consecutive PH patients, functional capacity was evaluated by the 6 MWT distance and compared with levels of neurohormonal activation biomarkers and echocardiographic parameters for right ventricular (RV) function. Results: A correlation between the 6 MWT distance and several clinical parameters was found: Borg’s pre-test classification (R=-0.46; p=0.038); WHO functional class (p=0.029). Patients with higher levels of aldosterone (R=-0.46; p=0.030), renin (R=-0.43; p=0.046) and mid-regional pro-adrenomedullin (MR-proADM, R=-0.53; p=0.009) had worse 6 MWT performance. The opposite was true for natremia levels (R=0.55; p=0.006). There was a positive correlation between the 6 MWT distance and RV global longitudinal peak systolic strain rate and early diastolic strain rate (R=0.49; p=0.038 and R=-0.55; p=0.018, respectively). On multivariate analysis, only natremia and early diastolic strain rate were predictors of the 6 MWT distance. Conclusion: The 6 MWT distance correlated with renin-angiotensin-aldosterone system activation and parameters for RV myocardial deformation. The new biomarker MR-proADM proved to be useful in the prediction of the functional capacity. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/7a1663b9-e48a-4638-8171-65c2d9ce9894/download |
| id | ul_93d3c8dadbb34a375d1613dc2d7c8f8b |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/34242 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/34242 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Plácido, Rui Martins, Susana Marques, João Silva Kovell, Lara Gonçalves, Susana Almeida, Ana G. Almeida, Ana G. https://www.ciencia-id.pt/3610-3184-3042 3610-3184-3042 http://orcid.org/0000-0003-0360-4363 0000-0003-0360-4363 Diogo, António Nunes Pinto, Fausto J. Pinto, Fausto J. https://www.ciencia-id.pt/C311-AEDD-6DBB C311-AEDD-6DBB http://orcid.org/0000-0002-8034-4529 0000-0002-8034-4529 |
| publishDate | 2015 |
| publisher.none.fl_str_mv | OMICS International |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engOMICS Internationalpt_PTIntroduction: The 6-minute walk test (6 MWT) distance is frequently used in the prediction of pulmonary hypertension (PH) prognosis. However, potential surrogates of this measure have not been established. We aim to describe the clinical, echocardiographic, and laboratorial criteria determining the 6 MWT distance in patients with PH. Methods: In 22 consecutive PH patients, functional capacity was evaluated by the 6 MWT distance and compared with levels of neurohormonal activation biomarkers and echocardiographic parameters for right ventricular (RV) function. Results: A correlation between the 6 MWT distance and several clinical parameters was found: Borg’s pre-test classification (R=-0.46; p=0.038); WHO functional class (p=0.029). Patients with higher levels of aldosterone (R=-0.46; p=0.030), renin (R=-0.43; p=0.046) and mid-regional pro-adrenomedullin (MR-proADM, R=-0.53; p=0.009) had worse 6 MWT performance. The opposite was true for natremia levels (R=0.55; p=0.006). There was a positive correlation between the 6 MWT distance and RV global longitudinal peak systolic strain rate and early diastolic strain rate (R=0.49; p=0.038 and R=-0.55; p=0.018, respectively). On multivariate analysis, only natremia and early diastolic strain rate were predictors of the 6 MWT distance. Conclusion: The 6 MWT distance correlated with renin-angiotensin-aldosterone system activation and parameters for RV myocardial deformation. The new biomarker MR-proADM proved to be useful in the prediction of the functional capacity.application/pdfpt_PTPredictors of functional capacity in patients with pulmonary hypertensionPlácido, RuiMartins, SusanaMarques, João SilvaKovell, LaraGonçalves, SusanaPersonalAlmeida, Ana G.DSpacehttp://dspace.org/items/7a34cb7e-96d7-426c-ac32-346c0c0fa68cDSpacehttp://dspace.org/items/7a34cb7e-96d7-426c-ac32-346c0c0fa68cAlmeidaAna Gomes deCiência IDhttps://www.ciencia-id.pt3610-3184-3042ORCIDhttp://orcid.org0000-0003-0360-4363Scopus Author IDhttps://www.scopus.com55628683100Diogo, António NunesPersonalPinto, Fausto J.DSpacehttp://dspace.org/items/5f44176f-69f5-482c-83cd-ab94425a6ec3DSpacehttp://dspace.org/items/5f44176f-69f5-482c-83cd-ab94425a6ec3PintoFausto J.Ciência IDhttps://www.ciencia-id.ptC311-AEDD-6DBBORCIDhttp://orcid.org0000-0002-8034-4529Researcher IDhttps://www.researcherid.comG-9363-2015Researcher IDhttps://www.researcherid.comGQA-4584-2022Scopus Author IDhttps://www.scopus.com7102740158HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf2161-105XDOIIsPartOf10.4172/2161-105X.10002902018-07-18T14:53:50Z20152015-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/34242http://purl.org/coar/access_right/c_abf2open accessPulmonary hypertension6-Minute walk testBiomarkersEchocardiographyPrognosis774978 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2015http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/7a1663b9-e48a-4638-8171-65c2d9ce9894/downloadJournal of Pulmonary and Respiratory Medicine0505 |
| spellingShingle | Predictors of functional capacity in patients with pulmonary hypertension Plácido, Rui Pulmonary hypertension 6-Minute walk test Biomarkers Echocardiography Prognosis |
| status | SINGLETON |
| subject.fl_str_mv | Pulmonary hypertension 6-Minute walk test Biomarkers Echocardiography Prognosis |
| title | Predictors of functional capacity in patients with pulmonary hypertension |
| title_full | Predictors of functional capacity in patients with pulmonary hypertension |
| title_fullStr | Predictors of functional capacity in patients with pulmonary hypertension |
| title_full_unstemmed | Predictors of functional capacity in patients with pulmonary hypertension |
| title_short | Predictors of functional capacity in patients with pulmonary hypertension |
| title_sort | Predictors of functional capacity in patients with pulmonary hypertension |
| topic | Pulmonary hypertension 6-Minute walk test Biomarkers Echocardiography Prognosis |
| topic_facet | Pulmonary hypertension 6-Minute walk test Biomarkers Echocardiography Prognosis |
| url | http://hdl.handle.net/10451/34242 |
| visible | 1 |