Publicação
Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation
| Resumo: | Valproic acid (VPA; 2-n-propylpentanoic acid) is widely used as a major drug in the treatment of epilepsy and in the control of several types of seizures. Being a simple fatty acid, VPA is a substrate for the fatty acid P-oxidation (FAO) pathway, which takes place primarily in mitochondria. The toxicity of valproate has long been considered to be due primarily to its interference with mitochondrial P-oxidation. The metabolism of the drug, its effects on enzymes of FAO and their cofactors such as CoA and/or carnitine will be reviewed. The cumulative consequences of VPA therapy in inborn errors of metabolism (IEMs) and the importance of recognizing an underlying IEM in cases of VPA-induced steatosis and acute liver toxicity are two different concepts that will be emphasized. |
|---|---|
| Autores principais: | Silva, M. F. B. |
| Outros Autores: | Aires, C. C. P.; Luis, P. B. M.; Ruiter, J. P. N.; IJist, L.; Duran, M.; Wanders, R. J. A.; de Almeida, I. Tavares |
| Assunto: | Endocrinology & Metabolism Genetics & Heredity |
| Ano: | 2008 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso a metadados |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866810620107554816 |
|---|---|
| author | Silva, M. F. B. |
| author2 | Aires, C. C. P. Luis, P. B. M. Ruiter, J. P. N. IJist, L. Duran, M. Wanders, R. J. A. de Almeida, I. Tavares |
| author2_role | author author author author author author author |
| author_facet | Silva, M. F. B. Aires, C. C. P. Luis, P. B. M. Ruiter, J. P. N. IJist, L. Duran, M. Wanders, R. J. A. de Almeida, I. Tavares |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Silva, M. F. B.\"},{\"Person.name\":\"Aires, C. C. P.\"},{\"Person.name\":\"Luis, P. B. M.\"},{\"Person.name\":\"Ruiter, J. P. N.\"},{\"Person.name\":\"IJist, L.\"},{\"Person.name\":\"Duran, M.\"},{\"Person.name\":\"Wanders, R. J. A.\"},{\"Person.name\":\"de Almeida, I. Tavares\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Silva, M. F. B. Aires, C. C. P. Luis, P. B. M. Ruiter, J. P. N. IJist, L. Duran, M. Wanders, R. J. A. de Almeida, I. Tavares |
| datacite.date.Accepted.fl_str_mv | 2008-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2015-12-30T10:18:36Z |
| datacite.date.embargoed.fl_str_mv | 2015-12-30T10:18:36Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_14cb |
| datacite.subjects.subject.fl_str_mv | Endocrinology & Metabolism Genetics & Heredity |
| datacite.titles.title.fl_str_mv | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation A review |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Silva, M. F. B. Aires, C. C. P. Luis, P. B. M. Ruiter, J. P. N. IJist, L. Duran, M. Wanders, R. J. A. de Almeida, I. Tavares |
| dc.date.Accepted.fl_str_mv | 2008-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2015-12-30T10:18:36Z |
| dc.date.embargoed.fl_str_mv | 2015-12-30T10:18:36Z |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/21686 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | DORDRECHT |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_14cb |
| dc.subject.none.fl_str_mv | Endocrinology & Metabolism Genetics & Heredity |
| dc.title.fl_str_mv | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation A review |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Valproic acid (VPA; 2-n-propylpentanoic acid) is widely used as a major drug in the treatment of epilepsy and in the control of several types of seizures. Being a simple fatty acid, VPA is a substrate for the fatty acid P-oxidation (FAO) pathway, which takes place primarily in mitochondria. The toxicity of valproate has long been considered to be due primarily to its interference with mitochondrial P-oxidation. The metabolism of the drug, its effects on enzymes of FAO and their cofactors such as CoA and/or carnitine will be reviewed. The cumulative consequences of VPA therapy in inborn errors of metabolism (IEMs) and the importance of recognizing an underlying IEM in cases of VPA-induced steatosis and acute liver toxicity are two different concepts that will be emphasized. |
| dirty | 0 |
| eu_rights_str_mv | metadataOnlyAccess |
| format | article |
| id | ul_97f39cc71ba39dc2e1345910f8ea4680 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/21686 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/21686 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Silva, M. F. B. Aires, C. C. P. Luis, P. B. M. Ruiter, J. P. N. IJist, L. Duran, M. Wanders, R. J. A. de Almeida, I. Tavares |
| publishDate | 2008 |
| publisher.none.fl_str_mv | DORDRECHT |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engDORDRECHTValproic acid (VPA; 2-n-propylpentanoic acid) is widely used as a major drug in the treatment of epilepsy and in the control of several types of seizures. Being a simple fatty acid, VPA is a substrate for the fatty acid P-oxidation (FAO) pathway, which takes place primarily in mitochondria. The toxicity of valproate has long been considered to be due primarily to its interference with mitochondrial P-oxidation. The metabolism of the drug, its effects on enzymes of FAO and their cofactors such as CoA and/or carnitine will be reviewed. The cumulative consequences of VPA therapy in inborn errors of metabolism (IEMs) and the importance of recognizing an underlying IEM in cases of VPA-induced steatosis and acute liver toxicity are two different concepts that will be emphasized.Valproic acid metabolism and its effects on mitochondrial fatty acid oxidationA reviewSilva, M. F. B.Aires, C. C. P.Luis, P. B. M.Ruiter, J. P. N.IJist, L.Duran, M.Wanders, R. J. A.de Almeida, I. TavaresHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISBNIsPartOfChild Hlth, Great ODOIIsPartOfhttp://dx.doi.org/10.1007/s10545-008-0841-x2015-12-30T10:18:36Z20082008-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/21686http://purl.org/coar/access_right/c_14cbmetadata only accessEndocrinology & MetabolismGenetics & Heredityliteraturehttp://purl.org/coar/resource_type/c_6501journal article205216 |
| spellingShingle | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation Silva, M. F. B. Endocrinology & Metabolism Genetics & Heredity |
| status | SINGLETON |
| subject.fl_str_mv | Endocrinology & Metabolism Genetics & Heredity |
| title | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation |
| title_full | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation |
| title_fullStr | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation |
| title_full_unstemmed | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation |
| title_short | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation |
| title_sort | Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation |
| topic | Endocrinology & Metabolism Genetics & Heredity |
| topic_facet | Endocrinology & Metabolism Genetics & Heredity |
| url | http://hdl.handle.net/10451/21686 |
| visible | 1 |