Publicação
The significance of circulating tumour cells in the clinic
| Resumo: | Background: Despite the hype about circulating tumour cells (CTCs) in the early 2000s and their potential in the diagnosis of metastasis, in recent years, the hope for personalised cancer management relies more on circulating tumour (ct)DNA that has entered the clinic in a much more efficient way. So far, approved methods for CTCs in the clinic only provide the counting of CTCs, which enables monitoring of the progression of metastatic breast, prostate, and colorectal cancer patients with therapy. Approved methods for ctDNA facilitate the analysis of specific mutations in lung cancer, thereby providing indications for potentially successful treatments. This situation inclined the balance towards molecular analysis in liquid biopsy, leveraged by new technologies and companies providing broader mutation and gene expression analysis towards the early diagnosis of cancer. Study design: We conducted a search for the studies published to date that provide details about the significance of CTCs in the clinic. Results: Many studies and clinical trials have demonstrated the potential of CTCs in patient screening, early diagnosis, therapy resistance, and patient prognosis. Conclusions: Large multi-centre studies are still needed to formally validate the clinical relevance of CTCs. Meticulous design of the clinical trials is a crucial point to achieve this long-sought objective. |
|---|---|
| Autores principais: | Abalde Cela, Sara |
| Outros Autores: | Piairo, Paulina; Diéguez, Lorena |
| Assunto: | Cancer prognosis CellSearch® Circulating tumour cells Epithelial-mesenchymal transition Liquid biopsy Personalised medicine |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1865920822020931584 |
|---|---|
| author | Abalde Cela, Sara |
| author2 | Piairo, Paulina Diéguez, Lorena |
| author2_role | author author |
| author_facet | Abalde Cela, Sara Abalde Cela, Sara Piairo, Paulina Diéguez, Lorena Piairo, Paulina Diéguez, Lorena |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Abalde Cela, Sara\"},{\"Person.name\":\"Piairo, Paulina\",\"Person.identifier.orcid\":\"0000-0003-1905-671X\"},{\"Person.name\":\"Diéguez, Lorena\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Abalde Cela, Sara Piairo, Paulina Diéguez, Lorena |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-03-25T16:02:47Z |
| datacite.date.embargoed.fl_str_mv | 2021-03-25T16:02:47Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Cancer prognosis CellSearch® Circulating tumour cells Epithelial-mesenchymal transition Liquid biopsy Personalised medicine |
| datacite.titles.title.fl_str_mv | The significance of circulating tumour cells in the clinic |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Abalde Cela, Sara Piairo, Paulina Diéguez, Lorena |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-03-25T16:02:47Z |
| dc.date.embargoed.fl_str_mv | 2021-03-25T16:02:47Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/47073 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Karger |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Cancer prognosis CellSearch® Circulating tumour cells Epithelial-mesenchymal transition Liquid biopsy Personalised medicine |
| dc.title.fl_str_mv | The significance of circulating tumour cells in the clinic |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: Despite the hype about circulating tumour cells (CTCs) in the early 2000s and their potential in the diagnosis of metastasis, in recent years, the hope for personalised cancer management relies more on circulating tumour (ct)DNA that has entered the clinic in a much more efficient way. So far, approved methods for CTCs in the clinic only provide the counting of CTCs, which enables monitoring of the progression of metastatic breast, prostate, and colorectal cancer patients with therapy. Approved methods for ctDNA facilitate the analysis of specific mutations in lung cancer, thereby providing indications for potentially successful treatments. This situation inclined the balance towards molecular analysis in liquid biopsy, leveraged by new technologies and companies providing broader mutation and gene expression analysis towards the early diagnosis of cancer. Study design: We conducted a search for the studies published to date that provide details about the significance of CTCs in the clinic. Results: Many studies and clinical trials have demonstrated the potential of CTCs in patient screening, early diagnosis, therapy resistance, and patient prognosis. Conclusions: Large multi-centre studies are still needed to formally validate the clinical relevance of CTCs. Meticulous design of the clinical trials is a crucial point to achieve this long-sought objective. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/980ebf63-de60-4233-b9cb-28f613b6d27a/download |
| funding.funder.alternateName_str_mv | EC |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100008530 |
| funding.funder.name_str_mv | European Commission |
| funding.name_str_mv | H2020 |
| id | ul_9dfd0634cdeeccf440ef0726309e1588 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/47073 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/47073 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Abalde Cela, Sara Piairo, Paulina Piairo, Paulina https://www.ciencia-id.pt/D610-0D47-1B5B D610-0D47-1B5B http://orcid.org/0000-0003-1905-671X 0000-0003-1905-671X Diéguez, Lorena |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Karger |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engKargerpt_PTBackground: Despite the hype about circulating tumour cells (CTCs) in the early 2000s and their potential in the diagnosis of metastasis, in recent years, the hope for personalised cancer management relies more on circulating tumour (ct)DNA that has entered the clinic in a much more efficient way. So far, approved methods for CTCs in the clinic only provide the counting of CTCs, which enables monitoring of the progression of metastatic breast, prostate, and colorectal cancer patients with therapy. Approved methods for ctDNA facilitate the analysis of specific mutations in lung cancer, thereby providing indications for potentially successful treatments. This situation inclined the balance towards molecular analysis in liquid biopsy, leveraged by new technologies and companies providing broader mutation and gene expression analysis towards the early diagnosis of cancer. Study design: We conducted a search for the studies published to date that provide details about the significance of CTCs in the clinic. Results: Many studies and clinical trials have demonstrated the potential of CTCs in patient screening, early diagnosis, therapy resistance, and patient prognosis. Conclusions: Large multi-centre studies are still needed to formally validate the clinical relevance of CTCs. Meticulous design of the clinical trials is a crucial point to achieve this long-sought objective.application/pdfpt_PTThe significance of circulating tumour cells in the clinicAbalde Cela, SaraPersonalPiairo, PaulinaDSpacehttp://dspace.org/items/9a335f15-9712-49f2-85d7-26939a4de2d5DSpacehttp://dspace.org/items/9a335f15-9712-49f2-85d7-26939a4de2d5DA COSTA PIAIROPAULINA FLÁVIACiência IDhttps://www.ciencia-id.ptD610-0D47-1B5BORCIDhttp://orcid.org0000-0003-1905-671XDiéguez, LorenaHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0001-5547DOIIsPartOf10.1159/0004954172021-03-25T16:02:47Z20192019-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/47073http://purl.org/coar/access_right/c_16ecrestricted accessCancer prognosisCellSearch®Circulating tumour cellsEpithelial-mesenchymal transitionLiquid biopsyPersonalised medicine571025 bytesEuropean CommissionINL Fellowship programme in nanotechnologies for nanomedicine, energy, ICT, food and environment applicationsH2020Crossref Funder IDhttp://doi.org/10.13039/501100008530literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/980ebf63-de60-4233-b9cb-28f613b6d27a/downloadActa Cytologica636466478 |
| spellingShingle | The significance of circulating tumour cells in the clinic The significance of circulating tumour cells in the clinic Abalde Cela, Sara Cancer prognosis CellSearch® Circulating tumour cells Epithelial-mesenchymal transition Liquid biopsy Personalised medicine Abalde Cela, Sara Cancer prognosis CellSearch® Circulating tumour cells Epithelial-mesenchymal transition Liquid biopsy Personalised medicine |
| status | SINGLETON |
| subject.fl_str_mv | Cancer prognosis CellSearch® Circulating tumour cells Epithelial-mesenchymal transition Liquid biopsy Personalised medicine |
| title | The significance of circulating tumour cells in the clinic |
| title_full | The significance of circulating tumour cells in the clinic |
| title_fullStr | The significance of circulating tumour cells in the clinic The significance of circulating tumour cells in the clinic |
| title_full_unstemmed | The significance of circulating tumour cells in the clinic The significance of circulating tumour cells in the clinic |
| title_short | The significance of circulating tumour cells in the clinic |
| title_sort | The significance of circulating tumour cells in the clinic |
| topic | Cancer prognosis CellSearch® Circulating tumour cells Epithelial-mesenchymal transition Liquid biopsy Personalised medicine |
| topic_facet | Cancer prognosis CellSearch® Circulating tumour cells Epithelial-mesenchymal transition Liquid biopsy Personalised medicine |
| url | http://hdl.handle.net/10451/47073 |
| visible | 1 |