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Translation of liver stage activity of M5717, a Plasmodium elongation factor 2 inhibitor: from bench to bedside

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Resumo:Background: Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. Methods: M5717, a Plasmodium elongation factor 2 inhibitor, was assessed in vitro and in vivo with readily accessible Plasmodium berghei parasites. In an animal refinement, reduction, replacement approach, the in vitro IC99 value was used to feed a Population Pharmacokinetics modelling and simulation approach to determine meaningful effective doses for a subsequent Plasmodium sporozoite-induced volunteer infection study. Results: Doses of 100 and 200 mg would provide exposures exceeding IC99 in 96 and 100% of the simulated population, respectively. Conclusions: This approach has the potential to accelerate the search for new anti-malarials, to reduce the number of healthy volunteers needed in a clinical study and decrease and refine the animal use in the preclinical phase.
Autores principais:Khandelwal, Akash
Outros Autores:Arez, Francisca; Alves, Paula M.; Badolo, Lassina; Brito, Catarina; Fischli, Christoph; Fontinha, Diana; Oeuvray, Claude; Prudêncio, Miguel; Rottmann, Matthias; Wilkins, Justin; Yalkinoglu, Özkan; Bagchus, Wilhelmina M.; Spangenberg, Thomas
Assunto:3R Hepatic M5717 Modelling Plasmodium elongation factor 2 Population Pharmacokinetics Spheroids
Ano:2022
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa

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