Publicação
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia
| _version_ | 1866810844532178944 |
|---|---|
| author | Tsvetanov, Kamen A. |
| author2 | Gazzina, Stefano Jones, P. Simon Swieten, John Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Moore, Katrina M Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Panman, Jessica Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Papma, Janne Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans‐Otto Institutet, Karolinska Keren, Ron Langheinrich, Tobias Leitão, Maria João Lladó, Albert Lombardi, Gemma Piaceri, Irene Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Pievani, Michela Olives, Jaume Padovani, Alessandro Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Masellis, Mario Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa‐Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Tartaglia, Maria Carmela Shafei, Rachelle Shoesmith, Christen Tábuas‐Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang‐Wai, David Thomas, David L Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Finger, Elizabeth Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Vandenberghe, Rik Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Ghidoni, Roberta Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl‐Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego‐Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Tsvetanov, Kamen A. Gazzina, Stefano Jones, P. Simon Swieten, John Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Moore, Katrina M Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Panman, Jessica Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Papma, Janne Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans‐Otto Institutet, Karolinska Keren, Ron Langheinrich, Tobias Leitão, Maria João Lladó, Albert Lombardi, Gemma Piaceri, Irene Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Pievani, Michela Olives, Jaume Padovani, Alessandro Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Masellis, Mario Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa‐Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Tartaglia, Maria Carmela Shafei, Rachelle Shoesmith, Christen Tábuas‐Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang‐Wai, David Thomas, David L Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Finger, Elizabeth Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Vandenberghe, Rik Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Ghidoni, Roberta Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl‐Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego‐Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Tsvetanov, Kamen A.\"},{\"Person.name\":\"Gazzina, Stefano\"},{\"Person.name\":\"Jones, P. Simon\"},{\"Person.name\":\"Swieten, John\"},{\"Person.name\":\"Borroni, Barbara\"},{\"Person.name\":\"Sanchez‐Valle, Raquel\"},{\"Person.name\":\"Moreno, Fermin\"},{\"Person.name\":\"Laforce, Robert\"},{\"Person.name\":\"Graff, Caroline\"},{\"Person.name\":\"Synofzik, Matthis\"},{\"Person.name\":\"Galimberti, Daniela\"},{\"Person.name\":\"Moore, Katrina M\"},{\"Person.name\":\"Duro, Diana\"},{\"Person.name\":\"Fenoglio, Chiara\"},{\"Person.name\":\"Ferrari, Camilla\"},{\"Person.name\":\"Ferreira, Carlos\"},{\"Person.name\":\"Ferreira, Catarina B.\"},{\"Person.name\":\"Flanagan, Toby\"},{\"Person.name\":\"Fox, Nick\"},{\"Person.name\":\"Freedman, Morris\"},{\"Person.name\":\"Fumagalli, Giorgio\"},{\"Person.name\":\"Panman, Jessica\"},{\"Person.name\":\"Gabilondo, Alazne\"},{\"Person.name\":\"Gasparotti, Roberto\"},{\"Person.name\":\"Gauthier, Serge\"},{\"Person.name\":\"Gazzina, Stefano\"},{\"Person.name\":\"Giaccone, Giorgio\"},{\"Person.name\":\"Gorostidi, Ana\"},{\"Person.name\":\"Greaves, Caroline\"},{\"Person.name\":\"Guerreiro, Rita\"},{\"Person.name\":\"Heller, Carolin\"},{\"Person.name\":\"Hoegen, Tobias\"},{\"Person.name\":\"Papma, Janne\"},{\"Person.name\":\"Indakoetxea, Begoña\"},{\"Person.name\":\"Jelic, Vesna\"},{\"Person.name\":\"Jiskoot, Lize\"},{\"Person.name\":\"Karnath, Hans‐Otto\"},{\"Person.name\":\"Institutet, Karolinska\"},{\"Person.name\":\"Keren, Ron\"},{\"Person.name\":\"Langheinrich, Tobias\"},{\"Person.name\":\"Leitão, Maria João\"},{\"Person.name\":\"Lladó, Albert\"},{\"Person.name\":\"Lombardi, Gemma\"},{\"Person.name\":\"Piaceri, Irene\"},{\"Person.name\":\"Loosli, Sandra\"},{\"Person.name\":\"Maruta, Carolina\",\"Person.identifier.orcid\":\"0000-0003-3359-379X\"},{\"Person.name\":\"Mead, Simon\"},{\"Person.name\":\"Meeter, Lieke\"},{\"Person.name\":\"Miltenberger-Miltenyi, Gabriel\",\"Person.identifier.orcid\":\"0000-0003-0224-1281\"},{\"Person.name\":\"van Minkelen, Rick\"},{\"Person.name\":\"Mitchell, Sara\"},{\"Person.name\":\"Nacmias, Benedetta\"},{\"Person.name\":\"Neason, Mollie\"},{\"Person.name\":\"Nicholas, Jennifer\"},{\"Person.name\":\"Pievani, Michela\"},{\"Person.name\":\"Olives, Jaume\"},{\"Person.name\":\"Padovani, Alessandro\"},{\"Person.name\":\"Pijnenburg, Yolande\"},{\"Person.name\":\"Polito, Cristina\"},{\"Person.name\":\"Premi, Enrico\"},{\"Person.name\":\"Prioni, Sara\"},{\"Person.name\":\"Prix, Catharina\"},{\"Person.name\":\"Rademakers, Rosa\"},{\"Person.name\":\"Masellis, Mario\"},{\"Person.name\":\"Redaelli, Veronica\"},{\"Person.name\":\"Rittman, Tim\"},{\"Person.name\":\"Rogaeva, Ekaterina\"},{\"Person.name\":\"Rosa‐Neto, Pedro\"},{\"Person.name\":\"Rossi, Giacomina\"},{\"Person.name\":\"Rossor, Martin\"},{\"Person.name\":\"Santiago, Beatriz\"},{\"Person.name\":\"Scarpini, Elio\"},{\"Person.name\":\"Schönecker, Sonja\"},{\"Person.name\":\"Semler, Elisa\"},{\"Person.name\":\"Tartaglia, Maria Carmela\"},{\"Person.name\":\"Shafei, Rachelle\"},{\"Person.name\":\"Shoesmith, Christen\"},{\"Person.name\":\"Tábuas‐Pereira, Miguel\"},{\"Person.name\":\"Tainta, Mikel\"},{\"Person.name\":\"Taipa, Ricardo\"},{\"Person.name\":\"Tang‐Wai, David\"},{\"Person.name\":\"Thomas, David L\"},{\"Person.name\":\"Thompson, Paul\"},{\"Person.name\":\"Thonberg, Hakan\"},{\"Person.name\":\"Timberlake, Carolyn\"},{\"Person.name\":\"Finger, Elizabeth\"},{\"Person.name\":\"Tiraboschi, Pietro\"},{\"Person.name\":\"Vandamme, Philip\"},{\"Person.name\":\"Vandenbulcke, Mathieu\"},{\"Person.name\":\"Veldsman, Michele\"},{\"Person.name\":\"Verdelho, Ana\",\"Person.identifier.orcid\":\"0000-0003-4945-4946\"},{\"Person.name\":\"Villanua, Jorge\"},{\"Person.name\":\"Warren, Jason\"},{\"Person.name\":\"Wilke, Carlo\"},{\"Person.name\":\"Woollacott, Ione\"},{\"Person.name\":\"Wlasich, Elisabeth\"},{\"Person.name\":\"Vandenberghe, Rik\"},{\"Person.name\":\"Zetterberg, Henrik\"},{\"Person.name\":\"Zulaica, Miren\"},{\"Person.name\":\"De Mendonça, Alexandre\",\"Person.identifier.orcid\":\"0000-0002-0488-1453\"},{\"Person.name\":\"Tagliavini, Fabrizio\"},{\"Person.name\":\"Santana, Isabel\"},{\"Person.name\":\"Ducharme, Simon\"},{\"Person.name\":\"Butler, Chris\"},{\"Person.name\":\"Gerhard, Alexander\"},{\"Person.name\":\"Danek, Adrian\"},{\"Person.name\":\"Levin, Johannes\"},{\"Person.name\":\"Otto, Markus\"},{\"Person.name\":\"Frisoni, Giovanni\"},{\"Person.name\":\"Ghidoni, Roberta\"},{\"Person.name\":\"Sorbi, Sandro\"},{\"Person.name\":\"Rohrer, Jonathan D.\"},{\"Person.name\":\"Rowe, James B.\"},{\"Person.name\":\"Afonso, Sónia\"},{\"Person.name\":\"Almeida, Maria Rosario\"},{\"Person.name\":\"Anderl‐Straub, Sarah\"},{\"Person.name\":\"Andersson, Christin\"},{\"Person.name\":\"Antonell, Anna\"},{\"Person.name\":\"Archetti, Silvana\"},{\"Person.name\":\"Arighi, Andrea\"},{\"Person.name\":\"Balasa, Mircea\"},{\"Person.name\":\"Barandiaran, Myriam\"},{\"Person.name\":\"Bargalló, Nuria\"},{\"Person.name\":\"Bartha, Robart\"},{\"Person.name\":\"Bender, Benjamin\"},{\"Person.name\":\"Benussi, Luisa\"},{\"Person.name\":\"Bessi, Valentina\"},{\"Person.name\":\"Binetti, Giuliano\"},{\"Person.name\":\"Black, Sandra\"},{\"Person.name\":\"Bocchetta, Martina\"},{\"Person.name\":\"Borrego‐Ecija, Sergi\"},{\"Person.name\":\"Bras, Jose\"},{\"Person.name\":\"Bruffaerts, Rose\"},{\"Person.name\":\"Caroppo, Paola\"},{\"Person.name\":\"Cash, David\"},{\"Person.name\":\"Castelo-Branco, Miguel\",\"Person.identifier.orcid\":\"0000-0003-4364-6373\"},{\"Person.name\":\"Convery, Rhian\"},{\"Person.name\":\"Cope, Thomas\"},{\"Person.name\":\"Cosseddu, Maura\"},{\"Person.name\":\"de Arriba, María\"},{\"Person.name\":\"Di Fede, Giuseppe\"},{\"Person.name\":\"Díaz, Zigor\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Tsvetanov, Kamen A. Gazzina, Stefano Jones, P. Simon Swieten, John Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Moore, Katrina M Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Panman, Jessica Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Papma, Janne Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans‐Otto Institutet, Karolinska Keren, Ron Langheinrich, Tobias Leitão, Maria João Lladó, Albert Lombardi, Gemma Piaceri, Irene Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Pievani, Michela Olives, Jaume Padovani, Alessandro Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Masellis, Mario Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa‐Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Tartaglia, Maria Carmela Shafei, Rachelle Shoesmith, Christen Tábuas‐Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang‐Wai, David Thomas, David L Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Finger, Elizabeth Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Vandenberghe, Rik Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Ghidoni, Roberta Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl‐Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego‐Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-04-06T16:59:34Z |
| datacite.date.embargoed.fl_str_mv | 2021-04-06T16:59:34Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
| datacite.titles.title.fl_str_mv | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Tsvetanov, Kamen A. Gazzina, Stefano Jones, P. Simon Swieten, John Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Moore, Katrina M Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Panman, Jessica Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Papma, Janne Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans‐Otto Institutet, Karolinska Keren, Ron Langheinrich, Tobias Leitão, Maria João Lladó, Albert Lombardi, Gemma Piaceri, Irene Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Pievani, Michela Olives, Jaume Padovani, Alessandro Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Masellis, Mario Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa‐Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Tartaglia, Maria Carmela Shafei, Rachelle Shoesmith, Christen Tábuas‐Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang‐Wai, David Thomas, David L Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Finger, Elizabeth Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Vandenberghe, Rik Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Ghidoni, Roberta Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl‐Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego‐Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-04-06T16:59:34Z |
| dc.date.embargoed.fl_str_mv | 2021-04-06T16:59:34Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/47260 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | John Wiley & Sons, Inc. |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
| dc.title.fl_str_mv | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial frontotemporal dementia (FTD). Methods: We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data-driven approach to link cognitive performance with both structural and functional magnetic resonance imaging. Atrophy and brain network connectivity were compared between groups, in relation to the time from expected symptom onset. Results: There were group differences in brain structure and function, in the absence of differences in cognitive performance. Specifically, we identified behaviorally relevant structural and functional network differences. Structure-function relationships were similar in both groups, but coupling between functional connectivity and cognition was stronger for carriers than for non-carriers, and increased with proximity to the expected onset of disease. Discussion: Our findings suggest that the maintenance of functional network connectivity enables carriers to maintain cognitive performance. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/9281d2d9-aff0-4f85-862a-6a53bc544480/download |
| id | ul_aad9ee7a166325d730a3e07c721cf1cb |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/47260 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/47260 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Tsvetanov, Kamen A. Gazzina, Stefano Jones, P. Simon Swieten, John Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Moore, Katrina M Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Panman, Jessica Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Papma, Janne Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans‐Otto Institutet, Karolinska Keren, Ron Langheinrich, Tobias Leitão, Maria João Lladó, Albert Lombardi, Gemma Piaceri, Irene Loosli, Sandra Maruta, Carolina Maruta, Carolina https://www.ciencia-id.pt/4B1D-5F59-6221 4B1D-5F59-6221 http://orcid.org/0000-0003-3359-379X 0000-0003-3359-379X Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel Miltenberger-Miltenyi, Gabriel https://www.ciencia-id.pt/AE16-3A8D-0392 AE16-3A8D-0392 http://orcid.org/0000-0003-0224-1281 0000-0003-0224-1281 van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Pievani, Michela Olives, Jaume Padovani, Alessandro Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Masellis, Mario Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa‐Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Tartaglia, Maria Carmela Shafei, Rachelle Shoesmith, Christen Tábuas‐Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang‐Wai, David Thomas, David L Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Finger, Elizabeth Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Verdelho, Ana https://www.ciencia-id.pt/FC14-938F-EBBD FC14-938F-EBBD http://orcid.org/0000-0003-4945-4946 0000-0003-4945-4946 Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Vandenberghe, Rik Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre De Mendonça, Alexandre https://www.ciencia-id.pt/1615-41B4-0848 1615-41B4-0848 http://orcid.org/0000-0002-0488-1453 0000-0002-0488-1453 Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Ghidoni, Roberta Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl‐Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego‐Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Castelo-Branco, Miguel https://www.ciencia-id.pt/7A12-48FE-7B56 7A12-48FE-7B56 http://orcid.org/0000-0003-4364-6373 0000-0003-4364-6373 Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor |
| publishDate | 2020 |
| publisher.none.fl_str_mv | John Wiley & Sons, Inc. |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engJohn Wiley & Sons, Inc.pt_PTIntroduction: The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial frontotemporal dementia (FTD). Methods: We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data-driven approach to link cognitive performance with both structural and functional magnetic resonance imaging. Atrophy and brain network connectivity were compared between groups, in relation to the time from expected symptom onset. Results: There were group differences in brain structure and function, in the absence of differences in cognitive performance. Specifically, we identified behaviorally relevant structural and functional network differences. Structure-function relationships were similar in both groups, but coupling between functional connectivity and cognition was stronger for carriers than for non-carriers, and increased with proximity to the expected onset of disease. Discussion: Our findings suggest that the maintenance of functional network connectivity enables carriers to maintain cognitive performance.application/pdfpt_PTBrain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementiaTsvetanov, Kamen A.Gazzina, StefanoJones, P. SimonSwieten, JohnBorroni, BarbaraSanchez‐Valle, RaquelMoreno, FerminLaforce, RobertGraff, CarolineSynofzik, MatthisGalimberti, DanielaMoore, Katrina MDuro, DianaFenoglio, ChiaraFerrari, CamillaFerreira, CarlosFerreira, Catarina B.Flanagan, TobyFox, NickFreedman, MorrisFumagalli, GiorgioPanman, JessicaGabilondo, AlazneGasparotti, RobertoGauthier, SergeGazzina, StefanoGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasPapma, JanneIndakoetxea, BegoñaJelic, VesnaJiskoot, LizeKarnath, Hans‐OttoInstitutet, KarolinskaKeren, RonLangheinrich, TobiasLeitão, Maria JoãoLladó, AlbertLombardi, GemmaPiaceri, IreneLoosli, SandraPersonalMaruta, CarolinaDSpacehttp://dspace.org/items/4a8bdaf9-480a-4836-ac4b-c80c3b4e0391DSpacehttp://dspace.org/items/4a8bdaf9-480a-4836-ac4b-c80c3b4e0391MarutaCarolinaCiência IDhttps://www.ciencia-id.pt4B1D-5F59-6221ORCIDhttp://orcid.org0000-0003-3359-379XScopus Author IDhttps://www.scopus.com35327513800Mead, SimonMeeter, LiekePersonalMiltenberger-Miltenyi, GabrielDSpacehttp://dspace.org/items/58c7f5b7-9f9d-42b6-9b39-c53dd40a79c7DSpacehttp://dspace.org/items/58c7f5b7-9f9d-42b6-9b39-c53dd40a79c7Miltenberger-MiltenyiGabrielCiência IDhttps://www.ciencia-id.ptAE16-3A8D-0392ORCIDhttp://orcid.org0000-0003-0224-1281van Minkelen, RickMitchell, SaraNacmias, BenedettaNeason, MollieNicholas, JenniferPievani, MichelaOlives, JaumePadovani, AlessandroPijnenburg, YolandePolito, CristinaPremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaMasellis, MarioRedaelli, VeronicaRittman, TimRogaeva, EkaterinaRosa‐Neto, PedroRossi, GiacominaRossor, MartinSantiago, BeatrizScarpini, ElioSchönecker, SonjaSemler, ElisaTartaglia, Maria CarmelaShafei, RachelleShoesmith, ChristenTábuas‐Pereira, MiguelTainta, MikelTaipa, RicardoTang‐Wai, DavidThomas, David LThompson, PaulThonberg, HakanTimberlake, CarolynFinger, ElizabethTiraboschi, PietroVandamme, PhilipVandenbulcke, MathieuVeldsman, MichelePersonalVerdelho, AnaDSpacehttp://dspace.org/items/11ec545d-3044-4ffd-b658-578d00f82d2aDSpacehttp://dspace.org/items/11ec545d-3044-4ffd-b658-578d00f82d2aVerdelhoAnaCiência IDhttps://www.ciencia-id.ptFC14-938F-EBBDORCIDhttp://orcid.org0000-0003-4945-4946Scopus Author IDhttps://www.scopus.com6602902026Villanua, JorgeWarren, JasonWilke, CarloWoollacott, IoneWlasich, ElisabethVandenberghe, RikZetterberg, HenrikZulaica, MirenPersonalDe Mendonça, AlexandreDSpacehttp://dspace.org/items/53ca3547-99ce-4b68-9330-7879a54c47b7DSpacehttp://dspace.org/items/53ca3547-99ce-4b68-9330-7879a54c47b7de MendonçaAlexandreCiência IDhttps://www.ciencia-id.pt1615-41B4-0848ORCIDhttp://orcid.org0000-0002-0488-1453Scopus Author IDhttps://www.scopus.com7003320823Scopus Author IDhttps://www.scopus.com55307490700Tagliavini, FabrizioSantana, IsabelDucharme, SimonButler, ChrisGerhard, AlexanderDanek, AdrianLevin, JohannesOtto, MarkusFrisoni, GiovanniGhidoni, RobertaSorbi, SandroRohrer, Jonathan D.Rowe, James B.Afonso, SóniaAlmeida, Maria RosarioAnderl‐Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, LuisaBessi, ValentinaBinetti, GiulianoBlack, SandraBocchetta, MartinaBorrego‐Ecija, SergiBras, JoseBruffaerts, RoseCaroppo, PaolaCash, DavidPersonalCastelo-Branco, MiguelDSpacehttp://dspace.org/items/16245106-f8db-49a9-be95-8806aa05dfadDSpacehttp://dspace.org/items/16245106-f8db-49a9-be95-8806aa05dfadCastelo-BrancoMiguelCiência IDhttps://www.ciencia-id.pt7A12-48FE-7B56ORCIDhttp://orcid.org0000-0003-4364-6373Researcher IDhttps://www.researcherid.comF-3866-2019Scopus Author IDhttps://www.scopus.com6701423628Scopus Author IDhttps://www.scopus.com56677497800Scopus Author IDhttps://www.scopus.com57210406494Convery, RhianCope, ThomasCosseddu, Maurade Arriba, MaríaDi Fede, GiuseppeDíaz, ZigorHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf1552-5260DOIIsPartOf10.1002/alz.122092021-04-06T16:59:34Z20202020-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/47260http://purl.org/coar/access_right/c_abf2open accessFrontotemporal dementia (FTD)Functional magnetic resonance imaging (fMRI)Network connectivityPresymptomatic5576639 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/9281d2d9-aff0-4f85-862a-6a53bc544480/downloadAlzheimer's & Dementia173500514 |
| spellingShingle | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia Tsvetanov, Kamen A. Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
| status | SINGLETON |
| subject.fl_str_mv | Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
| title | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
| title_full | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
| title_fullStr | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
| title_full_unstemmed | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
| title_short | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
| title_sort | Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
| topic | Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
| topic_facet | Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
| url | http://hdl.handle.net/10451/47260 |
| visible | 1 |