Publicação
A unified nomenclature and amino acid numbering for human PTEN
| Resumo: | The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN. |
|---|---|
| Autores principais: | Pulido, Rafael |
| Outros Autores: | Baker, Suzanne J.; Barata, João T.; Carracedo, Arkaitz; Cid, Victor J.; Chin-Sang, Ian D.; Davé, Vrushank; den Hertog, Jeroen; Devreotes, Peter; Eickholt, Britta J.; Eng, Charis; Furnari, Frank B.; Georgescu, Maria-Magdalena; Gericke, Arne; Hopkins, Benjamin; Jiang, Xeujun; Lee, Seung-Rock; Lösche, Mathias; Malaney, Prerna; Matias-Guiu, Xavier; Molina, María; Pandolfi, Pier Paolo; Parsons, Ramon; Pinton, Paolo; Rivas, Carmen; Rocha, Rafael M.; Rodríguez, Manuel S.; Ross, Alonzo H.; Serrano, Manuel; Stambolic, Vuk; Stiles, Bangyan; Suzuki, Akira; Tan, Seong-Seng; Tonks, Nicholas K.; Trotman, Lloyd C.; Wolff, Nicolas; Woscholski, Rudiger; Wu, Hong; Leslie, Nicholas R. |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866808912453304320 |
|---|---|
| author | Pulido, Rafael |
| author2 | Baker, Suzanne J. Barata, João T. Carracedo, Arkaitz Cid, Victor J. Chin-Sang, Ian D. Davé, Vrushank den Hertog, Jeroen Devreotes, Peter Eickholt, Britta J. Eng, Charis Furnari, Frank B. Georgescu, Maria-Magdalena Gericke, Arne Hopkins, Benjamin Jiang, Xeujun Lee, Seung-Rock Lösche, Mathias Malaney, Prerna Matias-Guiu, Xavier Molina, María Pandolfi, Pier Paolo Parsons, Ramon Pinton, Paolo Rivas, Carmen Rocha, Rafael M. Rodríguez, Manuel S. Ross, Alonzo H. Serrano, Manuel Stambolic, Vuk Stiles, Bangyan Suzuki, Akira Tan, Seong-Seng Tonks, Nicholas K. Trotman, Lloyd C. Wolff, Nicolas Woscholski, Rudiger Wu, Hong Leslie, Nicholas R. |
| author2_role | author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Pulido, Rafael Baker, Suzanne J. Barata, João T. Carracedo, Arkaitz Cid, Victor J. Chin-Sang, Ian D. Davé, Vrushank den Hertog, Jeroen Devreotes, Peter Eickholt, Britta J. Eng, Charis Furnari, Frank B. Georgescu, Maria-Magdalena Gericke, Arne Hopkins, Benjamin Jiang, Xeujun Lee, Seung-Rock Lösche, Mathias Malaney, Prerna Matias-Guiu, Xavier Molina, María Pandolfi, Pier Paolo Parsons, Ramon Pinton, Paolo Rivas, Carmen Rocha, Rafael M. Rodríguez, Manuel S. Ross, Alonzo H. Serrano, Manuel Stambolic, Vuk Stiles, Bangyan Suzuki, Akira Tan, Seong-Seng Tonks, Nicholas K. Trotman, Lloyd C. Wolff, Nicolas Woscholski, Rudiger Wu, Hong Leslie, Nicholas R. |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pulido, Rafael\"},{\"Person.name\":\"Baker, Suzanne J.\"},{\"Person.name\":\"Barata, João T.\",\"Person.identifier.orcid\":\"0000-0002-4826-8976\"},{\"Person.name\":\"Carracedo, Arkaitz\"},{\"Person.name\":\"Cid, Victor J.\"},{\"Person.name\":\"Chin-Sang, Ian D.\"},{\"Person.name\":\"Davé, Vrushank\"},{\"Person.name\":\"den Hertog, Jeroen\"},{\"Person.name\":\"Devreotes, Peter\"},{\"Person.name\":\"Eickholt, Britta J.\"},{\"Person.name\":\"Eng, Charis\"},{\"Person.name\":\"Furnari, Frank B.\"},{\"Person.name\":\"Georgescu, Maria-Magdalena\"},{\"Person.name\":\"Gericke, Arne\"},{\"Person.name\":\"Hopkins, Benjamin\"},{\"Person.name\":\"Jiang, Xeujun\"},{\"Person.name\":\"Lee, Seung-Rock\"},{\"Person.name\":\"Lösche, Mathias\"},{\"Person.name\":\"Malaney, Prerna\"},{\"Person.name\":\"Matias-Guiu, Xavier\"},{\"Person.name\":\"Molina, María\"},{\"Person.name\":\"Pandolfi, Pier Paolo\"},{\"Person.name\":\"Parsons, Ramon\"},{\"Person.name\":\"Pinton, Paolo\"},{\"Person.name\":\"Rivas, Carmen\"},{\"Person.name\":\"Rocha, Rafael M.\"},{\"Person.name\":\"Rodríguez, Manuel S.\"},{\"Person.name\":\"Ross, Alonzo H.\"},{\"Person.name\":\"Serrano, Manuel\"},{\"Person.name\":\"Stambolic, Vuk\"},{\"Person.name\":\"Stiles, Bangyan\"},{\"Person.name\":\"Suzuki, Akira\"},{\"Person.name\":\"Tan, Seong-Seng\"},{\"Person.name\":\"Tonks, Nicholas K.\"},{\"Person.name\":\"Trotman, Lloyd C.\"},{\"Person.name\":\"Wolff, Nicolas\"},{\"Person.name\":\"Woscholski, Rudiger\"},{\"Person.name\":\"Wu, Hong\"},{\"Person.name\":\"Leslie, Nicholas R.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Pulido, Rafael Baker, Suzanne J. Barata, João T. Carracedo, Arkaitz Cid, Victor J. Chin-Sang, Ian D. Davé, Vrushank den Hertog, Jeroen Devreotes, Peter Eickholt, Britta J. Eng, Charis Furnari, Frank B. Georgescu, Maria-Magdalena Gericke, Arne Hopkins, Benjamin Jiang, Xeujun Lee, Seung-Rock Lösche, Mathias Malaney, Prerna Matias-Guiu, Xavier Molina, María Pandolfi, Pier Paolo Parsons, Ramon Pinton, Paolo Rivas, Carmen Rocha, Rafael M. Rodríguez, Manuel S. Ross, Alonzo H. Serrano, Manuel Stambolic, Vuk Stiles, Bangyan Suzuki, Akira Tan, Seong-Seng Tonks, Nicholas K. Trotman, Lloyd C. Wolff, Nicolas Woscholski, Rudiger Wu, Hong Leslie, Nicholas R. |
| datacite.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-02-17T15:57:45Z |
| datacite.date.embargoed.fl_str_mv | 2022-02-17T15:57:45Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.titles.title.fl_str_mv | A unified nomenclature and amino acid numbering for human PTEN |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Pulido, Rafael Baker, Suzanne J. Barata, João T. Carracedo, Arkaitz Cid, Victor J. Chin-Sang, Ian D. Davé, Vrushank den Hertog, Jeroen Devreotes, Peter Eickholt, Britta J. Eng, Charis Furnari, Frank B. Georgescu, Maria-Magdalena Gericke, Arne Hopkins, Benjamin Jiang, Xeujun Lee, Seung-Rock Lösche, Mathias Malaney, Prerna Matias-Guiu, Xavier Molina, María Pandolfi, Pier Paolo Parsons, Ramon Pinton, Paolo Rivas, Carmen Rocha, Rafael M. Rodríguez, Manuel S. Ross, Alonzo H. Serrano, Manuel Stambolic, Vuk Stiles, Bangyan Suzuki, Akira Tan, Seong-Seng Tonks, Nicholas K. Trotman, Lloyd C. Wolff, Nicolas Woscholski, Rudiger Wu, Hong Leslie, Nicholas R. |
| dc.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-02-17T15:57:45Z |
| dc.date.embargoed.fl_str_mv | 2022-02-17T15:57:45Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/51385 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | American Association for the Advancement of Science |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.title.fl_str_mv | A unified nomenclature and amino acid numbering for human PTEN |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/067d5efb-bfd7-4a4d-85b0-d9ff6ed93f21/download |
| id | ul_aae8c04dfdaf216d2b0f9ade9bcd08af |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/51385 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/51385 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Pulido, Rafael Baker, Suzanne J. Barata, João T. Barata, João T. http://orcid.org/0000-0002-4826-8976 0000-0002-4826-8976 Carracedo, Arkaitz Cid, Victor J. Chin-Sang, Ian D. Davé, Vrushank den Hertog, Jeroen Devreotes, Peter Eickholt, Britta J. Eng, Charis Furnari, Frank B. Georgescu, Maria-Magdalena Gericke, Arne Hopkins, Benjamin Jiang, Xeujun Lee, Seung-Rock Lösche, Mathias Malaney, Prerna Matias-Guiu, Xavier Molina, María Pandolfi, Pier Paolo Parsons, Ramon Pinton, Paolo Rivas, Carmen Rocha, Rafael M. Rodríguez, Manuel S. Ross, Alonzo H. Serrano, Manuel Stambolic, Vuk Stiles, Bangyan Suzuki, Akira Tan, Seong-Seng Tonks, Nicholas K. Trotman, Lloyd C. Wolff, Nicolas Woscholski, Rudiger Wu, Hong Leslie, Nicholas R. |
| publishDate | 2014 |
| publisher.none.fl_str_mv | American Association for the Advancement of Science |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engAmerican Association for the Advancement of Sciencept_PTThe tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.application/pdfpt_PTA unified nomenclature and amino acid numbering for human PTENPulido, RafaelBaker, Suzanne J.PersonalBarata, João T.DSpacehttp://dspace.org/items/06f27f7f-1c6c-4c03-a70d-52f8a388bd3bDSpacehttp://dspace.org/items/06f27f7f-1c6c-4c03-a70d-52f8a388bd3bBarataJoãoORCIDhttp://orcid.org0000-0002-4826-8976Researcher IDhttps://www.researcherid.comD-9181-2015Scopus Author IDhttps://www.scopus.com7006937224Carracedo, ArkaitzCid, Victor J.Chin-Sang, Ian D.Davé, Vrushankden Hertog, JeroenDevreotes, PeterEickholt, Britta J.Eng, CharisFurnari, Frank B.Georgescu, Maria-MagdalenaGericke, ArneHopkins, BenjaminJiang, XeujunLee, Seung-RockLösche, MathiasMalaney, PrernaMatias-Guiu, XavierMolina, MaríaPandolfi, Pier PaoloParsons, RamonPinton, PaoloRivas, CarmenRocha, Rafael M.Rodríguez, Manuel S.Ross, Alonzo H.Serrano, ManuelStambolic, VukStiles, BangyanSuzuki, AkiraTan, Seong-SengTonks, Nicholas K.Trotman, Lloyd C.Wolff, NicolasWoscholski, RudigerWu, HongLeslie, Nicholas R.HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf1945-0877DOIIsPartOf10.1126/scisignal.20055602022-02-17T15:57:45Z20142014-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/51385http://purl.org/coar/access_right/c_16ecrestricted access485455 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/067d5efb-bfd7-4a4d-85b0-d9ff6ed93f21/downloadScience Signaling7332 |
| spellingShingle | A unified nomenclature and amino acid numbering for human PTEN Pulido, Rafael |
| status | SINGLETON |
| title | A unified nomenclature and amino acid numbering for human PTEN |
| title_full | A unified nomenclature and amino acid numbering for human PTEN |
| title_fullStr | A unified nomenclature and amino acid numbering for human PTEN |
| title_full_unstemmed | A unified nomenclature and amino acid numbering for human PTEN |
| title_short | A unified nomenclature and amino acid numbering for human PTEN |
| title_sort | A unified nomenclature and amino acid numbering for human PTEN |
| url | http://hdl.handle.net/10451/51385 |
| visible | 1 |