Publicação
Associação de infecção por Streptococcus Bovis e o carcinoma colorrectal
| Resumo: | Streptococcus bovis infection, mainly infectious endocarditis, has been associated with colorectal carcinoma. Recently it has been discovered that this is a bacteria complex that includes various species, like Streptococcus gallolyticus, previously called S. bovis biotype I, the most strongly associated with colorectal carcinoma. S gallolyticus cannot colonize normal colonic mucosa, but in the presence of pre-neoplastic lesions (polyps and adenomas) it can adhere and, through paracellular translocation and immune cell survival, reach the systemic circulation, which allows it to then colonize lesions rich in collagen type I and IV, like damaged cardiac valves, developing infectious endocarditis. It also has a role on carcinogenesis by transforming adenomas into carcinomas through induction of an inflammatory reaction (rise in the levels of NF-ĸB mRNA and IL-8 mRNA). The detection of antibodies against some antigens of this bacteria has been claimed to be a promising screening test for colorectal carcinoma in high risk population, with sensibility of 68% and 78% for colorectal carcinoma and adenoma, respectively, and specificity of 83,33%. |
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| Autores principais: | Carreto, Luís Miguel de Matos |
| Assunto: | Infecção por Streptococcus bovis Carcinoma colorrectal Gastroenterologia |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | português |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Streptococcus bovis infection, mainly infectious endocarditis, has been associated with colorectal carcinoma. Recently it has been discovered that this is a bacteria complex that includes various species, like Streptococcus gallolyticus, previously called S. bovis biotype I, the most strongly associated with colorectal carcinoma. S gallolyticus cannot colonize normal colonic mucosa, but in the presence of pre-neoplastic lesions (polyps and adenomas) it can adhere and, through paracellular translocation and immune cell survival, reach the systemic circulation, which allows it to then colonize lesions rich in collagen type I and IV, like damaged cardiac valves, developing infectious endocarditis. It also has a role on carcinogenesis by transforming adenomas into carcinomas through induction of an inflammatory reaction (rise in the levels of NF-ĸB mRNA and IL-8 mRNA). The detection of antibodies against some antigens of this bacteria has been claimed to be a promising screening test for colorectal carcinoma in high risk population, with sensibility of 68% and 78% for colorectal carcinoma and adenoma, respectively, and specificity of 83,33%. |
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