Publicação
Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance
| Resumo: | There is limited information on the serotypes causing non-invasive pneumococcal pneumonia (NIPP). Our aim was to characterize pneumococci causing NIPP in adults to determine recent changes in serotype prevalence, the potential coverage of pneumococcal vaccines and changes in antimicrobial resistance. Serotypes and antimicrobial susceptibility profiles of a sample of 1300 isolates recovered from adult patients (≥18 yrs) between 1999 and 2011 (13 years) were determined. Serotype 3 was the most frequent cause of NIPP accounting for 18% of the isolates. The other most common serotypes were 11A (7%), 19F (7%), 19A (5%), 14 (4%), 22F (4%), 23F (4%) and 9N (4%). Between 1999 and 2011, there were significant changes in the proportion of isolates expressing vaccine serotypes, with a steady decline of the serotypes included in the 7-valent conjugate vaccine from 31% (1999-2003) to 11% (2011) (P<0.001). Taking together the most recent study years (2009-2011), the potential coverage of the 13-valent conjugate vaccine was 44% and of the 23-valent polysaccharide vaccine was 66%. While erythromycin resistance increased from 8% in 1999-2003 to 18% in 2011 (P<0.001), no significant trend was identified for penicillin non-susceptibility, which had an average value of 18.5%. The serotype distribution found in this study for NIPP was very different from the one previously described for IPD, with only two serotypes in common to the ones responsible for half of each presentation in 2009-2011 - serotypes 3 and 19A. In spite of these differences, the overall prevalence of resistant isolates was similar in NIPP and in IPD. |
|---|---|
| Autores principais: | Horácio, Andreia |
| Outros Autores: | Lopes, Joana P.; Ramirez, Mário; Melo Cristino, José |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866810472535162880 |
|---|---|
| author | Horácio, Andreia |
| author2 | Lopes, Joana P. Ramirez, Mário Melo Cristino, José |
| author2_role | author author author |
| author_facet | Horácio, Andreia Lopes, Joana P. Ramirez, Mário Melo Cristino, José |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Horácio, Andreia\"},{\"Person.name\":\"Lopes, Joana P.\"},{\"Person.name\":\"Ramirez, Mário\",\"Person.identifier.orcid\":\"0000-0002-4084-6233\"},{\"Person.name\":\"Melo Cristino, José\",\"Person.identifier.orcid\":\"0000-0001-8643-1722\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Horácio, Andreia Lopes, Joana P. Ramirez, Mário Melo Cristino, José |
| datacite.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-07-22T15:09:55Z |
| datacite.date.embargoed.fl_str_mv | 2021-07-22T15:09:55Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.titles.title.fl_str_mv | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Horácio, Andreia Lopes, Joana P. Ramirez, Mário Melo Cristino, José |
| dc.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-07-22T15:09:55Z |
| dc.date.embargoed.fl_str_mv | 2021-07-22T15:09:55Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/49060 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Frontiers |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.title.fl_str_mv | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | There is limited information on the serotypes causing non-invasive pneumococcal pneumonia (NIPP). Our aim was to characterize pneumococci causing NIPP in adults to determine recent changes in serotype prevalence, the potential coverage of pneumococcal vaccines and changes in antimicrobial resistance. Serotypes and antimicrobial susceptibility profiles of a sample of 1300 isolates recovered from adult patients (≥18 yrs) between 1999 and 2011 (13 years) were determined. Serotype 3 was the most frequent cause of NIPP accounting for 18% of the isolates. The other most common serotypes were 11A (7%), 19F (7%), 19A (5%), 14 (4%), 22F (4%), 23F (4%) and 9N (4%). Between 1999 and 2011, there were significant changes in the proportion of isolates expressing vaccine serotypes, with a steady decline of the serotypes included in the 7-valent conjugate vaccine from 31% (1999-2003) to 11% (2011) (P<0.001). Taking together the most recent study years (2009-2011), the potential coverage of the 13-valent conjugate vaccine was 44% and of the 23-valent polysaccharide vaccine was 66%. While erythromycin resistance increased from 8% in 1999-2003 to 18% in 2011 (P<0.001), no significant trend was identified for penicillin non-susceptibility, which had an average value of 18.5%. The serotype distribution found in this study for NIPP was very different from the one previously described for IPD, with only two serotypes in common to the ones responsible for half of each presentation in 2009-2011 - serotypes 3 and 19A. In spite of these differences, the overall prevalence of resistant isolates was similar in NIPP and in IPD. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/460eb204-7402-4aaf-bc8d-447adee675a2/download |
| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | OE 3599-PPCDT |
| id | ul_bc82e207c67fd3d3b8e863dca8e2cbe7 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/49060 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/49060 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Horácio, Andreia Lopes, Joana P. Ramirez, Mário Ramirez, Mário https://www.ciencia-id.pt/9C1C-F2A2-4226 9C1C-F2A2-4226 http://orcid.org/0000-0002-4084-6233 0000-0002-4084-6233 Melo Cristino, José Melo Cristino, José https://www.ciencia-id.pt/871E-6AD6-F37C 871E-6AD6-F37C http://orcid.org/0000-0001-8643-1722 0000-0001-8643-1722 |
| publishDate | 2014 |
| publisher.none.fl_str_mv | Frontiers |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engFrontierspt_PTThere is limited information on the serotypes causing non-invasive pneumococcal pneumonia (NIPP). Our aim was to characterize pneumococci causing NIPP in adults to determine recent changes in serotype prevalence, the potential coverage of pneumococcal vaccines and changes in antimicrobial resistance. Serotypes and antimicrobial susceptibility profiles of a sample of 1300 isolates recovered from adult patients (≥18 yrs) between 1999 and 2011 (13 years) were determined. Serotype 3 was the most frequent cause of NIPP accounting for 18% of the isolates. The other most common serotypes were 11A (7%), 19F (7%), 19A (5%), 14 (4%), 22F (4%), 23F (4%) and 9N (4%). Between 1999 and 2011, there were significant changes in the proportion of isolates expressing vaccine serotypes, with a steady decline of the serotypes included in the 7-valent conjugate vaccine from 31% (1999-2003) to 11% (2011) (P<0.001). Taking together the most recent study years (2009-2011), the potential coverage of the 13-valent conjugate vaccine was 44% and of the 23-valent polysaccharide vaccine was 66%. While erythromycin resistance increased from 8% in 1999-2003 to 18% in 2011 (P<0.001), no significant trend was identified for penicillin non-susceptibility, which had an average value of 18.5%. The serotype distribution found in this study for NIPP was very different from the one previously described for IPD, with only two serotypes in common to the ones responsible for half of each presentation in 2009-2011 - serotypes 3 and 19A. In spite of these differences, the overall prevalence of resistant isolates was similar in NIPP and in IPD.application/pdfpt_PTNon-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistanceHorácio, AndreiaLopes, Joana P.PersonalRamirez, MárioDSpacehttp://dspace.org/items/4fd54543-2f86-41cd-aafa-bc6e6501471dDSpacehttp://dspace.org/items/4fd54543-2f86-41cd-aafa-bc6e6501471dRamos de Almeida RamirezMário NunoCiência IDhttps://www.ciencia-id.pt9C1C-F2A2-4226ORCIDhttp://orcid.org0000-0002-4084-6233Scopus Author IDhttps://www.scopus.com7201568476PersonalMelo Cristino, JoséDSpacehttp://dspace.org/items/acefbfd7-46d0-4429-80b1-ad159fe4ca95DSpacehttp://dspace.org/items/acefbfd7-46d0-4429-80b1-ad159fe4ca95Melo CristinoJoséCiência IDhttps://www.ciencia-id.pt871E-6AD6-F37CORCIDhttp://orcid.org0000-0001-8643-1722Researcher IDhttps://www.researcherid.comH-3726-2013Scopus Author IDhttps://www.scopus.com7004053640HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf1932-6203DOIIsPartOf10.1371/journal.pone.01030922021-07-22T15:09:55Z20142014-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/49060http://purl.org/coar/access_right/c_abf2open access762232 bytesFundação para a Ciência e a TecnologiaCHANGING PNEUMOCOCCAL POPULATION IN ADULTS AS A CONSEQUENCE OF DIFFERENT VACCINATION STRATEGIESOECrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaBesieged by conjugate vaccination: changes in the pneumococcal population and their genomic consequences3599-PPCDTCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2014http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/460eb204-7402-4aaf-bc8d-447adee675a2/downloadPLoS ONE97 |
| spellingShingle | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance Horácio, Andreia |
| status | SINGLETON |
| title | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance |
| title_full | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance |
| title_fullStr | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance |
| title_full_unstemmed | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance |
| title_short | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance |
| title_sort | Non-invasive Pneumococcal pneumonia in Portugal : serotype distribution and antimicrobial resistance |
| url | http://hdl.handle.net/10451/49060 |
| visible | 1 |