Publicação
Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction
| Resumo: | Aristotelia serrata, wineberry, or makomako, is a small deciduous fast-growing shrub of New Zealand that produces a berry. In this study leaf extracts were produced using ultra-sound technology. Alzheimer’s Disease is a progressive mental deterioration related with ageing and senility, in which approved drugs for treatment inhibit butyrylcholinesterase(BChE), an enzyme present in the human brain. The ultrasound assisted extraction of natural anti-butyrylcholinesterase and antioxidants from this plant, and the yield of extraction were optimized using response surface methodology. The effect of acoustic power density(0.13–0.65 W/mL), time (1–20 min), and ethanol concentration (20–80%) on BChE inhibition,antioxidant activity, and extraction yield was determined, the optimum extraction conditions being 0.53 W/mL, 17.12 min and 74% ethanol. The optimized extracts were produced to experimentally validate the predicted responses. The IC50 concentrations were experimentally determined (26.2 ug/mL for BChE, 5.5 ug/mL for radical scavenging activity). A. serrata leaf extracts have potential to be used as complements to medicines traditionally used for memory dysfunction |
|---|---|
| Autores principais: | Majid, Hafiz |
| Outros Autores: | Silva, Filipa V.M. |
| Assunto: | plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866809294175862784 |
|---|---|
| author | Majid, Hafiz |
| author2 | Silva, Filipa V.M. |
| author2_role | author |
| author_facet | Majid, Hafiz Silva, Filipa V.M. |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Majid, Hafiz\"},{\"Person.name\":\"Silva, Filipa V.M.\",\"Person.identifier.orcid\":\"0000-0003-4700-2938\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Majid, Hafiz Silva, Filipa V.M. |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-09-27T09:46:40Z |
| datacite.date.embargoed.fl_str_mv | 2021-09-27T09:46:40Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
| datacite.titles.title.fl_str_mv | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Majid, Hafiz Silva, Filipa V.M. |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-09-27T09:46:40Z |
| dc.date.embargoed.fl_str_mv | 2021-09-27T09:46:40Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.5/22015 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
| dc.title.fl_str_mv | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Aristotelia serrata, wineberry, or makomako, is a small deciduous fast-growing shrub of New Zealand that produces a berry. In this study leaf extracts were produced using ultra-sound technology. Alzheimer’s Disease is a progressive mental deterioration related with ageing and senility, in which approved drugs for treatment inhibit butyrylcholinesterase(BChE), an enzyme present in the human brain. The ultrasound assisted extraction of natural anti-butyrylcholinesterase and antioxidants from this plant, and the yield of extraction were optimized using response surface methodology. The effect of acoustic power density(0.13–0.65 W/mL), time (1–20 min), and ethanol concentration (20–80%) on BChE inhibition,antioxidant activity, and extraction yield was determined, the optimum extraction conditions being 0.53 W/mL, 17.12 min and 74% ethanol. The optimized extracts were produced to experimentally validate the predicted responses. The IC50 concentrations were experimentally determined (26.2 ug/mL for BChE, 5.5 ug/mL for radical scavenging activity). A. serrata leaf extracts have potential to be used as complements to medicines traditionally used for memory dysfunction |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/ccdedc22-26ee-4508-ace4-afa06fa8043d/download |
| id | ul_c8fc75fa10cec0783fd8cd2fd3cd3ca8 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.5/22015 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10400.5/22015 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Majid, Hafiz Silva, Filipa V.M. Silva, Filipa V.M. https://www.ciencia-id.pt/B610-66DA-A3AC B610-66DA-A3AC http://orcid.org/0000-0003-4700-2938 0000-0003-4700-2938 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engElsevierpt_PTAristotelia serrata, wineberry, or makomako, is a small deciduous fast-growing shrub of New Zealand that produces a berry. In this study leaf extracts were produced using ultra-sound technology. Alzheimer’s Disease is a progressive mental deterioration related with ageing and senility, in which approved drugs for treatment inhibit butyrylcholinesterase(BChE), an enzyme present in the human brain. The ultrasound assisted extraction of natural anti-butyrylcholinesterase and antioxidants from this plant, and the yield of extraction were optimized using response surface methodology. The effect of acoustic power density(0.13–0.65 W/mL), time (1–20 min), and ethanol concentration (20–80%) on BChE inhibition,antioxidant activity, and extraction yield was determined, the optimum extraction conditions being 0.53 W/mL, 17.12 min and 74% ethanol. The optimized extracts were produced to experimentally validate the predicted responses. The IC50 concentrations were experimentally determined (26.2 ug/mL for BChE, 5.5 ug/mL for radical scavenging activity). A. serrata leaf extracts have potential to be used as complements to medicines traditionally used for memory dysfunctionapplication/pdfpt_PTImprovement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extractionMajid, HafizPersonalSilva, Filipa V.M.DSpacehttp://dspace.org/items/c6da545d-92cd-4bee-9e4e-6a0afc4e71cdDSpacehttp://dspace.org/items/c6da545d-92cd-4bee-9e4e-6a0afc4e71cdVinagre Marques da Silva OliveiraMaria FilipaCiência IDhttps://www.ciencia-id.ptB610-66DA-A3ACORCIDhttp://orcid.org0000-0003-4700-2938Scopus Author IDhttps://www.scopus.com22942414000HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptDOIIsPartOfhttps://doi.org/10.1016/j.fbp.2020.10.0042021-09-27T09:46:40Z20202020-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.5/22015http://purl.org/coar/access_right/c_abf2open accessplant extractsultrasound extractionoptimizationyieldantioxidant activityAlzheimer’s Disease1394097 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/ccdedc22-26ee-4508-ace4-afa06fa8043d/downloadFood and Bioproducts Processing |
| spellingShingle | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction Majid, Hafiz plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
| status | SINGLETON |
| subject.fl_str_mv | plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
| title | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
| title_full | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
| title_fullStr | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
| title_full_unstemmed | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
| title_short | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
| title_sort | Improvement of butyrylcholinesterase enzymeinhibition and medicinal properties of extracts ofAristotelia serrata leaves by ultrasound extraction |
| topic | plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
| topic_facet | plant extracts ultrasound extraction optimization yield antioxidant activity Alzheimer’s Disease |
| url | http://hdl.handle.net/10400.5/22015 |
| visible | 1 |