Publicação
Relationships between inflammatory markers and suicide risk status in major depression
| Resumo: | Pro-inflammatory status has been implicated in depression and suicidal behaviors. Polyunsaturated fatty acids (PUFAs) and cytokines, two types of inflammatory biomarkers, have been associated with suicide, independent of depression severity. How these biomarkers relate to each other is less clear. We measured plasma phospholipid levels of arachidonic acid (AA%), docosahexaenoic acid (DHA%), and eicosapentaenoic acid (EPA%) as a percentage of total phospholipids, as well as serum interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), in 80 patients with major depressive disorder (MDD) and 24 healthy controls (HC). Individual PUFA and cytokine species were compared using ANOVA across four suicide risk-stratified groups: 1) highest-risk, recent (within 5 years) suicide attempters (n = 20); 2) high-risk, severe current suicidal ideators (having intent or plan) with no recent attempt history (n = 22); 3) low-risk, current non-ideators who were also lifetime non-attempters (n = 38); and 4) HC (n = 24). None of the participants were enrolled following an acute suicide attempt. Of biomarkers studied, only DHA% (p = 0.012) and IL-1β (p = 0.002) differed between groups. In post-hoc testing, DHA% was lower in attempters than ideators (p = 0.018) or MDD non-ideators (trend level, p = 0.073). IL-1β was lowest in attempters, differentiating them from ideators (p = 0.009) and HC (p = 0.004). Recent suicide attempt, one of the most powerful predictors of suicide risk, was also most closely tied to inflammatory indices in this study. Low DHA% as an indicator of suicide risk is consistent with previous reports; however, lower IL-1β was unexpected and may relate to acuity/chronicity of inflammation. There is a need for prospective studies of immune status with respect to suicidal behaviors. |
|---|---|
| Autores principais: | Ganança, Licínia |
| Outros Autores: | Galfalvy, Hanga C.; Cisneros-Trujillo, Sebastian; Basseda, Zahra; Cooper, Thomas B.; Ren, Xinguo; Figueira, Maria Luísa; Oquendo, Maria A.; Mann, J. John; Sublette, M. Elizabeth |
| Assunto: | Inflammation Cytokines Omega-3 polyunsaturated fatty acids (PUFA) Suicide Depression |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1865920838777176064 |
|---|---|
| author | Ganança, Licínia |
| author2 | Galfalvy, Hanga C. Cisneros-Trujillo, Sebastian Basseda, Zahra Cooper, Thomas B. Ren, Xinguo Figueira, Maria Luísa Oquendo, Maria A. Mann, J. John Sublette, M. Elizabeth |
| author2_role | author author author author author author author author author |
| author_facet | Ganança, Licínia Ganança, Licínia Galfalvy, Hanga C. Cisneros-Trujillo, Sebastian Basseda, Zahra Cooper, Thomas B. Ren, Xinguo Figueira, Maria Luísa Oquendo, Maria A. Mann, J. John Sublette, M. Elizabeth Galfalvy, Hanga C. Cisneros-Trujillo, Sebastian Basseda, Zahra Cooper, Thomas B. Ren, Xinguo Figueira, Maria Luísa Oquendo, Maria A. Mann, J. John Sublette, M. Elizabeth |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Ganança, Licínia\"},{\"Person.name\":\"Galfalvy, Hanga C.\"},{\"Person.name\":\"Cisneros-Trujillo, Sebastian\"},{\"Person.name\":\"Basseda, Zahra\"},{\"Person.name\":\"Cooper, Thomas B.\"},{\"Person.name\":\"Ren, Xinguo\"},{\"Person.name\":\"Figueira, Maria Luísa\",\"Person.identifier.orcid\":\"0000-0002-7921-5375\"},{\"Person.name\":\"Oquendo, Maria A.\"},{\"Person.name\":\"Mann, J. John\"},{\"Person.name\":\"Sublette, M. Elizabeth\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Ganança, Licínia Galfalvy, Hanga C. Cisneros-Trujillo, Sebastian Basseda, Zahra Cooper, Thomas B. Ren, Xinguo Figueira, Maria Luísa Oquendo, Maria A. Mann, J. John Sublette, M. Elizabeth |
| datacite.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-01-29T17:20:10Z |
| datacite.date.embargoed.fl_str_mv | 2021-01-29T17:20:10Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Inflammation Cytokines Omega-3 polyunsaturated fatty acids (PUFA) Suicide Depression |
| datacite.titles.title.fl_str_mv | Relationships between inflammatory markers and suicide risk status in major depression |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Ganança, Licínia Galfalvy, Hanga C. Cisneros-Trujillo, Sebastian Basseda, Zahra Cooper, Thomas B. Ren, Xinguo Figueira, Maria Luísa Oquendo, Maria A. Mann, J. John Sublette, M. Elizabeth |
| dc.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-01-29T17:20:10Z |
| dc.date.embargoed.fl_str_mv | 2021-01-29T17:20:10Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/45998 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Inflammation Cytokines Omega-3 polyunsaturated fatty acids (PUFA) Suicide Depression |
| dc.title.fl_str_mv | Relationships between inflammatory markers and suicide risk status in major depression |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Pro-inflammatory status has been implicated in depression and suicidal behaviors. Polyunsaturated fatty acids (PUFAs) and cytokines, two types of inflammatory biomarkers, have been associated with suicide, independent of depression severity. How these biomarkers relate to each other is less clear. We measured plasma phospholipid levels of arachidonic acid (AA%), docosahexaenoic acid (DHA%), and eicosapentaenoic acid (EPA%) as a percentage of total phospholipids, as well as serum interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), in 80 patients with major depressive disorder (MDD) and 24 healthy controls (HC). Individual PUFA and cytokine species were compared using ANOVA across four suicide risk-stratified groups: 1) highest-risk, recent (within 5 years) suicide attempters (n = 20); 2) high-risk, severe current suicidal ideators (having intent or plan) with no recent attempt history (n = 22); 3) low-risk, current non-ideators who were also lifetime non-attempters (n = 38); and 4) HC (n = 24). None of the participants were enrolled following an acute suicide attempt. Of biomarkers studied, only DHA% (p = 0.012) and IL-1β (p = 0.002) differed between groups. In post-hoc testing, DHA% was lower in attempters than ideators (p = 0.018) or MDD non-ideators (trend level, p = 0.073). IL-1β was lowest in attempters, differentiating them from ideators (p = 0.009) and HC (p = 0.004). Recent suicide attempt, one of the most powerful predictors of suicide risk, was also most closely tied to inflammatory indices in this study. Low DHA% as an indicator of suicide risk is consistent with previous reports; however, lower IL-1β was unexpected and may relate to acuity/chronicity of inflammation. There is a need for prospective studies of immune status with respect to suicidal behaviors. |
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| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/74101279-fda0-4d34-a97f-2f38f6f37f2a/download |
| id | ul_d090a7a937901ac9622a08a7bb487c4d |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/45998 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/45998 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Ganança, Licínia Galfalvy, Hanga C. Cisneros-Trujillo, Sebastian Basseda, Zahra Cooper, Thomas B. Ren, Xinguo Figueira, Maria Luísa Figueira, Maria Luísa https://www.ciencia-id.pt/4018-A916-81EC 4018-A916-81EC http://orcid.org/0000-0002-7921-5375 0000-0002-7921-5375 Oquendo, Maria A. Mann, J. John Sublette, M. Elizabeth |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
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| spelling | engElsevierpt_PTPro-inflammatory status has been implicated in depression and suicidal behaviors. Polyunsaturated fatty acids (PUFAs) and cytokines, two types of inflammatory biomarkers, have been associated with suicide, independent of depression severity. How these biomarkers relate to each other is less clear. We measured plasma phospholipid levels of arachidonic acid (AA%), docosahexaenoic acid (DHA%), and eicosapentaenoic acid (EPA%) as a percentage of total phospholipids, as well as serum interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor α (TNF-α), in 80 patients with major depressive disorder (MDD) and 24 healthy controls (HC). Individual PUFA and cytokine species were compared using ANOVA across four suicide risk-stratified groups: 1) highest-risk, recent (within 5 years) suicide attempters (n = 20); 2) high-risk, severe current suicidal ideators (having intent or plan) with no recent attempt history (n = 22); 3) low-risk, current non-ideators who were also lifetime non-attempters (n = 38); and 4) HC (n = 24). None of the participants were enrolled following an acute suicide attempt. Of biomarkers studied, only DHA% (p = 0.012) and IL-1β (p = 0.002) differed between groups. In post-hoc testing, DHA% was lower in attempters than ideators (p = 0.018) or MDD non-ideators (trend level, p = 0.073). IL-1β was lowest in attempters, differentiating them from ideators (p = 0.009) and HC (p = 0.004). Recent suicide attempt, one of the most powerful predictors of suicide risk, was also most closely tied to inflammatory indices in this study. Low DHA% as an indicator of suicide risk is consistent with previous reports; however, lower IL-1β was unexpected and may relate to acuity/chronicity of inflammation. There is a need for prospective studies of immune status with respect to suicidal behaviors.application/pdfpt_PTRelationships between inflammatory markers and suicide risk status in major depressionGanança, LicíniaGalfalvy, Hanga C.Cisneros-Trujillo, SebastianBasseda, ZahraCooper, Thomas B.Ren, XinguoPersonalFigueira, Maria LuísaDSpacehttp://dspace.org/items/dd3c81c3-e160-4582-ba61-0c7d9548cf43DSpacehttp://dspace.org/items/dd3c81c3-e160-4582-ba61-0c7d9548cf43FigueiraMaria LuisaCiência IDhttps://www.ciencia-id.pt4018-A916-81ECORCIDhttp://orcid.org0000-0002-7921-5375Oquendo, Maria A.Mann, J. JohnSublette, M. ElizabethHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0022-3956DOIIsPartOf10.1016/j.jpsychires.2020.12.0292021-01-29T17:20:10Z20212021-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/45998http://purl.org/coar/access_right/c_16ecrestricted accessInflammationCytokinesOmega-3 polyunsaturated fatty acids (PUFA)SuicideDepression1249762 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/74101279-fda0-4d34-a97f-2f38f6f37f2a/downloadJournal of Psychiatric Research134192199 |
| spellingShingle | Relationships between inflammatory markers and suicide risk status in major depression Relationships between inflammatory markers and suicide risk status in major depression Ganança, Licínia Inflammation Cytokines Omega-3 polyunsaturated fatty acids (PUFA) Suicide Depression Ganança, Licínia Inflammation Cytokines Omega-3 polyunsaturated fatty acids (PUFA) Suicide Depression |
| status | SINGLETON |
| subject.fl_str_mv | Inflammation Cytokines Omega-3 polyunsaturated fatty acids (PUFA) Suicide Depression |
| title | Relationships between inflammatory markers and suicide risk status in major depression |
| title_full | Relationships between inflammatory markers and suicide risk status in major depression |
| title_fullStr | Relationships between inflammatory markers and suicide risk status in major depression Relationships between inflammatory markers and suicide risk status in major depression |
| title_full_unstemmed | Relationships between inflammatory markers and suicide risk status in major depression Relationships between inflammatory markers and suicide risk status in major depression |
| title_short | Relationships between inflammatory markers and suicide risk status in major depression |
| title_sort | Relationships between inflammatory markers and suicide risk status in major depression |
| topic | Inflammation Cytokines Omega-3 polyunsaturated fatty acids (PUFA) Suicide Depression |
| topic_facet | Inflammation Cytokines Omega-3 polyunsaturated fatty acids (PUFA) Suicide Depression |
| url | http://hdl.handle.net/10451/45998 |
| visible | 1 |