Publicação
Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system
| Resumo: | Background: Myriads of signaling pathways in a single cell function to achieve the highest spatio-temporal integration. Data are accumulating on the role of electromechanical soliton-like waves in signal transduction processes. Theoretical studies strongly suggest feasibility of both classical and quantum computing involving microtubules. Aim: A theoretical study of the role of the complex composed of the plasma membrane and the microtubule-based cytoskeleton as a system that transmits, stores and processes information. Methods: Theoretical analysis presented here refers to (i) the Penrose–Hameroff theory of consciousness (Orchestrated Objective Reduction; Orch OR), (ii) the description of the centrosome as a reference system for construction of the 3D map of the cell proposed by Regolini, (iii) the Heimburg–Jackson model of the nerve pulse propagation along axons’ lipid bilayer as soliton-like electro-mechanical waves. Results and conclusion: The ideas presented in this paper provide a qualitative model for the decision-making processes in a living cell undergoing a differentiation process. Outlook: This paper paves the way for the real-time live-cell observation of information processing by microtubule-based cytoskeleton and cell fate decision making. |
|---|---|
| Autores principais: | Barvitenko, Nadezhda |
| Outros Autores: | Lawen, Alfons; Aslam, Muhammad; Pantaleo, Antonella; Saldanha, Carlota; Skverchinskaya, Elisaveta; Regolini, Marco; Tuszynski, Jack A. |
| Assunto: | Tubulin Microtubule Centrosome Signaling Memory Signal transduction |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866811094538911744 |
|---|---|
| author | Barvitenko, Nadezhda |
| author2 | Lawen, Alfons Aslam, Muhammad Pantaleo, Antonella Saldanha, Carlota Skverchinskaya, Elisaveta Regolini, Marco Tuszynski, Jack A. |
| author2_role | author author author author author author author |
| author_facet | Barvitenko, Nadezhda Lawen, Alfons Aslam, Muhammad Pantaleo, Antonella Saldanha, Carlota Skverchinskaya, Elisaveta Regolini, Marco Tuszynski, Jack A. |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Barvitenko, Nadezhda\"},{\"Person.name\":\"Lawen, Alfons\"},{\"Person.name\":\"Aslam, Muhammad\"},{\"Person.name\":\"Pantaleo, Antonella\"},{\"Person.name\":\"Saldanha, Carlota\",\"Person.identifier.orcid\":\"0000-0002-5058-2112\"},{\"Person.name\":\"Skverchinskaya, Elisaveta\"},{\"Person.name\":\"Regolini, Marco\"},{\"Person.name\":\"Tuszynski, Jack A.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Barvitenko, Nadezhda Lawen, Alfons Aslam, Muhammad Pantaleo, Antonella Saldanha, Carlota Skverchinskaya, Elisaveta Regolini, Marco Tuszynski, Jack A. |
| datacite.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-10-21T11:01:49Z |
| datacite.date.embargoed.fl_str_mv | 2020-10-21T11:01:49Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Tubulin Microtubule Centrosome Signaling Memory Signal transduction |
| datacite.titles.title.fl_str_mv | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Barvitenko, Nadezhda Lawen, Alfons Aslam, Muhammad Pantaleo, Antonella Saldanha, Carlota Skverchinskaya, Elisaveta Regolini, Marco Tuszynski, Jack A. |
| dc.date.Accepted.fl_str_mv | 2018-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-10-21T11:01:49Z |
| dc.date.embargoed.fl_str_mv | 2020-10-21T11:01:49Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/44627 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Tubulin Microtubule Centrosome Signaling Memory Signal transduction |
| dc.title.fl_str_mv | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: Myriads of signaling pathways in a single cell function to achieve the highest spatio-temporal integration. Data are accumulating on the role of electromechanical soliton-like waves in signal transduction processes. Theoretical studies strongly suggest feasibility of both classical and quantum computing involving microtubules. Aim: A theoretical study of the role of the complex composed of the plasma membrane and the microtubule-based cytoskeleton as a system that transmits, stores and processes information. Methods: Theoretical analysis presented here refers to (i) the Penrose–Hameroff theory of consciousness (Orchestrated Objective Reduction; Orch OR), (ii) the description of the centrosome as a reference system for construction of the 3D map of the cell proposed by Regolini, (iii) the Heimburg–Jackson model of the nerve pulse propagation along axons’ lipid bilayer as soliton-like electro-mechanical waves. Results and conclusion: The ideas presented in this paper provide a qualitative model for the decision-making processes in a living cell undergoing a differentiation process. Outlook: This paper paves the way for the real-time live-cell observation of information processing by microtubule-based cytoskeleton and cell fate decision making. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/5c6429de-84ac-4594-9329-e9635c2ead6c/download |
| id | ul_d254ccb4595ea69e150c4e9c4be83efd |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/44627 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/44627 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Barvitenko, Nadezhda Lawen, Alfons Aslam, Muhammad Pantaleo, Antonella Saldanha, Carlota Saldanha, Carlota http://orcid.org/0000-0002-5058-2112 0000-0002-5058-2112 Skverchinskaya, Elisaveta Regolini, Marco Tuszynski, Jack A. |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engElsevierpt_PTBackground: Myriads of signaling pathways in a single cell function to achieve the highest spatio-temporal integration. Data are accumulating on the role of electromechanical soliton-like waves in signal transduction processes. Theoretical studies strongly suggest feasibility of both classical and quantum computing involving microtubules. Aim: A theoretical study of the role of the complex composed of the plasma membrane and the microtubule-based cytoskeleton as a system that transmits, stores and processes information. Methods: Theoretical analysis presented here refers to (i) the Penrose–Hameroff theory of consciousness (Orchestrated Objective Reduction; Orch OR), (ii) the description of the centrosome as a reference system for construction of the 3D map of the cell proposed by Regolini, (iii) the Heimburg–Jackson model of the nerve pulse propagation along axons’ lipid bilayer as soliton-like electro-mechanical waves. Results and conclusion: The ideas presented in this paper provide a qualitative model for the decision-making processes in a living cell undergoing a differentiation process. Outlook: This paper paves the way for the real-time live-cell observation of information processing by microtubule-based cytoskeleton and cell fate decision making.application/pdfpt_PTIntegration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference systemBarvitenko, NadezhdaLawen, AlfonsAslam, MuhammadPantaleo, AntonellaPersonalSaldanha, CarlotaDSpacehttp://dspace.org/items/ad6de30c-87ca-4613-bb87-488dd5d285d0DSpacehttp://dspace.org/items/ad6de30c-87ca-4613-bb87-488dd5d285d0SaldanhaCarlotaORCIDhttp://orcid.org0000-0002-5058-2112Skverchinskaya, ElisavetaRegolini, MarcoTuszynski, Jack A.HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0303-2647DOIIsPartOf10.1016/j.biosystems.2018.08.0072020-10-21T11:01:49Z20182018-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/44627http://purl.org/coar/access_right/c_16ecrestricted accessTubulinMicrotubuleCentrosomeSignalingMemorySignal transduction2107514 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/5c6429de-84ac-4594-9329-e9635c2ead6c/downloadBiosystems173191206 |
| spellingShingle | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system Barvitenko, Nadezhda Tubulin Microtubule Centrosome Signaling Memory Signal transduction |
| status | SINGLETON |
| subject.fl_str_mv | Tubulin Microtubule Centrosome Signaling Memory Signal transduction |
| title | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system |
| title_full | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system |
| title_fullStr | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system |
| title_full_unstemmed | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system |
| title_short | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system |
| title_sort | Integration of intracellular signaling : biological analogues of wires, processors and memories organized by a centrosome 3D reference system |
| topic | Tubulin Microtubule Centrosome Signaling Memory Signal transduction |
| topic_facet | Tubulin Microtubule Centrosome Signaling Memory Signal transduction |
| url | http://hdl.handle.net/10451/44627 |
| visible | 1 |