Publicação
24-hour rhythmicity of seizures in refractory focal epilepsy
| Resumo: | The occurrence of seizures in specific types of epilepsies can follow a 24-hour nonuniform or nonrandom pattern. We described the 24-hour pattern of clinical seizures in patients with focal refractory epilepsy who underwent video-electroencephalography monitoring. Only patients who were candidates for epilepsy surgery with an unequivocal seizure focus were included in the study. A total of 544 seizures from 123 consecutive patients were analyzed. Specific time of seizures were distributed along 3- or 4-hour time blocks or bins throughout the 24-hour period. The mean age of the subjects was 37.7 years, with standard deviation of 11.5 years, median of 37. The majority were females (70/56%). The majority of patients had a seizure focus located in the mesial temporal lobe (102/83%) and in the neocortical temporal lobe (13/11%). The remaining patients had a seizure focus located in the extratemporal lobe (8/6%). The most common etiology was mesial temporal sclerosis (86/69.9%). Nonuniform seizure distribution was observed in seizures arising from the temporal lobe (mesial temporal lobe and neocortical temporal lobe), with two peaks found in both 3- and 4-hour bins: 10:00-13:00/16:00-19:00 and 08:00-12:00/16:00-20:00 respectively (p=0.004). No specific 24-hour pattern was identified in seizures from extratemporal location. The 24-hour rhythmicity of seizure distribution is recognized in certain types of epilepsy, but studies on the topic are scarce. Their replication and validation is therefore needed. Our study confirms the bimodal pattern of temporal lobe epilepsy independently of the nature of the lesion. However, peak times differ between different studies, suggesting that the ambient, rhythmic exogenous factors or environmental/social zeitgebers, may modulate the 24-hour rhythmicity of seizures. Characterization of these 24-hour patterns of seizure occurrence can influence diagnosis and treatment in selected types of epilepsy, such as the case of temporal lobe epilepsy, the most common drug-resistant epilepsy. |
|---|---|
| Autores principais: | Nzwalo, Hipólito |
| Outros Autores: | Menezes Cordeiro, Inês; Santos, Ana Catarina; Peralta, Ana; Paiva, Teresa; Bentes, Carla |
| Assunto: | Epilepsy Seizures 24-hour rhythmicity |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866811122335612928 |
|---|---|
| author | Nzwalo, Hipólito |
| author2 | Menezes Cordeiro, Inês Santos, Ana Catarina Peralta, Ana Paiva, Teresa Bentes, Carla |
| author2_role | author author author author author |
| author_facet | Nzwalo, Hipólito Menezes Cordeiro, Inês Santos, Ana Catarina Peralta, Ana Paiva, Teresa Bentes, Carla |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Nzwalo, Hipólito\"},{\"Person.name\":\"Menezes Cordeiro, Inês\"},{\"Person.name\":\"Santos, Ana Catarina\"},{\"Person.name\":\"Peralta, Ana\",\"Person.identifier.orcid\":\"0000-0001-9449-431X\"},{\"Person.name\":\"Paiva, Teresa\",\"Person.identifier.orcid\":\"0000-0002-7937-7841\"},{\"Person.name\":\"Bentes, Carla\",\"Person.identifier.orcid\":\"0000-0003-2399-7678\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Nzwalo, Hipólito Menezes Cordeiro, Inês Santos, Ana Catarina Peralta, Ana Paiva, Teresa Bentes, Carla |
| datacite.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-11-09T14:48:18Z |
| datacite.date.embargoed.fl_str_mv | 2023-11-09T14:48:18Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Epilepsy Seizures 24-hour rhythmicity |
| datacite.titles.title.fl_str_mv | 24-hour rhythmicity of seizures in refractory focal epilepsy |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Nzwalo, Hipólito Menezes Cordeiro, Inês Santos, Ana Catarina Peralta, Ana Paiva, Teresa Bentes, Carla |
| dc.date.Accepted.fl_str_mv | 2016-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-11-09T14:48:18Z |
| dc.date.embargoed.fl_str_mv | 2023-11-09T14:48:18Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/60254 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Epilepsy Seizures 24-hour rhythmicity |
| dc.title.fl_str_mv | 24-hour rhythmicity of seizures in refractory focal epilepsy |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The occurrence of seizures in specific types of epilepsies can follow a 24-hour nonuniform or nonrandom pattern. We described the 24-hour pattern of clinical seizures in patients with focal refractory epilepsy who underwent video-electroencephalography monitoring. Only patients who were candidates for epilepsy surgery with an unequivocal seizure focus were included in the study. A total of 544 seizures from 123 consecutive patients were analyzed. Specific time of seizures were distributed along 3- or 4-hour time blocks or bins throughout the 24-hour period. The mean age of the subjects was 37.7 years, with standard deviation of 11.5 years, median of 37. The majority were females (70/56%). The majority of patients had a seizure focus located in the mesial temporal lobe (102/83%) and in the neocortical temporal lobe (13/11%). The remaining patients had a seizure focus located in the extratemporal lobe (8/6%). The most common etiology was mesial temporal sclerosis (86/69.9%). Nonuniform seizure distribution was observed in seizures arising from the temporal lobe (mesial temporal lobe and neocortical temporal lobe), with two peaks found in both 3- and 4-hour bins: 10:00-13:00/16:00-19:00 and 08:00-12:00/16:00-20:00 respectively (p=0.004). No specific 24-hour pattern was identified in seizures from extratemporal location. The 24-hour rhythmicity of seizure distribution is recognized in certain types of epilepsy, but studies on the topic are scarce. Their replication and validation is therefore needed. Our study confirms the bimodal pattern of temporal lobe epilepsy independently of the nature of the lesion. However, peak times differ between different studies, suggesting that the ambient, rhythmic exogenous factors or environmental/social zeitgebers, may modulate the 24-hour rhythmicity of seizures. Characterization of these 24-hour patterns of seizure occurrence can influence diagnosis and treatment in selected types of epilepsy, such as the case of temporal lobe epilepsy, the most common drug-resistant epilepsy. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/ab3f39bc-85f4-49d6-a073-0dc15636c720/download |
| id | ul_d3ed62df5e2d26bdb5965a09f8fbc948 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/60254 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/60254 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Nzwalo, Hipólito Menezes Cordeiro, Inês Santos, Ana Catarina Peralta, Ana Peralta, Ana https://www.ciencia-id.pt/1D1D-D037-54D8 1D1D-D037-54D8 http://orcid.org/0000-0001-9449-431X 0000-0001-9449-431X Paiva, Teresa Paiva, Teresa https://www.ciencia-id.pt/7B10-224A-DB1D 7B10-224A-DB1D http://orcid.org/0000-0002-7937-7841 0000-0002-7937-7841 Bentes, Carla Bentes, Carla https://www.ciencia-id.pt/7D1C-D5DD-C579 7D1C-D5DD-C579 http://orcid.org/0000-0003-2399-7678 0000-0003-2399-7678 |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engElsevierpt_PTThe occurrence of seizures in specific types of epilepsies can follow a 24-hour nonuniform or nonrandom pattern. We described the 24-hour pattern of clinical seizures in patients with focal refractory epilepsy who underwent video-electroencephalography monitoring. Only patients who were candidates for epilepsy surgery with an unequivocal seizure focus were included in the study. A total of 544 seizures from 123 consecutive patients were analyzed. Specific time of seizures were distributed along 3- or 4-hour time blocks or bins throughout the 24-hour period. The mean age of the subjects was 37.7 years, with standard deviation of 11.5 years, median of 37. The majority were females (70/56%). The majority of patients had a seizure focus located in the mesial temporal lobe (102/83%) and in the neocortical temporal lobe (13/11%). The remaining patients had a seizure focus located in the extratemporal lobe (8/6%). The most common etiology was mesial temporal sclerosis (86/69.9%). Nonuniform seizure distribution was observed in seizures arising from the temporal lobe (mesial temporal lobe and neocortical temporal lobe), with two peaks found in both 3- and 4-hour bins: 10:00-13:00/16:00-19:00 and 08:00-12:00/16:00-20:00 respectively (p=0.004). No specific 24-hour pattern was identified in seizures from extratemporal location. The 24-hour rhythmicity of seizure distribution is recognized in certain types of epilepsy, but studies on the topic are scarce. Their replication and validation is therefore needed. Our study confirms the bimodal pattern of temporal lobe epilepsy independently of the nature of the lesion. However, peak times differ between different studies, suggesting that the ambient, rhythmic exogenous factors or environmental/social zeitgebers, may modulate the 24-hour rhythmicity of seizures. Characterization of these 24-hour patterns of seizure occurrence can influence diagnosis and treatment in selected types of epilepsy, such as the case of temporal lobe epilepsy, the most common drug-resistant epilepsy.application/pdfpt_PT24-hour rhythmicity of seizures in refractory focal epilepsyNzwalo, HipólitoMenezes Cordeiro, InêsSantos, Ana CatarinaPersonalPeralta, AnaDSpacehttp://dspace.org/items/f365f74e-2a70-4578-9ac1-2f945334c6b0DSpacehttp://dspace.org/items/f365f74e-2a70-4578-9ac1-2f945334c6b0PeraltaAna RitaCiência IDhttps://www.ciencia-id.pt1D1D-D037-54D8ORCIDhttp://orcid.org0000-0001-9449-431XPersonalPaiva, TeresaDSpacehttp://dspace.org/items/c720c5dd-a926-4737-938d-a90e782dd837DSpacehttp://dspace.org/items/c720c5dd-a926-4737-938d-a90e782dd837PaivaMaria Teresa Aguiar dos SantosCiência IDhttps://www.ciencia-id.pt7B10-224A-DB1DORCIDhttp://orcid.org0000-0002-7937-7841Scopus Author IDhttps://www.scopus.com7005950248PersonalBentes, CarlaDSpacehttp://dspace.org/items/0bc2f877-0ad3-408c-82ee-b5378a014734DSpacehttp://dspace.org/items/0bc2f877-0ad3-408c-82ee-b5378a014734BentesCarlaCiência IDhttps://www.ciencia-id.pt7D1C-D5DD-C579ORCIDhttp://orcid.org0000-0003-2399-7678Scopus Author IDhttps://www.scopus.com6603395191HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf1525-5050DOIIsPartOf10.1016/j.yebeh.2015.12.0052023-11-09T14:48:18Z20162016-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/60254http://purl.org/coar/access_right/c_16ecrestricted accessEpilepsySeizures24-hour rhythmicity515579 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/ab3f39bc-85f4-49d6-a073-0dc15636c720/downloadEpilepsy & Behavior557578 |
| spellingShingle | 24-hour rhythmicity of seizures in refractory focal epilepsy Nzwalo, Hipólito Epilepsy Seizures 24-hour rhythmicity |
| status | SINGLETON |
| subject.fl_str_mv | Epilepsy Seizures 24-hour rhythmicity |
| title | 24-hour rhythmicity of seizures in refractory focal epilepsy |
| title_full | 24-hour rhythmicity of seizures in refractory focal epilepsy |
| title_fullStr | 24-hour rhythmicity of seizures in refractory focal epilepsy |
| title_full_unstemmed | 24-hour rhythmicity of seizures in refractory focal epilepsy |
| title_short | 24-hour rhythmicity of seizures in refractory focal epilepsy |
| title_sort | 24-hour rhythmicity of seizures in refractory focal epilepsy |
| topic | Epilepsy Seizures 24-hour rhythmicity |
| topic_facet | Epilepsy Seizures 24-hour rhythmicity |
| url | http://hdl.handle.net/10451/60254 |
| visible | 1 |