Publicação
Micro RNAs in Tfh regulation : small molecules with a big impact
| Resumo: | ABSTRACT - The germinal center (GC) reactions are critical for the production of high-affinity antibodies that comprise the protective humoral response elicited by infection or vaccination. GCs are initiated through the interaction of B cells with T follicular helper (Tfh) cells. While the transcriptional regulation of Tfh differentiation has been studied in great detail, the impact of micro RNAs (miRNAs) on Tfh development and stability has been harder to address. It was previously shown that a complete deletion of miRNAs biogenesis prevents Tfh differentiation. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2021. 51: 408-413], Zeiträg et al. use an inducible gene deletion approach to reveal that miRNAs are also required for the maintenance of Tfh cells induced following viral infection in mice. These results provide new clues to the regulation of GC responses through Tfh and T follicular regulatory cells. |
|---|---|
| Autores principais: | Basto, Afonso P. |
| Outros Autores: | Graca, Luis |
| Assunto: | Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1865920842527932416 |
|---|---|
| author | Basto, Afonso P. |
| author2 | Graca, Luis |
| author2_role | author |
| author_facet | Basto, Afonso P. Basto, Afonso P. Graca, Luis Graca, Luis |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Basto, Afonso P.\",\"Person.identifier.orcid\":\"0000-0002-4651-1338\"},{\"Person.name\":\"Graca, Luis\",\"Person.identifier.orcid\":\"0000-0001-6935-8500\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Basto, Afonso P. Graca, Luis |
| datacite.date.Accepted.fl_str_mv | 2021-02-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-01-19T17:58:17Z |
| datacite.date.embargoed.fl_str_mv | 2022-01-19T17:58:17Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center |
| datacite.titles.title.fl_str_mv | Micro RNAs in Tfh regulation : small molecules with a big impact |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Basto, Afonso P. Graca, Luis |
| dc.date.Accepted.fl_str_mv | 2021-02-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-01-19T17:58:17Z |
| dc.date.embargoed.fl_str_mv | 2022-01-19T17:58:17Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.5/23172 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center |
| dc.title.fl_str_mv | Micro RNAs in Tfh regulation : small molecules with a big impact |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | ABSTRACT - The germinal center (GC) reactions are critical for the production of high-affinity antibodies that comprise the protective humoral response elicited by infection or vaccination. GCs are initiated through the interaction of B cells with T follicular helper (Tfh) cells. While the transcriptional regulation of Tfh differentiation has been studied in great detail, the impact of micro RNAs (miRNAs) on Tfh development and stability has been harder to address. It was previously shown that a complete deletion of miRNAs biogenesis prevents Tfh differentiation. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2021. 51: 408-413], Zeiträg et al. use an inducible gene deletion approach to reveal that miRNAs are also required for the maintenance of Tfh cells induced following viral infection in mice. These results provide new clues to the regulation of GC responses through Tfh and T follicular regulatory cells. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/43b0b8b8-c550-4e7c-8230-45ab30e9f8d2/download |
| id | ul_dc3aee494b7e6aefe8d2ca6db36f39c4 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.5/23172 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10400.5/23172 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Basto, Afonso P. Basto, Afonso P. https://www.ciencia-id.pt/A81A-BBD8-EB94 A81A-BBD8-EB94 http://orcid.org/0000-0002-4651-1338 0000-0002-4651-1338 Graca, Luis Graca, Luis https://www.ciencia-id.pt/6C19-B162-F561 6C19-B162-F561 http://orcid.org/0000-0001-6935-8500 0000-0001-6935-8500 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Wiley |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engWileypt_PTABSTRACT - The germinal center (GC) reactions are critical for the production of high-affinity antibodies that comprise the protective humoral response elicited by infection or vaccination. GCs are initiated through the interaction of B cells with T follicular helper (Tfh) cells. While the transcriptional regulation of Tfh differentiation has been studied in great detail, the impact of micro RNAs (miRNAs) on Tfh development and stability has been harder to address. It was previously shown that a complete deletion of miRNAs biogenesis prevents Tfh differentiation. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2021. 51: 408-413], Zeiträg et al. use an inducible gene deletion approach to reveal that miRNAs are also required for the maintenance of Tfh cells induced following viral infection in mice. These results provide new clues to the regulation of GC responses through Tfh and T follicular regulatory cells.application/pdfpt_PTMicro RNAs in Tfh regulation : small molecules with a big impactPersonalBasto, Afonso P.DSpacehttp://dspace.org/items/16983b3e-a7c8-4343-81e8-cdb5af2216f9DSpacehttp://dspace.org/items/16983b3e-a7c8-4343-81e8-cdb5af2216f9Silva Pinto BastoAfonsoCiência IDhttps://www.ciencia-id.ptA81A-BBD8-EB94ORCIDhttp://orcid.org0000-0002-4651-1338PersonalGraca, LuisDSpacehttp://dspace.org/items/7f8b0ef9-8ff5-4d0e-a1bc-a19780bc7b7eDSpacehttp://dspace.org/items/7f8b0ef9-8ff5-4d0e-a1bc-a19780bc7b7eSilva GracaLuis RicardoCiência IDhttps://www.ciencia-id.pt6C19-B162-F561ORCIDhttp://orcid.org0000-0001-6935-8500Scopus Author IDhttps://www.scopus.com36138488700HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0014-2980DOIIsPartOf10.1002/eji.2020490862022-01-19T17:58:17Z2021-022021-02-01T00:00:00ZHandlehttp://hdl.handle.net/10400.5/23172http://purl.org/coar/access_right/c_abf2open accessMicro RNAsT follicular helper cellsT follicular regulatory cellsGerminal center1477077 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2021-02http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/43b0b8b8-c550-4e7c-8230-45ab30e9f8d2/downloadEuropean Journal of ImmunologyV.51(2)291295HOBOKEN, NJ |
| spellingShingle | Micro RNAs in Tfh regulation : small molecules with a big impact Micro RNAs in Tfh regulation : small molecules with a big impact Basto, Afonso P. Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center Basto, Afonso P. Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center |
| status | SINGLETON |
| subject.fl_str_mv | Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center |
| title | Micro RNAs in Tfh regulation : small molecules with a big impact |
| title_full | Micro RNAs in Tfh regulation : small molecules with a big impact |
| title_fullStr | Micro RNAs in Tfh regulation : small molecules with a big impact Micro RNAs in Tfh regulation : small molecules with a big impact |
| title_full_unstemmed | Micro RNAs in Tfh regulation : small molecules with a big impact Micro RNAs in Tfh regulation : small molecules with a big impact |
| title_short | Micro RNAs in Tfh regulation : small molecules with a big impact |
| title_sort | Micro RNAs in Tfh regulation : small molecules with a big impact |
| topic | Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center |
| topic_facet | Micro RNAs T follicular helper cells T follicular regulatory cells Germinal center |
| url | http://hdl.handle.net/10400.5/23172 |
| visible | 1 |