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Preparation of scored orodispersible tablets with a new type of punches using design of experiments

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Resumo:Oral drug delivery continues to be the most preferred route for administration of various therapeutic agents. A lot of research has been done in the sense of discovery and develop new drug delivery systems. This work focus on the development of orodispersible tablets as an alternative to other solid dosage forms, especially for people who have difficulty in swallowing (dysphagia) or who need a rapid onset of therapeutic action in order to increase bioavailability. Quick absorption, rapid onset of action and increased bioavailability (by decreasing the first-pass effect) are the main advantages associated to this dosage form. The objective of the present study was to optimize, formulate and evaluate orally dispersible tablets (ODTs) of Furosemide presenting score lines using a new type of punches (Easy Breakable Tablet -EBT). Tablets were prepared by Direct Compression at relatively low pressure forces. Afterwards, the tablets obtained were evaluated in terms of weight variation, thickness, diameter, friability, hardness, disintegration time, wetting time, water absorption ratio, effervescence time and uniformity content. Through Design of Experiments (DoE), was evaluated the relationship between factors or independent variables (force, weight, speed and punch type) and the response variables or dependent variables (e.g. tablets thickness). Taking into consideration the desirability approach, the desired levels for each factor were determined to obtain ODTs with the most convenient characteristics. The tablets obtained revealed good mechanical properties but prolonged disintegration times. Considering that they are orodispersible tablets which are intended to be dispersed in the mouth in a matter of seconds, these results arise the need to realize further studies in order to improve the tablets disintegration efficacy.
Autores principais:Oliveira, Tânia Patrícia Abreu
Assunto:Design of experiments Direct compression Furosemide Oral dispersible tablets Punch type Score line Mestrado Integrado - 2016
Ano:2016
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso restrito
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa

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