Publicação
Biological effects of thoracic irradiation with low to moderate daily doses on rat lung
| Resumo: | Radiotherapy (RT) plays a major role in breast cancer treatment, reducing local recurrence and deaths resulting from this malignant disease. However, it can lead to heart and lung toxicity, due to the incidental irradiation of these tumor-adjacent normal tissues with subtherapeutic doses of ionizing radiation (IR), in a variable range of doses. Although evolution of RT techniques has allowed a reduction of the mean dose received by these tissues, higher non-target volumes are irradiated with low-dose ionizing radiation (LDIR). Despite this apparent benefit, the health effects of LDIR are still controversial and needs further investigation. In this context, the European MEDIRAD project aims to clarify whether LDIR induces heart and lung toxicity and if so, which is the minimum dose responsible for that. In the scope of the MEDIRAD project, the present thesis aims to characterize the biological effects of low to moderate doses of IR on rat lungs. |
|---|---|
| Autores principais: | Rocha, Filipe Nunes |
| Assunto: | Irradiação torácica Ratazanas Wistar Pulmão Doses baixas e moderadas de radiação ionizante Fibrose pulmonar e pneumonite Teses de mestrado - 2019 |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| Resumo: | Radiotherapy (RT) plays a major role in breast cancer treatment, reducing local recurrence and deaths resulting from this malignant disease. However, it can lead to heart and lung toxicity, due to the incidental irradiation of these tumor-adjacent normal tissues with subtherapeutic doses of ionizing radiation (IR), in a variable range of doses. Although evolution of RT techniques has allowed a reduction of the mean dose received by these tissues, higher non-target volumes are irradiated with low-dose ionizing radiation (LDIR). Despite this apparent benefit, the health effects of LDIR are still controversial and needs further investigation. In this context, the European MEDIRAD project aims to clarify whether LDIR induces heart and lung toxicity and if so, which is the minimum dose responsible for that. In the scope of the MEDIRAD project, the present thesis aims to characterize the biological effects of low to moderate doses of IR on rat lungs. |
|---|