Publicação
Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort
| Resumo: | Evidence for the role of sex in the clinical manifestations of systemic sclerosis (SSc) patients is emerging. Some multicenter cohorts have shown that male SSc patients have more severe disease and worse survival. To assess the differences in clinical manifestations and survival in Portuguese SSc patients according to gender. Data from male and female adult SSc patients included in the Rheumatic Diseases Portuguese Register (Reuma.pt) were analysed and compared. Survival was calculated for patients included in Reuma.pt. within the first two years of diagnosis (inception cohort). In total, 1054 adult patients with SSc were included, 12.5% males. No differences in demographic features and comorbidities were found between the sexes, except for a higher rate of cigarette smokers among men. Diffuse cutaneous SSc and anti-topoisomerase antibodies were more prevalent in males than females. Additionally, male patients presented significantly more myositis, interstitial lung disease and gastric involvement. There were no differences in the patterns of drug use between the sexes. During follow-up, more deaths were reported in men than women (12.1% vs 7.3%, p = 0.04). The overall 1-, 3-, and 5-year survivals from diagnosis of the inception cohort (N = 469) for men vs women were 96.4% vs 98.2%, 93% vs 95.9%, and 75.8% vs 93.2%, respectively, with statistically significant differences (p < 0.01). This study confirms the existence of gender differences in clinical and immunological SSc features. Although SSc is less common in men than women, men have a more severe expression of skin and internal organ involvement and worse survival. Key Points • There are differences in SSc disease manifestations between sexes. • Males more commonly have diffuse cutaneous SSc, anti-topoisomerase antibodies, pulmonary and musculoskeletal involvement. • In the inception cohort, men had worse survival rates than women. |
|---|---|
| Autores principais: | Freitas, Raquel |
| Outros Autores: | Martins, Patrícia; Dourado, Eduardo; Santiago, Tânia; Guimarães, Francisca; Fernandes, Bruno Miguel; Garcia, Salomé; Samões, Beatriz; Pinto, Ana Sofia; Gonçalves, Nuno; Lourenco, Maria Helena; Costa, Emanuel; Rocha, Margarida; Couto, Maura; Duarte, Ana Catarina; Araújo, Filipe; Cordeiro, Inês; Godinho, Fátima; Resende, Catarina; Salvador, Maria João; Cordeiro, Ana; Santos, Maria José |
| Assunto: | Cohort Gender differences Survival Systemic sclerosis |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1865920848139911168 |
|---|---|
| author | Freitas, Raquel |
| author2 | Martins, Patrícia Dourado, Eduardo Santiago, Tânia Guimarães, Francisca Fernandes, Bruno Miguel Garcia, Salomé Samões, Beatriz Pinto, Ana Sofia Gonçalves, Nuno Lourenco, Maria Helena Costa, Emanuel Rocha, Margarida Couto, Maura Duarte, Ana Catarina Araújo, Filipe Cordeiro, Inês Godinho, Fátima Resende, Catarina Salvador, Maria João Cordeiro, Ana Santos, Maria José |
| author2_role | author author author author author author author author author author author author author author author author author author author author author |
| author_facet | Freitas, Raquel Freitas, Raquel Martins, Patrícia Dourado, Eduardo Santiago, Tânia Guimarães, Francisca Fernandes, Bruno Miguel Garcia, Salomé Samões, Beatriz Pinto, Ana Sofia Gonçalves, Nuno Lourenco, Maria Helena Costa, Emanuel Rocha, Margarida Couto, Maura Duarte, Ana Catarina Araújo, Filipe Cordeiro, Inês Godinho, Fátima Resende, Catarina Salvador, Maria João Cordeiro, Ana Santos, Maria José Martins, Patrícia Dourado, Eduardo Santiago, Tânia Guimarães, Francisca Fernandes, Bruno Miguel Garcia, Salomé Samões, Beatriz Pinto, Ana Sofia Gonçalves, Nuno Lourenco, Maria Helena Costa, Emanuel Rocha, Margarida Couto, Maura Duarte, Ana Catarina Araújo, Filipe Cordeiro, Inês Godinho, Fátima Resende, Catarina Salvador, Maria João Cordeiro, Ana Santos, Maria José |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Freitas, Raquel\"},{\"Person.name\":\"Martins, Patrícia\",\"Person.identifier.orcid\":\"0000-0003-3578-7213\"},{\"Person.name\":\"Dourado, Eduardo\",\"Person.identifier.orcid\":\"0000-0003-2186-2833\"},{\"Person.name\":\"Santiago, Tânia\"},{\"Person.name\":\"Guimarães, Francisca\"},{\"Person.name\":\"Fernandes, Bruno Miguel\"},{\"Person.name\":\"Garcia, Salomé\"},{\"Person.name\":\"Samões, Beatriz\"},{\"Person.name\":\"Pinto, Ana Sofia\"},{\"Person.name\":\"Gonçalves, Nuno\"},{\"Person.name\":\"Lourenco, Maria Helena\"},{\"Person.name\":\"Costa, Emanuel\"},{\"Person.name\":\"Rocha, Margarida\"},{\"Person.name\":\"Couto, Maura\"},{\"Person.name\":\"Duarte, Ana Catarina\"},{\"Person.name\":\"Araújo, Filipe\"},{\"Person.name\":\"Cordeiro, Inês\",\"Person.identifier.orcid\":\"0000-0001-9308-6728\"},{\"Person.name\":\"Godinho, Fátima\"},{\"Person.name\":\"Resende, Catarina\"},{\"Person.name\":\"Salvador, Maria João\"},{\"Person.name\":\"Cordeiro, Ana\"},{\"Person.name\":\"Santos, Maria José\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Freitas, Raquel Martins, Patrícia Dourado, Eduardo Santiago, Tânia Guimarães, Francisca Fernandes, Bruno Miguel Garcia, Salomé Samões, Beatriz Pinto, Ana Sofia Gonçalves, Nuno Lourenco, Maria Helena Costa, Emanuel Rocha, Margarida Couto, Maura Duarte, Ana Catarina Araújo, Filipe Cordeiro, Inês Godinho, Fátima Resende, Catarina Salvador, Maria João Cordeiro, Ana Santos, Maria José |
| datacite.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-04-05T10:45:43Z |
| datacite.date.embargoed.fl_str_mv | 2022-04-05T10:45:43Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Cohort Gender differences Survival Systemic sclerosis |
| datacite.titles.title.fl_str_mv | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Freitas, Raquel Martins, Patrícia Dourado, Eduardo Santiago, Tânia Guimarães, Francisca Fernandes, Bruno Miguel Garcia, Salomé Samões, Beatriz Pinto, Ana Sofia Gonçalves, Nuno Lourenco, Maria Helena Costa, Emanuel Rocha, Margarida Couto, Maura Duarte, Ana Catarina Araújo, Filipe Cordeiro, Inês Godinho, Fátima Resende, Catarina Salvador, Maria João Cordeiro, Ana Santos, Maria José |
| dc.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-04-05T10:45:43Z |
| dc.date.embargoed.fl_str_mv | 2022-04-05T10:45:43Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/52172 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Springer Nature |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Cohort Gender differences Survival Systemic sclerosis |
| dc.title.fl_str_mv | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Evidence for the role of sex in the clinical manifestations of systemic sclerosis (SSc) patients is emerging. Some multicenter cohorts have shown that male SSc patients have more severe disease and worse survival. To assess the differences in clinical manifestations and survival in Portuguese SSc patients according to gender. Data from male and female adult SSc patients included in the Rheumatic Diseases Portuguese Register (Reuma.pt) were analysed and compared. Survival was calculated for patients included in Reuma.pt. within the first two years of diagnosis (inception cohort). In total, 1054 adult patients with SSc were included, 12.5% males. No differences in demographic features and comorbidities were found between the sexes, except for a higher rate of cigarette smokers among men. Diffuse cutaneous SSc and anti-topoisomerase antibodies were more prevalent in males than females. Additionally, male patients presented significantly more myositis, interstitial lung disease and gastric involvement. There were no differences in the patterns of drug use between the sexes. During follow-up, more deaths were reported in men than women (12.1% vs 7.3%, p = 0.04). The overall 1-, 3-, and 5-year survivals from diagnosis of the inception cohort (N = 469) for men vs women were 96.4% vs 98.2%, 93% vs 95.9%, and 75.8% vs 93.2%, respectively, with statistically significant differences (p < 0.01). This study confirms the existence of gender differences in clinical and immunological SSc features. Although SSc is less common in men than women, men have a more severe expression of skin and internal organ involvement and worse survival. Key Points • There are differences in SSc disease manifestations between sexes. • Males more commonly have diffuse cutaneous SSc, anti-topoisomerase antibodies, pulmonary and musculoskeletal involvement. • In the inception cohort, men had worse survival rates than women. |
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| eu_rights_str_mv | restrictedAccess |
| format | article |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10451/52172 |
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| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
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| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/52172 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Freitas, Raquel Martins, Patrícia Martins, Patrícia http://orcid.org/0000-0003-3578-7213 0000-0003-3578-7213 Dourado, Eduardo Dourado, Eduardo https://www.ciencia-id.pt/531B-BA03-FCA0 531B-BA03-FCA0 http://orcid.org/0000-0003-2186-2833 0000-0003-2186-2833 Santiago, Tânia Guimarães, Francisca Fernandes, Bruno Miguel Garcia, Salomé Samões, Beatriz Pinto, Ana Sofia Gonçalves, Nuno Lourenco, Maria Helena Costa, Emanuel Rocha, Margarida Couto, Maura Duarte, Ana Catarina Araújo, Filipe Cordeiro, Inês Cordeiro, Inês http://orcid.org/0000-0001-9308-6728 0000-0001-9308-6728 Godinho, Fátima Resende, Catarina Salvador, Maria João Cordeiro, Ana Santos, Maria José |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Springer Nature |
| reponame_str | Repositório da Universidade de Lisboa |
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| spelling | engSpringer Naturept_PTEvidence for the role of sex in the clinical manifestations of systemic sclerosis (SSc) patients is emerging. Some multicenter cohorts have shown that male SSc patients have more severe disease and worse survival. To assess the differences in clinical manifestations and survival in Portuguese SSc patients according to gender. Data from male and female adult SSc patients included in the Rheumatic Diseases Portuguese Register (Reuma.pt) were analysed and compared. Survival was calculated for patients included in Reuma.pt. within the first two years of diagnosis (inception cohort). In total, 1054 adult patients with SSc were included, 12.5% males. No differences in demographic features and comorbidities were found between the sexes, except for a higher rate of cigarette smokers among men. Diffuse cutaneous SSc and anti-topoisomerase antibodies were more prevalent in males than females. Additionally, male patients presented significantly more myositis, interstitial lung disease and gastric involvement. There were no differences in the patterns of drug use between the sexes. During follow-up, more deaths were reported in men than women (12.1% vs 7.3%, p = 0.04). The overall 1-, 3-, and 5-year survivals from diagnosis of the inception cohort (N = 469) for men vs women were 96.4% vs 98.2%, 93% vs 95.9%, and 75.8% vs 93.2%, respectively, with statistically significant differences (p < 0.01). This study confirms the existence of gender differences in clinical and immunological SSc features. Although SSc is less common in men than women, men have a more severe expression of skin and internal organ involvement and worse survival. Key Points • There are differences in SSc disease manifestations between sexes. • Males more commonly have diffuse cutaneous SSc, anti-topoisomerase antibodies, pulmonary and musculoskeletal involvement. • In the inception cohort, men had worse survival rates than women.application/pdfpt_PTGender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohortFreitas, RaquelPersonalMartins, PatríciaDSpacehttp://dspace.org/items/28ce5691-575c-4bf4-9428-58ce9acefef7DSpacehttp://dspace.org/items/28ce5691-575c-4bf4-9428-58ce9acefef7MartinsPatríciaORCIDhttp://orcid.org0000-0003-3578-7213PersonalDourado, EduardoDSpacehttp://dspace.org/items/6ea62930-47c0-4ac2-a51c-7122f1f570a5DSpacehttp://dspace.org/items/6ea62930-47c0-4ac2-a51c-7122f1f570a5DOURADO DOMINGUESEDUARDO JORGECiência IDhttps://www.ciencia-id.pt531B-BA03-FCA0ORCIDhttp://orcid.org0000-0003-2186-2833Santiago, TâniaGuimarães, FranciscaFernandes, Bruno MiguelGarcia, SaloméSamões, BeatrizPinto, Ana SofiaGonçalves, NunoLourenco, Maria HelenaCosta, EmanuelRocha, MargaridaCouto, MauraDuarte, Ana CatarinaAraújo, FilipePersonalCordeiro, InêsDSpacehttp://dspace.org/items/e9947f3d-8ed6-4b80-b4b9-96baa387baf7DSpacehttp://dspace.org/items/e9947f3d-8ed6-4b80-b4b9-96baa387baf7CordeiroInêsORCIDhttp://orcid.org0000-0001-9308-6728Godinho, FátimaResende, CatarinaSalvador, Maria JoãoCordeiro, AnaSantos, Maria JoséHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0770-3198DOIIsPartOf10.1007/s10067-021-05997-w2022-04-05T10:45:43Z20212021-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/52172http://purl.org/coar/access_right/c_16ecrestricted accessCohortGender differencesSurvivalSystemic sclerosis779976 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/c2e539c9-6f48-4b58-88c5-b9b8f14ae1d1/downloadClinical Rheumatology41411391144 |
| spellingShingle | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort Freitas, Raquel Cohort Gender differences Survival Systemic sclerosis Freitas, Raquel Cohort Gender differences Survival Systemic sclerosis |
| status | SINGLETON |
| subject.fl_str_mv | Cohort Gender differences Survival Systemic sclerosis |
| title | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort |
| title_full | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort |
| title_fullStr | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort |
| title_full_unstemmed | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort |
| title_short | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort |
| title_sort | Gender differences in clinical features and outcomes of a Portuguese systemic sclerosis cohort |
| topic | Cohort Gender differences Survival Systemic sclerosis |
| topic_facet | Cohort Gender differences Survival Systemic sclerosis |
| url | http://hdl.handle.net/10451/52172 |
| visible | 1 |