Publicação
Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines
| Resumo: | Objective: There is a well known association between mitral valve prolapse (MVP) and low blood pressure (BP), although patients often have high levels of catecholamines and high heart rate (HR). The main objective of our study was to evaluate the effects of long-term adrenergic beta-blockade on these parameters. Methods: The study population consisted of 46 patients with MVP and the control group consisted of 20 normal individuals. The study had two phases: in the first phase, patients were free of medications. In the second phase, patients were under treatment with propranolol for 10 to 12 months. The tests were performed in normal individuals and patients in the first phase. Only patients underwent the same tests in the second phase. Measurement of urinary epinephrine and norepinephrine levels, by high performance liquid chromatography, was done. Rest HR was determined by electrocardiogram (ECG), and ambulatory blood pressure and HR were evaluated by 24 hours ambulatory blood pressure monitoring (ABPM) using the auscultatory method. Results: The levels of epinephrine and norepinephrine were significantly higher in patients than in normal controls and decreased under propranolol. Rest and ambulatory HR were higher in patients and decreased under propranolol. The 24 hours systolic and diastolic BPs were lower in patients, and their values increased under propranolol. Heart rate decreasing and epinephrine levels reduction were positively correlated. No correlation was found between BP increase and catecholamine levels. Conclusion: The study results show divergent effects of propranolol on blood pressure, which increased, and on heart rate, that decreased, in patients with MVP. Heart rate decrease was an expected result and depends, namely, on b1 receptors blockade. Increase in BP is an unusual response to adrenergic beta-blockade in normal conditions, and this finding supports the preponderance of b2 receptors on the BP control in patients with MVP. |
|---|---|
| Autores principais: | da Silva, Emilia Pereira |
| Outros Autores: | Mendes Pedro, Mónica; Varela, Manuel Gato; Cortez-Dias, Nuno; Bicho, Manuel; Madeira, Hugo; Lopes, Mario G. |
| Assunto: | Mitral valve prolapse Blood pressure Heart rate Beta-blockade |
| Ano: | 2007 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866809662035197952 |
|---|---|
| author | da Silva, Emilia Pereira |
| author2 | Mendes Pedro, Mónica Varela, Manuel Gato Cortez-Dias, Nuno Bicho, Manuel Madeira, Hugo Lopes, Mario G. |
| author2_role | author author author author author author |
| author_facet | da Silva, Emilia Pereira Mendes Pedro, Mónica Varela, Manuel Gato Cortez-Dias, Nuno Bicho, Manuel Madeira, Hugo Lopes, Mario G. |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"da Silva, Emilia Pereira\"},{\"Person.name\":\"Mendes Pedro, Mónica\",\"Person.identifier.orcid\":\"0000-0002-2782-4398\"},{\"Person.name\":\"Varela, Manuel Gato\"},{\"Person.name\":\"Cortez-Dias, Nuno\",\"Person.identifier.orcid\":\"0000-0002-9244-4631\"},{\"Person.name\":\"Bicho, Manuel\",\"Person.identifier.orcid\":\"0000-0002-5773-5687\"},{\"Person.name\":\"Madeira, Hugo\",\"Person.identifier.orcid\":\"0000-0003-4291-2289\"},{\"Person.name\":\"Lopes, Mario G.\",\"Person.identifier.orcid\":\"0000-0002-2855-5118\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | da Silva, Emilia Pereira Mendes Pedro, Mónica Varela, Manuel Gato Cortez-Dias, Nuno Bicho, Manuel Madeira, Hugo Lopes, Mario G. |
| datacite.date.Accepted.fl_str_mv | 2007-07-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-05-14T15:36:25Z |
| datacite.date.embargoed.fl_str_mv | 2021-05-14T15:36:25Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Mitral valve prolapse Blood pressure Heart rate Beta-blockade |
| datacite.titles.title.fl_str_mv | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | da Silva, Emilia Pereira Mendes Pedro, Mónica Varela, Manuel Gato Cortez-Dias, Nuno Bicho, Manuel Madeira, Hugo Lopes, Mario G. |
| dc.date.Accepted.fl_str_mv | 2007-07-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-05-14T15:36:25Z |
| dc.date.embargoed.fl_str_mv | 2021-05-14T15:36:25Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/47899 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | AVES Yayıncılık |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Mitral valve prolapse Blood pressure Heart rate Beta-blockade |
| dc.title.fl_str_mv | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Objective: There is a well known association between mitral valve prolapse (MVP) and low blood pressure (BP), although patients often have high levels of catecholamines and high heart rate (HR). The main objective of our study was to evaluate the effects of long-term adrenergic beta-blockade on these parameters. Methods: The study population consisted of 46 patients with MVP and the control group consisted of 20 normal individuals. The study had two phases: in the first phase, patients were free of medications. In the second phase, patients were under treatment with propranolol for 10 to 12 months. The tests were performed in normal individuals and patients in the first phase. Only patients underwent the same tests in the second phase. Measurement of urinary epinephrine and norepinephrine levels, by high performance liquid chromatography, was done. Rest HR was determined by electrocardiogram (ECG), and ambulatory blood pressure and HR were evaluated by 24 hours ambulatory blood pressure monitoring (ABPM) using the auscultatory method. Results: The levels of epinephrine and norepinephrine were significantly higher in patients than in normal controls and decreased under propranolol. Rest and ambulatory HR were higher in patients and decreased under propranolol. The 24 hours systolic and diastolic BPs were lower in patients, and their values increased under propranolol. Heart rate decreasing and epinephrine levels reduction were positively correlated. No correlation was found between BP increase and catecholamine levels. Conclusion: The study results show divergent effects of propranolol on blood pressure, which increased, and on heart rate, that decreased, in patients with MVP. Heart rate decrease was an expected result and depends, namely, on b1 receptors blockade. Increase in BP is an unusual response to adrenergic beta-blockade in normal conditions, and this finding supports the preponderance of b2 receptors on the BP control in patients with MVP. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/9cc44c47-723c-4377-b0d5-b23b91ac5113/download |
| id | ul_e872fd87f03f322a816d42e4e965eddf |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/47899 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/47899 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | da Silva, Emilia Pereira Mendes Pedro, Mónica Mendes Pedro, Mónica https://www.ciencia-id.pt/581D-B84F-DE80 581D-B84F-DE80 http://orcid.org/0000-0002-2782-4398 0000-0002-2782-4398 Varela, Manuel Gato Cortez-Dias, Nuno Cortez-Dias, Nuno https://www.ciencia-id.pt/D612-D3C3-6E1D D612-D3C3-6E1D http://orcid.org/0000-0002-9244-4631 0000-0002-9244-4631 Bicho, Manuel Bicho, Manuel https://www.ciencia-id.pt/9512-8D22-1B28 9512-8D22-1B28 http://orcid.org/0000-0002-5773-5687 0000-0002-5773-5687 Madeira, Hugo Madeira, Hugo https://www.ciencia-id.pt/AC1C-BBD0-2EDF AC1C-BBD0-2EDF http://orcid.org/0000-0003-4291-2289 0000-0003-4291-2289 Lopes, Mario G. Lopes, Mario G. http://orcid.org/0000-0002-2855-5118 0000-0002-2855-5118 |
| publishDate | 2007 |
| publisher.none.fl_str_mv | AVES Yayıncılık |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engAVES Yayıncılıkpt_PTObjective: There is a well known association between mitral valve prolapse (MVP) and low blood pressure (BP), although patients often have high levels of catecholamines and high heart rate (HR). The main objective of our study was to evaluate the effects of long-term adrenergic beta-blockade on these parameters. Methods: The study population consisted of 46 patients with MVP and the control group consisted of 20 normal individuals. The study had two phases: in the first phase, patients were free of medications. In the second phase, patients were under treatment with propranolol for 10 to 12 months. The tests were performed in normal individuals and patients in the first phase. Only patients underwent the same tests in the second phase. Measurement of urinary epinephrine and norepinephrine levels, by high performance liquid chromatography, was done. Rest HR was determined by electrocardiogram (ECG), and ambulatory blood pressure and HR were evaluated by 24 hours ambulatory blood pressure monitoring (ABPM) using the auscultatory method. Results: The levels of epinephrine and norepinephrine were significantly higher in patients than in normal controls and decreased under propranolol. Rest and ambulatory HR were higher in patients and decreased under propranolol. The 24 hours systolic and diastolic BPs were lower in patients, and their values increased under propranolol. Heart rate decreasing and epinephrine levels reduction were positively correlated. No correlation was found between BP increase and catecholamine levels. Conclusion: The study results show divergent effects of propranolol on blood pressure, which increased, and on heart rate, that decreased, in patients with MVP. Heart rate decrease was an expected result and depends, namely, on b1 receptors blockade. Increase in BP is an unusual response to adrenergic beta-blockade in normal conditions, and this finding supports the preponderance of b2 receptors on the BP control in patients with MVP.application/pdfpt_PTHeart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholaminesda Silva, Emilia PereiraPersonalMendes Pedro, MónicaDSpacehttp://dspace.org/items/6b00637f-d663-4f64-8416-bc022a1e1b7fDSpacehttp://dspace.org/items/6b00637f-d663-4f64-8416-bc022a1e1b7fMendes PedroMónicaCiência IDhttps://www.ciencia-id.pt581D-B84F-DE80ORCIDhttp://orcid.org0000-0002-2782-4398Varela, Manuel GatoPersonalCortez-Dias, NunoDSpacehttp://dspace.org/items/36f4a32d-38e4-4c28-9140-4ba468059a22DSpacehttp://dspace.org/items/36f4a32d-38e4-4c28-9140-4ba468059a22Cortez-DiasNunoCiência IDhttps://www.ciencia-id.ptD612-D3C3-6E1DORCIDhttp://orcid.org0000-0002-9244-4631PersonalBicho, ManuelDSpacehttp://dspace.org/items/c61e4f7e-28b3-47b4-bc5d-677b73fc3aecDSpacehttp://dspace.org/items/c61e4f7e-28b3-47b4-bc5d-677b73fc3aecBichoManuelCiência IDhttps://www.ciencia-id.pt9512-8D22-1B28ORCIDhttp://orcid.org0000-0002-5773-5687Scopus Author IDhttps://www.scopus.com7004153755PersonalMadeira, HugoDSpacehttp://dspace.org/items/e108d0e0-df11-4a5e-92e5-40f0138d1249DSpacehttp://dspace.org/items/e108d0e0-df11-4a5e-92e5-40f0138d1249MadeiraHugoCiência IDhttps://www.ciencia-id.ptAC1C-BBD0-2EDFORCIDhttp://orcid.org0000-0003-4291-2289Scopus Author IDhttps://www.scopus.com7004929005PersonalLopes, Mario G.DSpacehttp://dspace.org/items/e10fab1d-b38c-4b29-aed8-68998f1c6d61DSpacehttp://dspace.org/items/e10fab1d-b38c-4b29-aed8-68998f1c6d61LopesMario G.ORCIDhttp://orcid.org0000-0002-2855-5118Scopus Author IDhttps://www.scopus.com7202369014HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf2149-22632021-05-14T15:36:25Z2007-072007-07-01T00:00:00ZHandlehttp://hdl.handle.net/10451/47899http://purl.org/coar/access_right/c_abf2open accessMitral valve prolapseBlood pressureHeart rateBeta-blockade72928 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2007-07http://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/9cc44c47-723c-4377-b0d5-b23b91ac5113/downloadThe Anatolian Journal of Cardiology7Suppl 1107109 |
| spellingShingle | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines da Silva, Emilia Pereira Mitral valve prolapse Blood pressure Heart rate Beta-blockade |
| status | SINGLETON |
| subject.fl_str_mv | Mitral valve prolapse Blood pressure Heart rate Beta-blockade |
| title | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines |
| title_full | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines |
| title_fullStr | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines |
| title_full_unstemmed | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines |
| title_short | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines |
| title_sort | Heart rate and blood pressure in mitral valve prolapse patients : divergent effects of long-term propranolol therapy and correlations with catecholamines |
| topic | Mitral valve prolapse Blood pressure Heart rate Beta-blockade |
| topic_facet | Mitral valve prolapse Blood pressure Heart rate Beta-blockade |
| url | http://hdl.handle.net/10451/47899 |
| visible | 1 |