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Three new jatrophane polyesters and anti proliferative constituents from Euphorbia tuckeyana

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Resumo:Three new jatrophane diterpene polyesters named tuckeyanols A and B and euphotuckeyanol, as well as ten known compounds, helioscopinolides A, 13, D and E, naringenin, aromadendrin, coniferaldehyde, 4,20-dideoxy-5-hydroxyphorbol 12,13-diisobutyrate, 4,20-dideoxy-5-hydroxyphorbol 12-benzoate-13-isobutyrate and dehydrodiconiferyl diacetate, were isolated from the methanolic extract of Euphorbia tuckeyana. Their structures were elucidated by physical and spectroscopic methods including 1 D and 2 D homo- and heteronuclear NMR techniques (COSY, HMQC, HMBC and NOESY), and HR-mass spectrometry. Four of the isolated compounds were investigated for their anti proliferative activity in three human gastrointestinal cancer cell lines: gastric (EPG85-257), pancreatic (EPP85-181) and colon (HT-29) carcinomas. Three of them have showed to be moderate inhibitors of the growth of gastric and pancreatic tumor cell lines.
Autores principais:Duarte, Noelia
Outros Autores:Lage, Hermann; Ferreira, Maria-Jose U.
Assunto:Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy
Ano:2008
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso a metadados
Instituição associada:Universidade de Lisboa
Idioma:inglês
Origem:Repositório da Universidade de Lisboa

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