Publicação
The influence of DNA methylation on monoallelic expression
| Resumo: | Monoallelic gene expression occurs in diploid cells when only one of the two alleles of a gene is active. There are three main classes of genes that display monoallelic expression in mammalian genomes: (1) imprinted genes that are monoallelically expressed in a parent-of-origin dependent manner; (2) X-linked genes that undergo random X-chromosome inactivation in female cells; (3) random monoallelically expressed single and clustered genes located on autosomes. The heritability of monoallelic expression patterns during cell divisions implies that epigenetic mechanisms are involved in the cellular memory of these expression states. Among these, methylation of CpG sites on DNA is one of the best described modification to explain somatic inheritance. Here, we discuss the relevance of DNA methylation for the establishment and maintenance of monoallelic expression patterns among these three groups of genes, and how this is intrinsically linked to development and cellular states. |
|---|---|
| Autores principais: | da Rocha, Simão T. |
| Outros Autores: | Gendrel, Anne-Valerie |
| Assunto: | DNA methylation X-chromosome inactivation Epigenetics Imprinting Monoallelic expression |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1866810301871030272 |
|---|---|
| author | da Rocha, Simão T. |
| author2 | Gendrel, Anne-Valerie |
| author2_role | author |
| author_facet | da Rocha, Simão T. Gendrel, Anne-Valerie |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"da Rocha, Simão T.\",\"Person.identifier.orcid\":\"0000-0002-9683-7942\"},{\"Person.name\":\"Gendrel, Anne-Valerie\",\"Person.identifier.orcid\":\"0000-0003-4510-0024\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | da Rocha, Simão T. Gendrel, Anne-Valerie |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-12-10T14:10:00Z |
| datacite.date.embargoed.fl_str_mv | 2021-12-10T14:10:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | DNA methylation X-chromosome inactivation Epigenetics Imprinting Monoallelic expression |
| datacite.titles.title.fl_str_mv | The influence of DNA methylation on monoallelic expression |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | da Rocha, Simão T. Gendrel, Anne-Valerie |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-12-10T14:10:00Z |
| dc.date.embargoed.fl_str_mv | 2021-12-10T14:10:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/50331 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Portland Press |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | DNA methylation X-chromosome inactivation Epigenetics Imprinting Monoallelic expression |
| dc.title.fl_str_mv | The influence of DNA methylation on monoallelic expression |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Monoallelic gene expression occurs in diploid cells when only one of the two alleles of a gene is active. There are three main classes of genes that display monoallelic expression in mammalian genomes: (1) imprinted genes that are monoallelically expressed in a parent-of-origin dependent manner; (2) X-linked genes that undergo random X-chromosome inactivation in female cells; (3) random monoallelically expressed single and clustered genes located on autosomes. The heritability of monoallelic expression patterns during cell divisions implies that epigenetic mechanisms are involved in the cellular memory of these expression states. Among these, methylation of CpG sites on DNA is one of the best described modification to explain somatic inheritance. Here, we discuss the relevance of DNA methylation for the establishment and maintenance of monoallelic expression patterns among these three groups of genes, and how this is intrinsically linked to development and cellular states. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/615c0d56-6357-4370-982e-da5bd87c62c0/download |
| funding.funder.alternateName_str_mv | FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| funding.name_str_mv | 6817 - DCRRNI ID |
| id | ul_f836c055b79e2eec8a2bf2ea091e19f6 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/50331 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/50331 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | da Rocha, Simão T. da Rocha, Simão T. https://www.ciencia-id.pt/1310-8F0F-1387 1310-8F0F-1387 http://orcid.org/0000-0002-9683-7942 0000-0002-9683-7942 Gendrel, Anne-Valerie Gendrel, Anne-Valerie https://www.ciencia-id.pt/1917-59ED-F318 1917-59ED-F318 http://orcid.org/0000-0003-4510-0024 0000-0003-4510-0024 |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Portland Press |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engPortland Presspt_PTMonoallelic gene expression occurs in diploid cells when only one of the two alleles of a gene is active. There are three main classes of genes that display monoallelic expression in mammalian genomes: (1) imprinted genes that are monoallelically expressed in a parent-of-origin dependent manner; (2) X-linked genes that undergo random X-chromosome inactivation in female cells; (3) random monoallelically expressed single and clustered genes located on autosomes. The heritability of monoallelic expression patterns during cell divisions implies that epigenetic mechanisms are involved in the cellular memory of these expression states. Among these, methylation of CpG sites on DNA is one of the best described modification to explain somatic inheritance. Here, we discuss the relevance of DNA methylation for the establishment and maintenance of monoallelic expression patterns among these three groups of genes, and how this is intrinsically linked to development and cellular states.application/pdfpt_PTThe influence of DNA methylation on monoallelic expressionPersonalda Rocha, Simão T.DSpacehttp://dspace.org/items/52b38b81-1fbe-42e0-9c6b-a334400ae3d6DSpacehttp://dspace.org/items/52b38b81-1fbe-42e0-9c6b-a334400ae3d6Teixeira da RochaSimão JoséCiência IDhttps://www.ciencia-id.pt1310-8F0F-1387ORCIDhttp://orcid.org0000-0002-9683-7942PersonalGendrel, Anne-ValerieDSpacehttp://dspace.org/items/f537507b-f2dc-45d9-a5c9-78b2180f549bDSpacehttp://dspace.org/items/f537507b-f2dc-45d9-a5c9-78b2180f549bGendrelAnne-ValerieCiência IDhttps://www.ciencia-id.pt1917-59ED-F318ORCIDhttp://orcid.org0000-0003-4510-0024Researcher IDhttps://www.researcherid.comE-5584-2017HostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0071-1365DOIIsPartOf10.1042/EBC201900342021-12-10T14:10:00Z20192019-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/50331http://purl.org/coar/access_right/c_abf2open accessDNA methylationX-chromosome inactivationEpigeneticsImprintingMonoallelic expression1194831 bytesFundação para a Ciência e a TecnologiaInstituto de Medicina Molecular6817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2019http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/615c0d56-6357-4370-982e-da5bd87c62c0/downloadEssays in Biochemistry636663676 |
| spellingShingle | The influence of DNA methylation on monoallelic expression da Rocha, Simão T. DNA methylation X-chromosome inactivation Epigenetics Imprinting Monoallelic expression |
| status | SINGLETON |
| subject.fl_str_mv | DNA methylation X-chromosome inactivation Epigenetics Imprinting Monoallelic expression |
| title | The influence of DNA methylation on monoallelic expression |
| title_full | The influence of DNA methylation on monoallelic expression |
| title_fullStr | The influence of DNA methylation on monoallelic expression |
| title_full_unstemmed | The influence of DNA methylation on monoallelic expression |
| title_short | The influence of DNA methylation on monoallelic expression |
| title_sort | The influence of DNA methylation on monoallelic expression |
| topic | DNA methylation X-chromosome inactivation Epigenetics Imprinting Monoallelic expression |
| topic_facet | DNA methylation X-chromosome inactivation Epigenetics Imprinting Monoallelic expression |
| url | http://hdl.handle.net/10451/50331 |
| visible | 1 |