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Insuficiência hepática aguda provocada por Amanita phalloides

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Resumo:There are certain mushroom species that are able to induce acute liver failure. Amanita phalloides is responsible for most poisonings. This paper analyses the pathogenesis, clinical features, therapeutic strategies and selection criteria for transplantation in the acute liver failure associated to ingestion of Amanita phalloides. The toxins of Amanita phalloides are capable of inhibiting RNA polymerase II resulting in a deficient protein synthesis and cell necrosis. The most affected organ is the liver, however, the kidney is also involved. After an asymptomatic phase, the clinical picture is characterised by gastrointestinal symptoms, followed by liver and kidney involvement and toxicity may progress to death if correct treatment isn´t established. The treatment consists of supportive measures, detoxification, hepatoprotective therapies and, in the most severe cases, transplantation can be indicated.
Autores principais:Lourenço, Ana Luísa Martins
Assunto:Insuficiência hepática Amanita phalloides Terapêutica
Ano:2014
País:Portugal
Tipo de documento:dissertação de mestrado
Tipo de acesso:acesso restrito
Instituição associada:Universidade de Lisboa
Idioma:português
Origem:Repositório da Universidade de Lisboa

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