Publicação
Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey
| Resumo: | Background: Despite the high effectiveness of the Haemophilus influenzae type b (Hib) vaccine in preventing invasive disease (ID) in children, Hib vaccine failures (VFs) cases may still occur. This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. Methods: Prospective descriptive nationwide surveillance study. Bacteriologic and molecular studies were performed at the same Reference Laboratory. Clinical data were collected by the referring pediatrician. Results: Hib was identified in 41 children with ID and 26 (63%) were considered VF. Nineteen (73%) cases occurred in children less than 5 years old; 12 (46%) occurred before the Hib vaccine booster dose at 18 months of age. Comparing the first and the last 6-year periods of the study, the incidence rate of Hib, VF and total H. influenzae (Hi) ID significantly raised ( P < 0.05). VF cases corresponded, respectively, to 13.5% (7/52) and 22% (19/88) of total Hi-ID cases ( P = 0.232). Two children died due to epiglottitis and 1 acquired sensorineural hearing loss. Only 1 child had an inborn error of immunity. The immunologic workup performed in 9 children revealed no significant abnormalities. All 25 Hib-VF strains analyzed belonged to the same clonal complex 6. Conclusions: In Portugal, more than 95% of children are vaccinated against Hib, but severe Hib-ID cases still occur. No predisposing factors were clearly identified to justify the increased number of VF in recent years. Along with continued Hi-ID surveillance, Hib colonization and serologic studies should be implemented. |
|---|---|
| Autores principais: | Marques, José |
| Outros Autores: | Inácio Cunha, Florbela Maria; Bajanca-Lavado, Maria Paula |
| Assunto: | Haemophilus influenzae Vaccine Failure |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório da Universidade de Lisboa |
| _version_ | 1865920854006693888 |
|---|---|
| author | Marques, José |
| author2 | Inácio Cunha, Florbela Maria Bajanca-Lavado, Maria Paula |
| author2_role | author author |
| author_facet | Marques, José Marques, José Inácio Cunha, Florbela Maria Bajanca-Lavado, Maria Paula Inácio Cunha, Florbela Maria Bajanca-Lavado, Maria Paula |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Marques, José\",\"Person.identifier.orcid\":\"0000-0001-7982-6697\"},{\"Person.name\":\"Inácio Cunha, Florbela Maria\"},{\"Person.name\":\"Bajanca-Lavado, Maria Paula\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Marques, José Inácio Cunha, Florbela Maria Bajanca-Lavado, Maria Paula |
| datacite.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-09-12T13:00:03Z |
| datacite.date.embargoed.fl_str_mv | 2023-09-12T13:00:03Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Haemophilus influenzae Vaccine Failure |
| datacite.titles.title.fl_str_mv | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Marques, José Inácio Cunha, Florbela Maria Bajanca-Lavado, Maria Paula |
| dc.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-09-12T13:00:03Z |
| dc.date.embargoed.fl_str_mv | 2023-09-12T13:00:03Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/59229 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | LWW Journals |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Haemophilus influenzae Vaccine Failure |
| dc.title.fl_str_mv | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: Despite the high effectiveness of the Haemophilus influenzae type b (Hib) vaccine in preventing invasive disease (ID) in children, Hib vaccine failures (VFs) cases may still occur. This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. Methods: Prospective descriptive nationwide surveillance study. Bacteriologic and molecular studies were performed at the same Reference Laboratory. Clinical data were collected by the referring pediatrician. Results: Hib was identified in 41 children with ID and 26 (63%) were considered VF. Nineteen (73%) cases occurred in children less than 5 years old; 12 (46%) occurred before the Hib vaccine booster dose at 18 months of age. Comparing the first and the last 6-year periods of the study, the incidence rate of Hib, VF and total H. influenzae (Hi) ID significantly raised ( P < 0.05). VF cases corresponded, respectively, to 13.5% (7/52) and 22% (19/88) of total Hi-ID cases ( P = 0.232). Two children died due to epiglottitis and 1 acquired sensorineural hearing loss. Only 1 child had an inborn error of immunity. The immunologic workup performed in 9 children revealed no significant abnormalities. All 25 Hib-VF strains analyzed belonged to the same clonal complex 6. Conclusions: In Portugal, more than 95% of children are vaccinated against Hib, but severe Hib-ID cases still occur. No predisposing factors were clearly identified to justify the increased number of VF in recent years. Along with continued Hi-ID surveillance, Hib colonization and serologic studies should be implemented. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/a04e0712-71f7-4fa5-88ed-1c64fe567cb6/download |
| id | ul_ff2635c089e8a8e366d5f6d4f2ddd7a1 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/59229 |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/59229 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Marques, José Marques, José https://www.ciencia-id.pt/3F14-1AE6-0F43 3F14-1AE6-0F43 http://orcid.org/0000-0001-7982-6697 0000-0001-7982-6697 Inácio Cunha, Florbela Maria Bajanca-Lavado, Maria Paula |
| publishDate | 2023 |
| publisher.none.fl_str_mv | LWW Journals |
| reponame_str | Repositório da Universidade de Lisboa |
| repository_id_str | urn:repositoryAcronym:ul |
| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engLWW Journalspt_PTBackground: Despite the high effectiveness of the Haemophilus influenzae type b (Hib) vaccine in preventing invasive disease (ID) in children, Hib vaccine failures (VFs) cases may still occur. This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. Methods: Prospective descriptive nationwide surveillance study. Bacteriologic and molecular studies were performed at the same Reference Laboratory. Clinical data were collected by the referring pediatrician. Results: Hib was identified in 41 children with ID and 26 (63%) were considered VF. Nineteen (73%) cases occurred in children less than 5 years old; 12 (46%) occurred before the Hib vaccine booster dose at 18 months of age. Comparing the first and the last 6-year periods of the study, the incidence rate of Hib, VF and total H. influenzae (Hi) ID significantly raised ( P < 0.05). VF cases corresponded, respectively, to 13.5% (7/52) and 22% (19/88) of total Hi-ID cases ( P = 0.232). Two children died due to epiglottitis and 1 acquired sensorineural hearing loss. Only 1 child had an inborn error of immunity. The immunologic workup performed in 9 children revealed no significant abnormalities. All 25 Hib-VF strains analyzed belonged to the same clonal complex 6. Conclusions: In Portugal, more than 95% of children are vaccinated against Hib, but severe Hib-ID cases still occur. No predisposing factors were clearly identified to justify the increased number of VF in recent years. Along with continued Hi-ID surveillance, Hib colonization and serologic studies should be implemented.application/pdfpt_PTHaemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric surveyPersonalMarques, JoséDSpacehttp://dspace.org/items/aedb12d3-3390-4f2a-b61f-5b83a921392cDSpacehttp://dspace.org/items/aedb12d3-3390-4f2a-b61f-5b83a921392cMARQUESJOSÉCiência IDhttps://www.ciencia-id.pt3F14-1AE6-0F43ORCIDhttp://orcid.org0000-0001-7982-6697Inácio Cunha, Florbela MariaBajanca-Lavado, Maria PaulaHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@reitoria.ulisboa.ptrepositorio@reitoria.ulisboa.ptISSNIsPartOf0891-3668DOIIsPartOf10.1097/INF.00000000000040112023-09-12T13:00:03Z20232023-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/59229http://purl.org/coar/access_right/c_16ecrestricted accessHaemophilus influenzaeVaccineFailure488824 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/a04e0712-71f7-4fa5-88ed-1c64fe567cb6/downloadPediatric Infectious Disease Journal429824828 |
| spellingShingle | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey Marques, José Haemophilus influenzae Vaccine Failure Marques, José Haemophilus influenzae Vaccine Failure |
| status | SINGLETON |
| subject.fl_str_mv | Haemophilus influenzae Vaccine Failure |
| title | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey |
| title_full | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey |
| title_fullStr | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey |
| title_full_unstemmed | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey |
| title_short | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey |
| title_sort | Haemophilus influenzae type b vaccine failure in Portugal: a nationwide multicenter pediatric survey |
| topic | Haemophilus influenzae Vaccine Failure |
| topic_facet | Haemophilus influenzae Vaccine Failure |
| url | http://hdl.handle.net/10451/59229 |
| visible | 1 |