Publicação
Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression.
| Resumo: | Background: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous Ecadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed.However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001).Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression.The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression |
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| Autores principais: | Silva, Filipe |
| Outros Autores: | Lopes, Carlos Alberto da Silva; Alves, Anabela; Queiroga, Felisbina; Pires, Isabel |
| Assunto: | Canine cutaneous histiocytoma E-cadherin immunohistochemistry tumour regression |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Trás-os-Montes e Alto Douro |
| Idioma: | inglês |
| Origem: | Repositório da UTAD |
| Resumo: | Background: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous Ecadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed.However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001).Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression.The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression |
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