Publicação

Decrease of E-cadherin expression in canine cutaneous histiocytoma appears to be related to its spontaneous regression.

Ver documento

Detalhes bibliográficos
Resumo:Background: Canine cutaneous histiocytoma (CCH) is an epidermotropic tumour of Langerhans cells, most frequent in young dogs, which undergoes spontaneous regression. Materials and Methods: E-cadherin immunoexpression was analysed in ninety-three CCH, categorized according to Cockerell and Slauson (1976) criteria into four histological groups, representing different stages of tumour regression. Results: All tumours expressed membranous Ecadherin both in keratinocytes, and in tumoural cells and no differences were noted among the histological groups analysed.However, the intensity of the E-cadherin immunolabeling decreased in the presence of lymphoid infiltration and varied significantly among the groups considered (p<0.0001).Conclusion: This study strongly suggests a down-regulation of E-cadherin expression in CCH pathogenesis and progression.The loss of E-cadherin expression might represent an activation/ maturation process of the tumoural cells constituting a switch for CCH regression
Autores principais:Silva, Filipe
Outros Autores:Lopes, Carlos Alberto da Silva; Alves, Anabela; Queiroga, Felisbina; Pires, Isabel
Assunto:Canine cutaneous histiocytoma E-cadherin immunohistochemistry tumour regression
Ano:2009
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade de Trás-os-Montes e Alto Douro
Idioma:inglês
Origem:Repositório da UTAD

Registos relacionados

Registos relacionados