Author(s): Duarte, Nádia ; Coelho, Inês C. ; Patarrão, Rita S. ; Almeida, Joana I. ; Penha-Gonçalves, Carlos ; Macedo, M. Paula
Date: 2015
Persistent ID: http://hdl.handle.net/10400.7/554
Origin: ARCA - Access to Research and Communication Annals
Subject(s): Inflammation; Kupffer Cells
Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most prevalent cause of liver disease worldwide and afflicts adults and children as currently associated with obesity and insulin resistance. Even though lately some advances have been made to elucidate the mechanism and causes of the disease much remains unknown about NAFLD. The aim of this paper is to discuss the present knowledge regarding the pathogenesis of the disease aiming at the initial steps of NAFLD development, when inflammation impinges on fat liver deposition. At this stage, the Kupffer cells attain a prominent role. This knowledge becomes subsequently relevant for the development of future diagnostic, prevention, and therapeutic options for the management of NAFLD.
