Autor(es):
Filipe, Márcia Santos ; Domínguez-Martín, Eva M. ; Pires, Tânia C.S.P. ; Finimundy, Tiane C. ; Melgar Castañeda, Bruno ; Mandim, Filipa ; Isca, Vera M. S. ; Pereira, Raquel ; Teixidó-Trujillo, Silvia ; Capote, Natalia A. ; Nikolić, Milan ; Filipović, Nenad ; Díaz-Lanza, Ana M. ; Figueiredo, Ana Cristina ; Barros, Lillian ; Rijo, Patrícia
Data: 2024
Identificador Persistente: http://hdl.handle.net/10198/29706
Origem: Biblioteca Digital do IPB
Projeto/bolsa:
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04567%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04567%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0094%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0007%2F2020/PT;
info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F146614%2F2019/PT;
Assunto(s): Plectranthus; Essential oil
Descrição
The Plectranthus genus (Lamiaceae) is known to be rich in abietane diterpenes. The bioactive 6,7-dehydroxyroyleanone (DHR, 1) was previously isolated from Plectranthus madagascariensis var. madagascariensis and var. aliciae. This study aimed to explore the occurrence of DHR, 1, in P. aliciae and the potential bioactivities of new semisynthetic derivatives from DHR, 1. Several extraction methods were evaluated, and the hydrodistillation, using a Clevenger apparatus, afforded the highest yield (77.8 mg/g of 1 in the essential oil). Three new acyl derivatives (2-4) were successfully prepared from 1 (yields of 86-95%). Compounds 1-4 showed antioxidant activity, antibacterial effects, potent cytotoxic activity against several cell lines, and enhanced anti-inflammatory activity that surpassed dexamethasone (positive control). These findings encourage further exploration of derivatives 2-4 for potential mechanisms of antitumoral, antioxidant, and anti-inflammatory capabilities, studying both safety and efficacy.
This work was supported by the funding received by Fundação paraaCien̂ciaeTecnologia(FCT,Portugal)(projects DOI 10.54499/UIDP/04567/2020 and DOI 10.54499/UIDB/04567/2020 attributed to CBIOS, CIMO (UIDB/00690/2020 and UIDP/00690/2020), CESAM (UIDP/50017/2020, UIDB/50017/2020, LA/P/0094/2020), and SusTEC (LA/P/0007/2020) and a Ph.D. grant for F.M. (SFRH/BD/ 146614/2019). National funding was provided by FCT, P.I., through the institutional scientific employment program contracts (L.B.). E.M.D.-M. gratefully acknowledges being the recipient of a FPU-UAH 2019 contract and for the grant “Ayudas a la Movilidad del Personal Investigador en Formación 2022” from the University of Alcalá de Henares (UAH). The authors thank the laboratory CIMO-ESTIG for permission to use the balance ABT-100 ESM Kern (Balingen, Germany) and Escola Superior Agrária laboratory for the use of the mill IKA-WERKE M20.
