Author(s):
Khan, Haroon ; Ullah, Hammad ; Castilho, Paula Cristina Machado Ferreira ; Gomila, Antoni Sureda ; D'Onofrio, Grazia ; Filosa, Rosanna ; Wang, Fang ; Nabavi, Seyed Mohammad ; Daglia, Maria ; Silva, Ana Sanches ; Rengasamy, Kannan R. R. ; Ou, Juanying ; Zou, Xiaobo ; Xiao, Jianbo ; Cao, Hui
Date: 2019
Persistent ID: http://hdl.handle.net/10400.13/3198
Origin: DigitUMa - Repositório da Universidade da Madeira
Subject(s): Dietary polyphenols; Cancer; Signaling pathway; Nuclear factor-jB; Phosphorylation; .; Faculdade de Ciências Exatas e da Engenharia; Centro de Química da Madeira
Description
Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB could act as a tumor activator or tumor suppressant decided by the site of action (organ). Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-κB signaling pathway. They depress the phosphorylation of kinases, inhibit NF-κB translocate into the nucleus as well as interfere interactions between NF-κB and DNA. Through inhibition of NF-κB, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. This review highlights the anticancer effects of polyphenols on the basis of NF-κB signaling pathway regulation.
